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The impact of social cognition deficits on real life functioning in 22q11.2 deletion syndrome: A comparative study with a large population of patients with schizophrenia

Published online by Cambridge University Press:  13 August 2021

T. Accinni ,
M. Frascarelli ,
A. Buzzanca ,
F. Ghezzi ,
L. Carlone ,
A. Panzera ,
A. Moschillo ,
N. Girardi  and
F. Di Fabio
T. Accinni*
Affiliation:
Department Of Human Neurosciences Sapienza University Of Rome, Viale dell’Università 30, Rome, Italy
M. Frascarelli
Affiliation:
Department Of Human Neurosciences Sapienza University Of Rome, Viale dell’Università 30, Rome, Italy
A. Buzzanca
Affiliation:
Department Of Human Neurosciences Sapienza University Of Rome, Viale dell’Università 30, Rome, Italy
F. Ghezzi
Affiliation:
Department Of Human Neurosciences Sapienza University Of Rome, Viale dell’Università 30, Rome, Italy
L. Carlone
Affiliation:
Department Of Human Neurosciences Sapienza University Of Rome, Viale dell’Università 30, Rome, Italy
A. Panzera
Affiliation:
Department Of Human Neurosciences Sapienza University Of Rome, Viale dell’Università 30, Rome, Italy
A. Moschillo
Affiliation:
Department Of Human Neurosciences Sapienza University Of Rome, Viale dell’Università 30, Rome, Italy
N. Girardi
Affiliation:
Department Of Human Neurosciences Sapienza University Of Rome, Viale dell’Università 30, Rome, Italy
F. Di Fabio
Affiliation:
Department Of Human Neurosciences Sapienza University Of Rome, Viale dell’Università 30, Rome, Italy
*
*Corresponding author.

Abstract

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Introduction

22q11.2 Deletion Syndrome (22q11.2DS) represents a congenital syndrome with several clinical features. It entails a 25% risk of psychotic onset in lifespan. 22q11.2DS is a reliable model for biological vulnerability to schizophrenia.

Objectives

With the hypothesis of similar impairments in schizophrenia and 22q11DS, to investigate a possible correlation between Social Cognition (SC) and Interpersonal Functioning (FU).

Methods

Sample consists of 1735 adults: 893 schizophrenic subjects (SCZ); 18 with 22q11.2DS and psychosis (DEL_SCZ); 44 22q11.2DS individuals (DEL); 780 healthy controls (HC). SCZ and HC data come from a multicentric study by Network for Research on Psychoses. SC was assessed with The Awareness of Social Interference Test (TASIT, consisting of three sections: T1= Emotion Recognition; T2=Minimal Social Inference; T3=Social Inference Enriched). The Specific Levels of Functioning (SLOF) interview was employed.

Results

DEL_SCZ (p<0.001) and SCZ (p<0.001) showed impairments in each TASIT sections compared to HC. Significant deficits in interpersonal functioning area were found in SCZ (p<0.001) compared to HC. The interpersonal functioning domain showed a positive correlation with SC in HC (T1: r=0.097; p<0.001; T2: r=0.120; p=0.001; T3: r=0.121; p=0.001); DEL (T1: r=0.380; p=0.024; T2: r=0.466; p=0.005) and SCZ (T1: r=0.113, p=0.001; T2: r=0.110, p=0.001; T3: r=0.134; p<0.001).

Conclusions

SC deficits both in subjects with 22q11.2DS and in people with schizophrenia suggest a role of endophenotypes. SC is directly correlated to interpersonal functioning in 22q11.2DS without psychosis and people with schizophrenia. DEL_SCZ may suffer from deeper cognitive and symptomatic conditions that both impact differently on FU.

Keywords

22q11.2 Deletion Syndromesocial cognitionschizophréniaReal life functioning
Type
Abstract
Information
European Psychiatry , Volume 64 , Special Issue S1: Abstracts of the 29th European Congress of Psychiatry , April 2021 , pp. S541 - S542
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of the European Psychiatric Association
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