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Less basal thyrotropin levels predict antidepressant response in patients with major depression

Published online by Cambridge University Press:  01 September 2022

R. Navinés ,
G. Oriolo ,
M. Mora ,
M. Cavero ,
E. Gómez-Gil  and
R. Martin-Santos
R. Navinés*
Affiliation:
Hospital Clínic, 1psychiatry And Psychology, Barcelona, Spain
G. Oriolo
Affiliation:
Hospital Clínic, 1psychiatry And Psychology, Barcelona, Spain
M. Mora
Affiliation:
Hospital Clinic, Endocrinology And Nutrition, Barcelona, Spain
M. Cavero
Affiliation:
Hospital Clínic, 1department Of Psychiatry And Psychology, Barcelona, Spain
E. Gómez-Gil
Affiliation:
Hospital Clinic, Endocrinology And Nutrition, Barcelona, Spain
R. Martin-Santos
Affiliation:
Hospital Clínic, 1department Of Psychiatry And Psychology, Barcelona, Spain
*
*Corresponding author.

Abstract

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Introduction

The close association among thyroid metabolism, mood disorders and behavior has long been known. The role of basal thyroid axis in antidepressant treatment response is less known.

Objectives

The aim of the present study was to study the association of basal serum thyrotropin (TSH) levels, with antidepressant treatment response in major depressive disorder.

Methods

Thirty-one depressed adult outpatients were included. Major depressive episode was diagnosed through the MINI (DSM-IV-TR) interview. Clinical symptomatology and blood samples were assessed at baseline, and at 4- and 8-weeks of either escitalopram or sertraline. Treatment response was defined by an improvement ≥50% in MADRS scores at 4-, and 8-weeks. Basal TSH levels were included in a linear regression model as predictor of treatment response.

Results

Twenty-seven patients finished 8-weeks of treatment. Response to treatment was of 74% at 4-weeks, and 63% at 8-weeks of antidepressant treatment. Basal median TSH levels were between normal ranges (M+SD=1.85+1,02 mlU/L). Basal TSH levels not correlated with basal MADRS scores, but with higher MADRS scores at week-4 (r=0,415, p=0,031) and at week-8 (r=0,392, p=0,043). Moreover, less baseline TSH levels trend to be a significant good predictor for treatment response at 4-weeks (R2=.116, p=.083); and a good predictor at 8-weeks treatment (R2=.147, p=.049).

Conclusions

Baseline TSH levels even within the normal range may play a role in predicting antidepressant response.

Disclosure

No significant relationships.

Keywords

tirotrophinmajor depressionantidepressant responseMADRS
Type
Abstract
Information
European Psychiatry , Volume 65 , Special Issue S1: Abstracts of the 30th European Congress of Psychiatry , June 2022 , pp. S257 - S258
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of the European Psychiatric Association
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