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Interhemispheric functional connectivity in anorexia and bulimia nervosa

Published online by Cambridge University Press:  23 March 2020

R. Amodio ,
A. Prinster ,
A.M. Monteleone ,
F. Esposito ,
A. Canna ,
E. Cantone ,
U. Volpe  and
P. Monteleone
R. Amodio
Affiliation:
Second University of Naples, Department of Psychiatry, Naples, Italy
A. Prinster
Affiliation:
National Research Council, Biostructure and Bioimaging Institute, Naples, Italy
A.M. Monteleone
Affiliation:
Second University of Naples, Department of Psychiatry, Naples, Italy
F. Esposito
Affiliation:
University of Salerno, Department of Medicine and Surgery, Salerno, Italy
A. Canna
Affiliation:
National Research Council, Biostructure and Bioimaging Institute, Naples, Italy
E. Cantone
Affiliation:
University Federico II of Naples, ENT Department, Naples, Italy
U. Volpe
Affiliation:
Second University of Naples, Department of Psychiatry, Naples, Italy
P. Monteleone
Affiliation:
University of Salerno, Department of Medicine and Surgery, Salerno, Italy

Abstract

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Introduction

The functional interplay between brain hemispheres is fundamental for behavioral, cognitive and emotional control. Several pathophysiological aspects of eating disorders (EDs) have been investigated by the use of functional Magnetic Resonance Imaging (fMRI).

Objectives

The objective of the study was to investigate functional brain asymmetry of resting-state fMRI correlations in symptomatic patients with anorexia nervosa (AN) and bulimia nervosa (BN).

Aims

We aimed at revealing whether brain regions implicated in reward, cognitive control, starvation and emotion regulation show altered inter-hemispheric functional connectivity in patients with AN and BN.

Methods

Using resting-state fMRI, voxel-mirrored homotopic connectivity (VMHC) and regional inter-hemispheric spectral coherence (IHSC) analyses in two canonical slow frequency bands (“Slow-5”, “Slow-4”) were studied in 15AN and 13BN patients and 16 healthy controls (HC). Using T1-weighted and diffusion tensor imaging MRI scans, regional VMHC values were correlated with the left-right asymmetry of corresponding homotopic gray matter volumes and with the white matter callosal fractional anisotropy (FA).

Results

Compared to HC, AN patients exhibited reduced VMHC in cerebellum, insula and precuneus, while BN patients showed reduced VMHC in dorso-lateral prefrontal and orbito-frontal cortices. The regional IHSC analysis highlighted that the inter-hemispheric functional connectivity was higher in the ‘Slow-5′Band in all regions except the insula. No group differences in left-right structural asymmetries and in VMHC vs callosal FA correlations were found.

Conclusions

These anomalies indicate that AN and BN, at least in their acute phase, are associated with a loss of inter-hemispheric connectivity in regions implicated in self-referential, cognitive control and reward processing.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Type
e-Poster Viewing: Eating Disorders
Information
European Psychiatry , Volume 41 , Issue S1: Abstract of the 25th European Congress of Psychiatry , April 2017 , pp. S551
Copyright
Copyright © European Psychiatric Association 2017
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