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Inflammatory cytokines during a manic episode in bd patients and its correlation with cognitive and affective symptoms at follow-up

Published online by Cambridge University Press:  13 August 2021

M. Estudillo Guerra ,
G. Torres Suarez ,
I. Mesia-Toledo ,
K. Pacheco-Barrios  and
J. Ramírez-Bemúdez
M. Estudillo Guerra*
Affiliation:
Research Institute, Spaulding Rehabilitation Hospital and Massachusetts General Hospital, Harvard Medical School, Charlestown, United States of America
G. Torres Suarez
Affiliation:
Psychiatry, Centro Integral de Salud Mental, Mexico City, Mexico
I. Mesia-Toledo
Affiliation:
Research Institute, Spaulding Rehabilitation Hospital and Massachusetts General Hospital, Harvard Medical School, Charlestown, United States of America
K. Pacheco-Barrios
Affiliation:
Neuromodulation Center And Center For Clinical Research Learning, Spaulding Rehabilitation Hospital and Massachusetts General Hospital, Harvard Medical School, Charlestown, United States of America Unidad De Investigación Para La Generación Y Síntesis De Evidencias En Salud, Vicerrectorado de Investigación, Universidad San Ignacio de Loyola, Lima, Peru
J. Ramírez-Bemúdez
Affiliation:
Neuropsychiatry Unit, National Institute of Neurology and Neurosurgery, Mexico City, Mexico
*
*Corresponding author.

Abstract

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Introduction

Bipolar Disorder (BD) is a severe recurrent disorder with a complex biogenetic and psychosocial etiology. The immune system cytokines in interaction with the CNS play a role in the pathophysiology.

Objectives

To compare inflammatory cytokines between BD patients and controls during the manic episode; additionally, compare these cytokines with psychiatric symptoms and cognitive performance during follow-up.

Methods

We recruited 25 BD patients in mania with paired controls. We measured baseline IL-2, IL-4, IL-8, IL-10, GM-CSG, TNF- α, and TNF- γ in plasma. We used U-Mann-Whitney for group comparison and Spearman correlation between sub-group follow-up assessments and cytokines.

Results

We found a significant difference in IL-6 between subjects and controls (figure 1). During the follow-up, we found a correlation with psychiatric symptoms, cognition, and cytokines during manic episodes (Table 1). Table 1. Follow-up Correlation with cytokines during a manic episode.

BD follow-up N=8CytokineMADRSBPRSSCIP-SWMT-SCIP-SPST-SCIP-S
IL-10(-) Rho=-.957 (p=<0.001 R2=0.14).
IL-4(+) Rho=.78 (p=0.02 R2=0.09)
INF- γ(+) Rho=.73 (p=0.03 R2= 0.48)(+) Rho=.751 (p=0.032 R2=0.53)(+) Rho=.737 (p=.037 R2=0.40)
INF- α(+) Rho=.887 (p=.003 R2=0.53),(+) Rho=.830 (p=0.011 R2=0.59)

(+): positive correlation; (-): negative correlation. WMT: working-memory test, PST: Processing-speed test.

Conclusions

IL-6 was significantly different in patients with BD during a manic episode regardless of the treatment they were taking. IL-10 at manic episode was negatively correlated to general psychiatric symptoms, IL-4 positive correlated to depressive symptoms, and cognitive performance was positively correlated to TNF- α and TNF- γ at follow-up.

Disclosure

No significant relationships.

Keywords

cytokinesmaníacognitionbipolar disorder
Type
Abstract
Information
European Psychiatry , Volume 64 , Special Issue S1: Abstracts of the 29th European Congress of Psychiatry , April 2021 , pp. S624 - S625
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of the European Psychiatric Association
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