Hostname: page-component-7b9c58cd5d-g9frx Total loading time: 0 Render date: 2025-03-13T13:39:37.849Z Has data issue: false hasContentIssue false
  • English
  • Français

The hippocampus and depression

Published online by Cambridge University Press:  16 April 2020

Y.I. Sheline ,
B.L. Mittler  and
M.A. Mintun
Y.I. Sheline*
Affiliation:
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO63110, USA Department of Radiology, Washington University School of Medicine, St. Louis, MO63110, USA Department of Neurology, Washington University School of Medicine, St. Louis, MO63110, USA Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO63110, USA
B.L. Mittler
Affiliation:
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO63110, USA
M.A. Mintun
Affiliation:
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO63110, USA Department of Radiology, Washington University School of Medicine, St. Louis, MO63110, USA Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO63110, USA
*
*Corresponding author: WUSM, Box 8134, 660 S. Euclid Ave, St. Louis, MO 63110, USA.
Get access

Summary

The effect of depression on the hippocampus has become the focus of a number of structural and functional neuroimaging studies. In the past two decades, advances in neuroimaging techniques now allow the examination of subtle changes in both regional structure and function that are associated with the pathophysiology of depression. Many studies using 3-dimensional magnetic resonance imaging (MRI) volumetric measurement have reported decreases in hippocampal volume among depressed subjects compared with controls, whereas other studies have not found any volume loss. Differences among studies have been discussed. In some studies, the volume loss appears to have functional significance including an association with memory loss. Furthermore, we have found a trend towards loss of 5-HT2A receptors in the hippocampus using positron emission tomography (PET) to detect regional changes in [18F]altanserin binding. Functional imaging extends the sensitivity and specificity of structural imaging and will lead to a better understanding of affective disorders.

Keywords

DepressionHippocampusNeuroimagingSerotoninVolumetric change
Type
Research Article
Information
European Psychiatry , Volume 17 , Issue S3: A new pharmacology of depression: the concept of synaptic plasticity , July 2002 , pp. 300s - 305s
Copyright
Copyright Éditions scientifiques et médicales Elsevier SAS 2002

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Footnotes

To be presented at ECNP Barcelona, 5-9 October 2002, during the symposium “A new pharmacology of depression: the concept of synaptic plasticity.”

References

Ashtari, MGreenwald, BSKramer-Ginsberg, EHu, JWu, HPatel, Met al. Hippocampal/amygdala volumes in geriatric depression. Psychol M 1999;29:629–638.CrossRefGoogle ScholarPubMed
Attar-Levy, DMartinot, JLBlin, JDao-Castellana, MHCrouzel, CMazoyer, Bet al. The cortical serotonin2receptors studied with positron emission tomography and [18F]-septoperone during depressive illness and antidepressant treatment with clomipramine. Biol Psychiatry 1999;45:180–186.CrossRefGoogle Scholar
Axelson, DADoraiswamy, PMMcDonald, WMBoyko, OBTupler, LAPatterson, LJet al. Hypercortisolemia and hippocampal changes in depression. Psychiatry Res 1993;47:163–173.CrossRefGoogle ScholarPubMed
Biver, FWikler, DLotstra, FDamhaut, PGoldman, SMendlewicz, JSerotonin 5-HT2 receptor imaging in major depression: focal changes in orbito-insular cortex. Br J Psychiatry 1997;171:444–448.CrossRefGoogle ScholarPubMed
Bookheimer, SYStrojwas, MHCohen, MSSaunders, AMPericak-Vance, MAMazziotta, JCet al. Patterns of brain activation in people at risk for Alzheimer's disease. N Engl J M 2000;343:450–456.CrossRefGoogle ScholarPubMed
Bowley, MPDrevets, WCOngur, DPrice, JLGlial changes in the amygdala and entorhinal cortex in mood disorders. Abstr Soc Neurosci 2000;26:876–876 10.Google Scholar
Bremner, JDNarayan, MAnderson, ERStaib, LHMiller, HLCharney, DSet al. Hippocampal volume reduction in major depression. Am J Psychiatry 2000;157:115–118.CrossRefGoogle ScholarPubMed
Burt, DBZembar, MJNiederehe, GDepression and memory impairment: a meta-analysis of the association, its pattern, and specificity. Psychol Bull 1995;17:285–305.CrossRefGoogle Scholar
Dupont, RMJernigan, TLHeindel, WButters, NShafer, KWilson, Tet al. Magnetic resonance imaging and mood disorders — localization of white matter and other subcortical abnormalities. Arch Gen Psychiatry 1995;52:747–755.CrossRefGoogle ScholarPubMed
Hamilton, MA rating scale for depression. J Neurol Neurosurg Psychiatry 1960;23:56–62.CrossRefGoogle ScholarPubMed
Killiany, RJMoss, MBAlbert, MSSandor, TTieman, JJolesz, FTemporal lobe regions on magnetic resonance imaging identify patients with early Alzheimer's disease. Arch Neurol 1993;50:949–954.CrossRefGoogle ScholarPubMed
Killiany, RJGomez-Isla, TMoss, MBKikinis, RSandor, TJolesz, Fet al. Use of structural magnetic resonance imaging to predict who will get Alzheimer's disease. Ann Neurol 2000;47:430–439.3.0.CO;2-I>CrossRefGoogle ScholarPubMed
Mann, JJMalone, KMDiehl, DJPerel, JCooper, TBMinutn, MADemonstration in vivo of reduced serotonin responsivity in the brain of untreated depressed patients. Am J Psychiatry 1996;153:174–182.Google ScholarPubMed
McCarley, RWWible, CGFrumin, MHirayasu, YLevitt, JJFischer, IAet al. MRI anatomy of schizophrenia. Biol Psychiatry 1999;45:1099–1119.Google ScholarPubMed
Mervaala, EFohr, JKononen, MValkonen-Korhonen, MVainio, PPartanen, Ket al. Quantitative MRI of the hippocampus and amygdala in severe depression. Psychol M 2000;30:117–125.CrossRefGoogle ScholarPubMed
Meyer, JHKapur, SHoule, SDaSilva, JOwczarek, BBrown, GMet al. Prefrontal cortex 5-HT2 receptors in depression: an 〚18F〛setoperone PET imaging study. Am J Psychiatry 1999;156:1029–1034.Google Scholar
Mintun, MASheline, YIMoerlein, SMVlassenko, AGSnyder, AZDecreased hippocampal in vivo 5-HT2A receptor binding in depression. Abstr Soc Neurosci 2001Google Scholar
Pantel, JSchroder, JEssig, MPopp, DDech, HKnopp, MVet al. Quantitative magnetic resonance imaging in geriatric depression and primary degenerative dementia. J Affect Disord 1997;42:69–83.CrossRefGoogle ScholarPubMed
Shah, PJEbmeier, KPGlabus, MFGoodwin, GMCortical grey matter reductions associated with treatment-resistant chronic unipolar depression. Controlled magnetic resonance imaging study. Br J Psychiatry 1998;172:527–532.CrossRefGoogle ScholarPubMed
Sheline, YWang, PGado, MCsernansky, JVannier, MHippocampal atrophy in recurrent major depression. Proc Natl Acad Sci USA 1996;93:3908–3913.CrossRefGoogle ScholarPubMed
Sheline, YSanghavi, MMintun, MGado, MDepression duration but not age predicts hippocampal volume loss in women with recurrent major depression. J Neurosci 1999;19:5034–5043.CrossRefGoogle Scholar
Small, GWErcoli, LMSilverman, DHHuang, SCKomo, SBrookheimer, SYet al. Cerebral metabolic and cognitive decline in persons at genetic risk for Alzheimer's disease. Proc Natl Acad Sci USA 2000;97:6037–6042.CrossRefGoogle ScholarPubMed
Swayze, VWAndreasen, NCAlliger, RJYuh, WTCEhrhard, JCSubcortical and temporal structures in affective disorder and schizophrenia: a magnetic resonance imaging study. Biol Psychiatry 1992;31:221–240.CrossRefGoogle ScholarPubMed
Vakili, KPillay, SSLafer, BFava, MRenshaw, PFBonello-Cintron, CMet al. Hippocampal volume in primary unipolar major depression: a magnetic resonance imaging study. Biol Psychiatry 2000;47:1087–1090.CrossRefGoogle ScholarPubMed
Velakoulis, DPantelis, CMcGorry, PDDudgeon, PBrewer, WCook, Met al. Hippocampal volume in first-episode psychoses and chronic schizophrenia. Arch Gen Psychiatry 1999;56:133–140.CrossRefGoogle ScholarPubMed
Yatham, LNLiddle, PFShiah, ISScarrow, GLam, RWAdam, MJet al. Brain serotonin2 receptors in major depression. A positron emission tomography study. Arch Gen Psychiatry 2000;57:850–858.CrossRefGoogle ScholarPubMed
Submit a response

Comments

No Comments have been published for this article.