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Leukopenia in clozapine treated patients may be induced by other drugs: a case series

Published online by Cambridge University Press:  16 April 2020

Mary Jo Imbarlina ,
Sonali Sarkar ,
Shashi Marwah ,
Haranath Parepally ,
Phillip R. Johnston ,
Jaspreet S. Brar  and
K.N. Roy Chengappa
Mary Jo Imbarlina
Affiliation:
Special Studies Center at Mayview State Hospital
Sonali Sarkar
Affiliation:
Special Studies Center at Mayview State Hospital Western Psychiatric Institute & Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA15213-2593, USA
Shashi Marwah
Affiliation:
Special Studies Center at Mayview State Hospital
Haranath Parepally
Affiliation:
Special Studies Center at Mayview State Hospital Western Psychiatric Institute & Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA15213-2593, USA
Phillip R. Johnston
Affiliation:
Western Psychiatric Institute & Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA15213-2593, USA
Jaspreet S. Brar
Affiliation:
Western Psychiatric Institute & Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA15213-2593, USA
K.N. Roy Chengappa*
Affiliation:
Special Studies Center at Mayview State Hospital Western Psychiatric Institute & Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA15213-2593, USA
*
*Corresponding author. Western Psychiatric Institute & Clinic, University of Pittsburgh, School of Medicine, 3811 O’Hara Street, Pittsburgh, PA 15213-2593, USA. Email address: chengappakn@msx.upmc.edu
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Abstract

The combination of clozapine and other potentially leukopenic drugs may pose a greater risk for neutropenia. However, neutropenia may not always be due to clozapine. When adding potentially leukopenic drugs, clinicians should look for possible alternatives especially as clozapine is often a drug used as the last resort in treatment refractory schizophrenia.

Keywords

LeukopeniaClozapineAgranulocytosisHematopoiesisSchizophrenia
Type
Short communication
Information
European Psychiatry , Volume 19 , Issue 8 , December 2004 , pp. 506 - 509
Copyright
Copyright © European Psychiatric Association 2004

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