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Initial evidence for sex-specific effects of early emotional abuse on affective processing in bipolar disorder

Published online by Cambridge University Press:  15 April 2020

M. Russo ,
R. Proujansky ,
A. Gilbert ,
R.J. Braga  and
K.E. Burdick
M. Russo*
Affiliation:
Department of Psychiatry, Mount Sinai School of Medicine, 1, Gustave-L-Levy-Place, Box 1230, 10029New York, USA
R. Proujansky
Affiliation:
Department of Psychiatry, Mount Sinai School of Medicine, 1, Gustave-L-Levy-Place, Box 1230, 10029New York, USA
A. Gilbert
Affiliation:
The Zucker Hillside Hospital, North Shore-Long Island Jewish Health System, Department of Psychiatry Research, Glen Oaks, 1, Gustave-L Levy-PlaceBox 1230, 10029New York, USA
R.J. Braga
Affiliation:
The Zucker Hillside Hospital, North Shore-Long Island Jewish Health System, Department of Psychiatry Research, Glen Oaks, 1, Gustave-L Levy-PlaceBox 1230, 10029New York, USA
K.E. Burdick
Affiliation:
Department of Psychiatry, Mount Sinai School of Medicine, 1, Gustave-L-Levy-Place, Box 1230, 10029New York, USA
*
*Corresponding author. Tel.: +1 212 241 0755; fax: +1 212 996 8931. E-mail address:manuela.russo@mssm.edu (M. Russo).
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Abstract

Purpose

This study investigates the effect of sex and childhood trauma on affective processing in bipolar disorder (BPD) patients.

Methods

In a sample of fifty-six BPD patients, we administered the Childhood Trauma Questionnaire (CTQ), and the Iowa Gambling Task (IGT) and the Affective Go/No-Go (AGNG) to measure affective processing. Analysis of Variance (ANOVA) was used to evaluate the effect of sex and childhood trauma on IGT; Repeated-Measures ANOVAs to measure accuracy and bias measures across conditions on the AGNG.

Results

In the context of childhood abuse, females evidenced a more conservative cognitive style than males by selecting fewer cards from the disadvantageous decks [F(1, 49) = 14.218; P < 0.001] and showed an improvement throughout the task, as noted in a normal learning curve [F(1.49) = 4.385; P = 0.041)]. For the AGNG, an interaction specific to the negative valence stimuli on response bias measures was found. Abused females scored higher (mean = 8.38; SD = 6.39) than abused males (mean = 0.69; SD = 1.19) [F(1.46) = 6.348; P = 0.015].

Conclusion

Severity of childhood trauma was significantly different between sexes. In the context of a history of emotional abuse, male bipolar patients tended toward a more risk-taking behavior compared to female. Further investigations are needed to elucidate potential pathophysiological mechanisms underlying this interaction.

Keywords

Childhood traumaAffective processingBipolar disorderIowa Gambling TestAffective Go/No-Go
Type
Original article
Information
European Psychiatry , Volume 29 , Issue 1 , January 2014 , pp. 52 - 57
Copyright
Copyright © 2013 Elsevier Masson SAS

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