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A historical cohort study of kidney damage in long-term lithium patients: continued surveillance needed

Published online by Cambridge University Press:  16 April 2020

H. Bendz ,
M. Aurell  and
J. Lanke
H. Bendz*
Affiliation:
Department of Clinical Neuroscience, Psychiatry section, Lund University, Lund, Sweden;
M. Aurell
Affiliation:
Department of Nephrology, Gothenburg University, Gothenburg, Sweden;
J. Lanke
Affiliation:
Department of Statistics, Lund University, Lund, Sweden
*
*Correspondence and reprints: Department of Psychiatry, University Hospital, S-221 85 Lund, Sweden
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Summary

Background

Insufficient knowledge on the longitudinal fate of renal function in lithium patients incited this retrospective study of 149 patients.

Method

Medical record review of a lithium cohort (N = 149), 8–12 years after an initial renal function study.

Results

Twenty-one patients had died, one from uremia probably not caused by lithium, and 42 had discontinued lithium. Reduced urinary concentrating capacity (Umax) or glomerular filtration rate (GFR) was not more frequent among deceased or off-lithium patients than among the 86 patients who were on lithium at follow-up. In 63 of the latter patients, Umax had been re-examined after the initial study, and GFR in 29 patients. Reduced Umax and GFR had become twice as common, and average Umax and GFR had decreased significantly. The reduction of GFR was associated with lithium treatment duration and age, and reduced Umax with treatment duration only.

Conclusions

Reduced renal function is not a major cause of treatment discontinuation but becomes increasingly common with treatment duration.

Keywords

lithiumlongitudinal studynephropathyrenal functionside effects
Type
Original article
Information
European Psychiatry , Volume 16 , Issue 4 , June 2001 , pp. 199 - 206
Copyright
Copyright © Éditions scientifiques et médicales Elsevier SAS 2001

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