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The importance of blood count and oxidative stress in the drug-naïve first episode schizophrenia

Published online by Cambridge University Press:  01 September 2022

J. Rog ,
M. Dzikowski ,
D. Juchnowicz ,
N. Waszkiewicz ,
A. Zalewska ,
M. Maciejczyk  and
H. Karakula-Juchnowicz
J. Rog*
Affiliation:
Medical University of Lublin, 1st Department Of Psychiatry, Psychotherapy And Early Intervention, Lublin, Poland
M. Dzikowski
Affiliation:
Medical University of Lublin, 1st Department Of Psychiatry, Psychotherapy And Early Intervention, Lublin, Poland
D. Juchnowicz
Affiliation:
Medical University of Lublin, Department Of Psychiatric Nursing, Lublin, Poland
N. Waszkiewicz
Affiliation:
Medical University of Bialystok, Department Of Psychiatry, Białystok, Poland
A. Zalewska
Affiliation:
Medical University of Bialystok, Experimental Dentistry Laboratory And Department Of Restorative Dentistry, Bialystok, Poland
M. Maciejczyk
Affiliation:
Medical University of Bialystok, Department Of Hygiene, Epidemiology And Ergonomics, Białystok, Poland
H. Karakula-Juchnowicz
Affiliation:
Medical University of Lublin, 1st Department Of Psychiatry, Psychotherapy And Early Intervention, Lublin, Poland
*
*Corresponding author.

Abstract

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Introduction

Schizophrenia (SZ) is associated with changes in haematological parameters related to low-grade inflammation state and could be amplified via oxidative stress (OS) related mechanisms. Although studies confirm this relationship, the results could be cofounded by patients’ treatment.

Objectives

The study aimed to assess the connection between venous blood count and OS in drug-naïve first-episode SZ patients.

Methods

The study consisted of 24 SZ drug-naïve patients during first episode of psychosis (median age: 22 years), and 31 healthy individuals (HC) as a control group (median age: 28 years). The examination included clinical data, OS parameters (enzymatic and non-enzymatic antioxidants), peripheral blood counts.

Results

We did not find differences between SZ and HC in blood count parameters (p>0.05). In patients group, white blood cells (WBC), neutrophils and neutrophils-to-lymphocyte ratio (NLR) were positively related with the severity of positive symptoms (R=0.59, R=0.53, R=0.50; p<0.05, respectively). WBC was related to superoxide dismutase (SOD-1) levels (HC: R=-0.36, SZ: R=0.70; p<0.05). Neutrophils were positively related to catalase (CAT) (R=0.52; p<0.05) and ferric reducing antioxidant power (FRAP) (R=0.61; p<0.05), but only in the patients’ group. There was a positive relationship between NLR and CAT (R=0.45; p<0.05) in the SZ group.

Conclusions

The results indicate potential connection and interplay between OS and blood count parameters in the onset of psychotic episode. Further studies on a larger group of patients are needed.

Disclosure

No significant relationships.

Keywords

Oxidative stressFirst Episode Psychosiswhite blood cellsdrug-naïve
Type
Abstract
Information
European Psychiatry , Volume 65 , Special Issue S1: Abstracts of the 30th European Congress of Psychiatry , June 2022 , pp. S793
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of the European Psychiatric Association
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