Hostname: page-component-78c5997874-g7gxr Total loading time: 0 Render date: 2024-11-10T13:41:18.317Z Has data issue: false hasContentIssue false
  • English
  • Français

Increased serum drug concentrations in concomitant treatment with citalopram, clomipramine and alprazolam

Published online by Cambridge University Press:  16 April 2020

U Lepola ,
E Leinonen  and
H Koponen
U Lepola
Affiliation:
Psychiatric Research Clinic of Kuopio, Asemakatu 46 B, SF-70110Kuopio
E Leinonen
Affiliation:
Psychiatric Research Clinic of Kuopio, Asemakatu 46 B, SF-70110Kuopio
H Koponen
Affiliation:
Moisio Hospital, Mikkeli, Finland
Get access

Summary

We report the case of a patient with major depression and obsessive-compulsive disorder who had simultaneously high serum citalopram, clomipramine, and alprazolam concentrations probably due to the reciprocal competitive inhibition of the cytochrome P450-catalyzed oxidative metabolism.

Keywords

alprazolamcitalopramclomipraminecytochrome P450drug interaction
Type
Case report
Information
European Psychiatry , Volume 9 , Issue 6 , 1994 , pp. 312 - 314
Copyright
Copyright © European Psychiatric Association 1994

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Antal, EJEreshefsky, LWells, BEvans, RLRichards, ALTownsend, RJSmith, RBMulti-center evaluation of the kinetic and clinical interaction of alprazolam and imipramine Clin Pharmacol Ther 1986;39:178Google Scholar
Brosen, KCytochrom P450 gen-superfamiliens betydning for laegemidlers kliniske farmakokinetik Ugeskr Laeg 1991;153: 417-22Google Scholar
Brosen, KIsozyme specific drug oxidation: genetic polymorphism and drug-drug interactions Nord J Psychiatry 1993:47 (suppl 30):21-6CrossRefGoogle Scholar
Crewe, HKLennard, MSTucker, GTWoods, FRHaddock, REThe effect of selective serotonin re-uptake inhibitors on cytochrome P4502D6 (CYP2D6) activity in human liver microsomes Br J Clin Pharmacol 1992;34: 262-5CrossRefGoogle ScholarPubMed
Fredricsson-Overo, K The Role of Pharmacokinetics in the Development of New Drugs: an Illustration by Studies on Citalopram. Department of Biochemistry. H Lundbeck A/S, Copenhagen. Thesis, 1986Google Scholar
Goodman, WKMcDougle, CJPrice, LHPharmacotherapy of obsessive-compulsive disorder J Clin Psychiatry 1992;53 (suppl 4):29-37Google ScholarPubMed
Greenblatt, DJvon Moltke, LLHarmatz, JSCiraulo, DAShader, RIAlprazolam pharmacokinetics, metabolism, and plasma levels: clinical implications J Clin Psychiatry 1993;54 (suppl 10):4-11Google ScholarPubMed
Lin, WFrade, PSimultaneous quantification of eight tricyclic antidepressants in serum by high performance liquid chromatography Ther Drux Monit 1987;9: 448-55CrossRefGoogle Scholar
Montgomery, SAThe place of obsessive compulsive disorder in the diagnostic hierarchy Int Clin Psychopharmacol 1992;7 (suppl 1): 19–23CrossRefGoogle ScholarPubMed
Preskorn, SHSimpson, STricyclic antidepressant-induced delirium and plasma drug concentrations Am J Psychiatry 1982; 139:822-3Google Scholar
Zohar, JZohar-Kadouch, RCKindler, SCurrent concepts in the pharmacological treatment of obsessive compulsive disorder Drugs 1992;43: 210-8CrossRefGoogle ScholarPubMed
Submit a response

Comments

No Comments have been published for this article.