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Long-term memory loss and the effects of tianeptine in young and aged mice

Published online by Cambridge University Press:  16 April 2020

C Lebrun  and
R Jaffard
C Lebrun
Affiliation:
Laboratoire de Neurosciences Comportementales et Cognitives, URA CNRS 339, Université de Bordeaux I, Avenue des Facultés, 33405Talence Cedex, France
R Jaffard
Affiliation:
Laboratoire de Neurosciences Comportementales et Cognitives, URA CNRS 339, Université de Bordeaux I, Avenue des Facultés, 33405Talence Cedex, France
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Summary

Previous experiments have shown that tianeptine, a new psychotropic agent with antidepressant properties, improves performance in several learning and memory tasks in mice. In more recent investigations, tianeptine was found to completely alleviate working memory deficits produced by long-term alcohol intoxication and to prevent abnormal memory loss in aged animals (Jaffard et al, 1991b, 1991c). The aim of this paper was to examine how this last finding may be integrated in our understanding of brain mechanisms involved in memory loss. For this purpose, we present a brief review of experimental data and theories which, at different levels of analysis, seems to be relevant to this issue. Together with the subsequent examination of the conditions in which tianeptine was found to improve long-term retention, we suggest that: i) long-term memory loss would be largely determined by the initial encoding of information, so that ii) tianeptine would help aged animals to use spatial mapping or configural associations more efficiently at the time of initial acquisition. This, in turn, suggests that one of the main brain target sites for tianeptine in enhancing memory is the hippocampal formation.

Keywords

tianeptinelong-term memory lossagingmiceencoding strategiesspatial mappinghippocampuspermastore
Type
Research Article
Information
European Psychiatry , Volume 8 , Issue S2: Neuroendocrinological aspects of depression 28 June 1992, Nice, France , 1993 , pp. 81s - 88s
Copyright
Copyright © Elsevier, Paris 1993

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