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The genetic study of computer game addiction

Published online by Cambridge University Press:  23 March 2020

D. Mavani ,
V. Soldatkin ,
E. Mashkina ,
A. Dyachenko ,
E. Karpova  and
O. Bukhanovskaya
D. Mavani
Affiliation:
Scientific Center for Treatment and Rehabilitation “Phoenix”, Psychiatry department, Rostov-on-Don, Russia
V. Soldatkin
Affiliation:
Rostov State Medical University, Psychiatry department, Rostov-on-Don, Russia
E. Mashkina
Affiliation:
South Federal University, Genetics department, Rostov-on-Don, Russia
A. Dyachenko
Affiliation:
Scientific Center for Treatment and Rehabilitation “Phoenix”, Psychiatry department, Rostov-on-Don, Russia
E. Karpova
Affiliation:
Scientific Center for Treatment and Rehabilitation “Phoenix”, Psychiatry department, Rostov-on-Don, Russia
O. Bukhanovskaya
Affiliation:
Scientific Center for Treatment and Rehabilitation “Phoenix”, Psychiatry department, Rostov-on-Don, Russia

Abstract

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Introduction

Addiction to computer games (CA) is growing with a lightning speed in whole world. Very few studies are focused in the genetic basis of this disorder.

Objectives

To study the COMT and MAOA polymorphism in addicts to computer games.

Methods

Totally 42 persons were included in this study, 22 of them had CA and 20 were totally healthy. Out of 22 gamers, 10 persons had only CA. The rest of 12 patients suffered from another psychiatric disorder besides of CA (Schizotypal disorder, depression, bipolar disorder). Their mean age was 16 years (15; 17) and all of them were males.

Results

The total frequency of alleles 3R and 5R of MAOA gene in patients with CA was 30.0%, which doesn’t have any statistical difference with the healthy persons. The genotype frequency of Val158Met of COMT gene is high in CA rather than in healthy persons (χ2 = 6.85, P = 0.03). Also, the homozygotes Val are much more in CA patients (59.1%) than in healthy persons (25%). On the other hand, the Val/Met combination is lower in CA patients (18.2%) than in healthy persons (55.0%).

Conclusion

The Val158Met polymorphism of gene COMT may lead to CA formation.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Type
e-Poster viewing: Genetics & molecular neurobiology
Information
European Psychiatry , Volume 41 , Issue S1: Abstract of the 25th European Congress of Psychiatry , April 2017 , pp. S596
Copyright
Copyright © European Psychiatric Association 2017
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