Hostname: page-component-78c5997874-xbtfd Total loading time: 0 Render date: 2024-11-10T11:58:26.817Z Has data issue: false hasContentIssue false
  • English
  • Français

Impaired response inhibition in obsessive compulsive disorder

Published online by Cambridge University Press:  28 November 2006

R. Penadés ,
R. Catalán ,
K. Rubia ,
S. Andrés ,
M. Salamero  and
C. Gastó
R. Penadés*
Affiliation:
Clinical Institute of Neurosciences, Hospital Clínic, C/ Villarroel 170, 08036Barcelona, Spain
R. Catalán
Affiliation:
Clinical Institute of Neurosciences, Hospital Clínic, C/ Villarroel 170, 08036Barcelona, Spain
K. Rubia
Affiliation:
Institute of Psychiatry, King’s College, London, UK
S. Andrés
Affiliation:
Clinical Institute of Neurosciences, Hospital Clínic, C/ Villarroel 170, 08036Barcelona, Spain
M. Salamero
Affiliation:
Clinical Institute of Neurosciences, Hospital Clínic, C/ Villarroel 170, 08036Barcelona, Spain
C. Gastó
Affiliation:
Clinical Institute of Neurosciences, Hospital Clínic, C/ Villarroel 170, 08036Barcelona, Spain
*
∗Corresponding author. Tel./fax: +34 93 227 54 77. E-mail address: rpenades@clinic.ub.es (R. Penadés).
Get access

Abstract

Objective

The present study investigates different three inhibitory control functions in patients with obsessive-compulsive disorder (OCD). Selective motor response inhibition was tested in a GO/NO-GO paradigm, the inhibition of a triggered motor response in a STOP paradigm and the ability to inhibit cognitive interference in a motor STROOP paradigm.

Methods

27 patients who met DSM-IV criteria for OCD and 25 age, handedness and IQ-matched healthy control subjects were tested in the GO/NO-GO, STOP and motor STROOP tasks.

Results

OCD patients performed significantly worse than controls in the selective inhibition of their motor responses (GO/NO-GO) and in the inhibition of cognitive interference (STROOP), and also showed worse performance in suppressing previously triggered motor responses (STOP).

Conclusion

Patients with OCD are impaired in motor and cognitive inhibitory mechanisms. The findings are consistent with psychobiological and neuropsychological models of OCD suggesting impairment of frontostriatal circuitries that mediate functions of inhibitory control.

Keywords

Obsessive compulsive disorderGO/NO-GO taskSTOP taskSTROOP taskCognitive inhibitionMotor response inhibition
Type
Original article
Information
European Psychiatry , Volume 22 , Issue 6 , September 2007 , pp. 404 - 410
Copyright
Copyright © Elsevier Masson SAS 2007

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

American Psychiatric Association Diagnostic and statistical manual of mental disorders. 4th ed. Washington, DC: Author; 1994.Google Scholar
Band, G.P., Van der Molen, M.W., Logan, G.D.Horse-race model simulations of the stop-signal procedure. Acta Psychol 2003;112(2):105–142.CrossRefGoogle ScholarPubMed
Banich, M.T., Milham, M.P., Atchley, R., Cohen, N.J., Webb, A., Wszalek, T.et al.fMRI studies of Stroop tasks reveal unique roles of anterior and posterior brain systems in attentional selection. J Cognitive Neurosci 2000;12:988–1000.CrossRefGoogle ScholarPubMed
Bannon, S., Gonsalvez, C.J., Croft, R.J., Boyce, P.M.Response inhibition deficits in obsessive-compulsive disorder. Psychiatry Res 2002;110:165–174.CrossRefGoogle ScholarPubMed
Baxter, L.E., Phelps, E.A., Mazziotta, J.C., Guze, B.H., Schwartz, J.M., Selin, C.E.Local cerebral glucose metabolic rates in obsessive-compulsive disorder: a comparison with rates in unipolar depression in normal controls. Arch Gen Psychiat 1987;44:211–218.CrossRefGoogle ScholarPubMed
Baxter, L.E., Schwartz, J.M., Mazziotta, J.C., Phelps, M.E., Pahl, J.J., Guze, B.H.et al.Cerebral glucose metabolic rates in non-depressed obsessive-compulsives. Am J Psychiatry 1988;145:1560–1563.Google Scholar
Baxter, L.R., Ackermann, R.F., Swerdlow, N.R., Brody, A., Saxena, S., Scwartz, J.M.et al.Specific brain system mediation of obsessive-compulsive disorder responsive to either medication or behavior therapy. In: Goodman, W.K., Rudorfer, M.V., editros. Obsessive-compulsive disorder: contemporary issues in treatment Mahway, NJ: Lawrence Erlbaum Associates, Inc. Black, H.; 2000. p. 573–609.Google Scholar
Beck, A.T., Ward, C.H., Mendelson, M., Erbaugh, J.An inventory for measuring depression. Arch Gen Psychiat 1961;4:561–571.CrossRefGoogle ScholarPubMed
Berthier, M.L., Kulisevsky, J.J., Gironell, A., Lopez, O.L.Obsessive compulsive disorder and traumatic brain injury: behavioral, cognitive, and neuroimaging findings. Neuropsychiatry Neuropsychol Behav Neurol 2001;14:23–31.Google ScholarPubMed
Breiter, H.C., Rauch, S.L.Functional MRI and the study of OCD: from symptom provocation to cognitive-behavioral probes of cortico-striatal systems and the amygdala. NeuroImage 1996;4:S127–S138.CrossRefGoogle Scholar
Cavedini, P., Ferri, S., Scarone, S., Bellodi, L.Frontal lobe dysfunction in obsessive-compulsive disorder and major depression: a clinical-neuropsychological study. Psychiatry Res 1998;78:21–28.CrossRefGoogle ScholarPubMed
Chamberlain, S.R., Blackwell, A.D., Fineberg, B.A., Robbins, T.W., Sahakian, B.J.The neuropsychology of obsessive compulsive disorder: the importance of failures in cognitive and behavioural inhibition as candidate endophenotypic markers. Neurosci Biobehav Rev 2005;29:399–419.CrossRefGoogle ScholarPubMed
Clayton, I.C., Richards, J.C., Edwards, C.J.Selective attention in obsessive-compulsive disorder. J Abnorm Psychol 1999;108:171–175.CrossRefGoogle ScholarPubMed
Cohen, Y., Rasic, J., Lachenmeyer, I., Springer, C.Anxiety and selective attention in obsessive-compulsive disorder. Behav Res Ther 2003;11:1311–1323.CrossRefGoogle Scholar
Deckersbach, T., Otto, M.W., Savage, C.R., Baer, L., Jenike, M.A.The relationship between semantic organization and memory in obsessive-compulsive disorder. Psychother Psychosom 2000;69:101–107.CrossRefGoogle ScholarPubMed
Deckersbach, T., Savage, C.R., Henin, A., Mataix-Cols, D., Otto, M.W., Wilhem, S.et al.Reliability and validity of a scoring system approach in the complex figure test. J Clin Exp Neuropsyc 2000;22:640–648.CrossRefGoogle ScholarPubMed
Foa, E., Ilai, D., Mccarthy, P.R., Shoyer, B., Murdock, T.Information-processing in obsessive-compulsive disorder. Cognit Ther Res 1993;17:173–189.CrossRefGoogle Scholar
Gambini, O., Abbruzesse, M., Scarone, S.Smooth pursuit and saccadic eye movements and Wisconsin Card Sorting Test performance in obsessive-compulsive disorder. Psychiatry Res 1993;48:191–200.CrossRefGoogle ScholarPubMed
Hartston, H.J., Swerdlow, N.R.Visuospatial priming and Stroop performance in patients with obsessive compulsive disorder. Neuropsychology 1999;13:447–457.CrossRefGoogle ScholarPubMed
Herrman, M.J., Jacob, C., Unterecker, S., Fallgater, J.A.Reduced response-inhibition in obsessive-compulsive disorder measured with topographic evoked potential mapping. Psychiatry Res 2003;120:265–271.CrossRefGoogle Scholar
Johannes, S., Wieringa, B.N., Mantey, M., Nager, W., Rada, D., Müller-Valh, K.R.et al.Altered inhibition of motor responses in Tourette Syndrome and Obsessive-Compulsive Disorder. Acta Neurol Scand 2001;104:36–43.CrossRefGoogle ScholarPubMed
Karadag, F., Oguzhanoglu, N.K., Kurt, T., Oguzhanoglu, A., Atesci, F., Ozdel, O.Quantitative EEG analysis in obsessive compulsive disorder. Int J Neurosci 2003;113:833–847.CrossRefGoogle ScholarPubMed
Kawashima, R., Satoh, K.M., Ioth, H., Ono, S., Furumoto, S., Gotoh, R.et al.Functional anatomy of GO/NO-GO discrimination and response selection- a PET study in man. Brain Res 1996;728:79–89.Google ScholarPubMed
Kim, M.S., Kang, S.S., Youn, T., Kang, D.H., Kim, J.J., Kwon, J.S.Neuropsychological correlates of P300 abnormalities in patients with schizophrenia and obsessive-compulsive disorder. Psychiatry Res 2003;123:109–123.Google ScholarPubMed
Konishi, S., Nakajima, K., Uchida, I., Kikyo, H., Miyashita, Y.Common inhibitory mechanism in human inferior prefrontal cortex revealed by event-related functional MRI. Brain 1999;122:981–991.CrossRefGoogle ScholarPubMed
Konishi, S., Nakajima, K., Uchida, I., Sekihara, K., Miyashita, Y.No-go dominant brain activity in human inferior prefrontal cortex revealed by functional magnetic resonance imaging. Eur J Neurosci 1998;10:1209–1213.CrossRefGoogle ScholarPubMed
Kwon, J.S., Kim, J.J., Lee, D.W., Lee, J.S., Lee, D.S., Kim, M.S.et al.Neural correlates of clinical symptoms and cognitive dysfunctions in obsessive-compulsive disorder. Psychiatry Res-Neuroim 2003;122:37–47.CrossRefGoogle ScholarPubMed
Lacerda, A., Dalgalarrondo, P., Caetano, D., Haas, G.L., Camargo, E.E., Keshavan, M.S.Neuropsychological performance and regional cerebral blood flow in obsessive-compulsive disorder. Prog Neuro-Psychoph 2003;27:657–665.CrossRefGoogle ScholarPubMed
Leckman, J.F., Mayes, L.C.Understanding developmental psychopathology: how useful are evolutionary accounts?. J Am Acad Child Psy 1998;37:1011–1021.CrossRefGoogle ScholarPubMed
Logan, G.D., Schachar, R., Tannock, R.T.Impulsivity and inhibitory control. Psychol Sci 1997;8:60–64.CrossRefGoogle Scholar
Lucey, J.V., Costa, D.C., Busatto, G., Pilowsky, L.S., Marks, I.M., Ell, P.J.et al.Caudate regional cerebral blood flow in obsessive-compulsive disorder, panic disorder and healthy controls on single photon emission computerised tomography. Psychiatry Res Mar 1997;14:25–33.CrossRefGoogle Scholar
Macleod, C.M., Macdonald, P.A.The Stroop effect and attention. Trends Neurosci 2000;4:383–391.Google ScholarPubMed
Mataix-Cols, D., Alonso, P., Menchon, J.M., Vallejo, J.Neuropsychological performance in medicated vs. unmedicated patients with obsessive-compulsive disorder. Psychiatry Res 2002;109:255–256.CrossRefGoogle ScholarPubMed
Mavrogiorgou, P., Juckel, G., Frodl, T., Gallinat, J., Hauke, W., Zaudig, M.et al.P300 subcomponents in obsessive-compulsive disorder. J Psychiat Res 2002;36:399–406.CrossRefGoogle ScholarPubMed
Milliery, M., Bouvard, M., Aupetit, J., Cottraux, J.Sustained attention in patients with obsessive-compulsive disorder: a controlled study. Psychiatry Res 2000;96:199–209.CrossRefGoogle ScholarPubMed
Oades, R.D.Stimulus dimension shifts in patients with schizophrenia, with and without paranoid hallucinatory symptoms, or obsessive compulsive disorder: strategies, blocking and monoamine status. Behav Brain Res 1997;88:115–131.CrossRefGoogle ScholarPubMed
Okasha, A., Raafat, M., Mahallawy, N., El Nahas, G., Seif El Dawla, A., Sayed, M.et al.Cognitive dysfunction in obsessive-compulsive disorder. Acta Psychiatr Scand 2000;101:281–285.Google ScholarPubMed
Purcell, R., Maruff, P., Pantelis, C.Cognitive deficits in obsessive-compulsive disorder on tests of frontal-striatal function. Biol Psychiatry 1998;43:348–357.CrossRefGoogle ScholarPubMed
Purcell, R., Maruff, P., Pantelis, C.Neuropsychological deficits in obsessive-compulsive disorder: a comparison with unipolar depression, panic disorder, and normal controls. Arch Gen Psychiat 1998;55:415–423.CrossRefGoogle ScholarPubMed
Rachman, S., Hodgson, R.Obsessions and compulsions. New York: Prentice Hall; 1980.Google Scholar
Rosenberg, D.R., Averbach, D.H., O'Hearn, K.M., Seymour, A.B., Birmaher, B., Sweeney, J.A.Oculomotor response inhibition abnormalities in pediatric obsessive compulsive disorder. Arch Gen Psychiat 1997;54:831–838.CrossRefGoogle ScholarPubMed
Rubia, K., Oosterlaan, J., Sergeant, J., Brandeis, D., V Leeuwen, T.H.Inhibitory dysfunction in hyperactive boys. Behav Brain Res 1998;94:25–32.CrossRefGoogle ScholarPubMed
Rubia, K., Overmeyer, S., Taylor, E., Brammer, M., Williams, S.R., Simmomns, A.et al.Frontalisation with age: mapping neurodevelopmental trajectories with fMRI. Neurosci Biobehav R 2000;24:13–19.CrossRefGoogle ScholarPubMed
Rubia, K., Russell, T., Overmeyer, S., Brammer, M.J., Bullmore, E.T., Sharma, T.et al.Mapping motor inhibition: conjunctive brain activations across different versions of go/no-go tasks. NeuroImage 2001;13:250–261.CrossRefGoogle Scholar
Rubia, K., Smith, A., Brammer, M., Taylor, E.Right inferior prefrontal cortex mediates response inhibition while mesial prefrontal cortex is responsible for error detection. NeuroImage 2003;20:351–358.Google ScholarPubMed
Rubia, K, Smith, A, Taylor, E.The Maudsley Attention and Response Suppression Task (MARS) battery: a test battery to measure impulsiveness applied to children with Attention Deficit Hyperactivity Disorder (ADHD). Child Neuropsychol, in press.Google Scholar
Rubia, K., Taylor, E., Oksannen, S., Overmeyer, S., Bullmore, E., Newman, S.Neuropsychological analyses of impulsiveness in childhood hyperactivity. Br J Psychiatry 2001;179:138–143.CrossRefGoogle ScholarPubMed
Savage, C.R., Baer, L., Keuthen, N.J., Brown, H.D., Rauch, S.L., Jenike, M.A.Organizational strategies mediate non-verbal memory impairment in obsessive-compulsive disorder. Biol Psychiatry 1999;45:905–916.CrossRefGoogle Scholar
Saxena, S., Rauch, S.L.Functional neuroimaging and the neuroanatomy of obsessive-compulsive disorder. Psychiat Clin North Am 2000;23:563–586.CrossRefGoogle ScholarPubMed
Schmidtke, K., Schorb, A., Winkelmann, G.Hohagen cognitive frontal lobe dysfunction in obsessive-compulsive disorder. Biol Psychiatry 1998;43:666–673.Google ScholarPubMed
Seisdedos, N., Corral, S., Cordero, A., De La Cruz, M.V., Pereña, J.Escala de Inteligencia Wechsler para adultos – III. Madrid. TEA Ediciones 1999.Google Scholar
Serra, F.P., Palma, V., Nolfe, G., Buscaino, G.A.An electrophysiological study in obsessional compulsive disorders. Acta Neurol 1994;16:240–248.Google ScholarPubMed
Stein, D.J., Hollander, E., Simeon, D., Cohen, L., Islam, M.N., Aronowitz, B.Neurological soft signs in female trichotillomania patients, obsessive-compulsive disorder patients, and healthy control subjects. J Neuropsych Clin N 1994;6:184–187.Google ScholarPubMed
Stein, D.J., Ludik, J.A neural network of obsessive-compulsive disorder: cognitive disinhibition and neurotransmitter dysfunction modelling. Med Hypotheses 2000;55:168–176.CrossRefGoogle ScholarPubMed
Stein, D.J.Obsessive-compulsive disorder. Lancet 2002;360:397–405.Google ScholarPubMed
Tallis, F., Pratt, P., Jamani, N.Obsessive compulsive disorder, checking, and non-verbal memory: a neuropsychological investigation. Behav Res Ther 1998;37:161–166.CrossRefGoogle Scholar
Tallis, F.The neuropsychology of obsessive-compulsive disorder: 29review and consideration of clinical implications. Brit J Clin Psychol 1997;36:3–20.Google ScholarPubMed
Terrence, E.N., Haller, E.J.Visual attention in obsessive-compulsive disorder. Psychiatry Res 1993;49:183–196.Google Scholar
Tot, S., Ozge, A., Copmelekoglu, U., Yazici, K., Bal, N.Association of QEEG findings with clinical characteristics of OCD: evidence of left frontotemporal dysfunction. Can J Psychiat 2002;47:538–545.CrossRefGoogle ScholarPubMed
Van Boxtel, G.J., Van der Molen, M.W., Jennings, J.R., Brunia, C.H.A psychophysiological analysis of inhibitory motor control in the stop-signal paradigm. Biol Psychol 2001;58:229–262.CrossRefGoogle ScholarPubMed
Van der Wee, V.M., Ramsey, N.F., Jansma, J.M., Denys, D.A., van Megen, H.G., Westenberg, H.G.et al.Spatial working memory deficits in obsessive compulsive disorder are associated with excessive engagement of the medial frontal cortex. NeuroImage 2003;20:2271–2280.CrossRefGoogle ScholarPubMed
Veale, D.M., Sahakian, B.J., Owen, A.M., Marks, I.Specific cognitive deficits in tests sensitive to frontal lobe dysfunction in obsessive-compulsive disorder. Psychol Med 1996;26:1261–1269.CrossRefGoogle ScholarPubMed
Submit a response

Comments

No Comments have been published for this article.