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Long-term use of benzodiazepines: Definitions, prevalence and usage patterns – a systematic review of register-based studies

Published online by Cambridge University Press:  04 November 2015

T.A.T. Kurko ,
L.K. Saastamoinen ,
S. Tähkäpää ,
A. Tuulio-Henriksson ,
T. Taiminen ,
J. Tiihonen ,
M.S. Airaksinen  and
J. Hietala
T.A.T. Kurko*
Affiliation:
Department of Psychiatry, University of Turku, Turku University Central Hospital and Turku Psychiatry, Kiinamyllynkatu 4-8 (Building 11B), 20521Turku, Finland Clinical Pharmacy Group, Faculty of Pharmacy, University of Helsinki, Viikinkaari 5, 00014Helsinki, Finland
L.K. Saastamoinen
Affiliation:
Research Department, Social Insurance Institution, Nordenskiöldinkatu 12, Helsinki, Finland
S. Tähkäpää
Affiliation:
Clinical Pharmacy Group, Faculty of Pharmacy, University of Helsinki, Viikinkaari 5, 00014Helsinki, Finland
A. Tuulio-Henriksson
Affiliation:
Research Department, Social Insurance Institution, Nordenskiöldinkatu 12, Helsinki, Finland
T. Taiminen
Affiliation:
Department of Psychiatry, University of Turku, Turku University Central Hospital and Turku Psychiatry, Kiinamyllynkatu 4-8 (Building 11B), 20521Turku, Finland
J. Tiihonen
Affiliation:
Department of Clinical Neuroscience, Karolinska Institutet, Karolinska Universitetssjukhuset Solna, 17176Stockholm, Sweden Department of Forensic Psychiatry, University of Eastern Finland, Niuvanniemi Hospital, Kuopio, Finland
M.S. Airaksinen
Affiliation:
Clinical Pharmacy Group, Faculty of Pharmacy, University of Helsinki, Viikinkaari 5, 00014Helsinki, Finland
J. Hietala
Affiliation:
Department of Psychiatry, University of Turku, Turku University Central Hospital and Turku Psychiatry, Kiinamyllynkatu 4-8 (Building 11B), 20521Turku, Finland
*
⁎Corresponding author. Department of Psychiatry, University of Turku, Turku University Central Hospital and Turku Psychiatry, Kiinamyllynkatu 4-8 (Building 11B), 20521 Turku, Finland. Tel.: +358 50 370 79 81. E-mail addresses:terhi.a.kurko@helsinki.fi, terhi.kurko@utu.fi (T.A.T. Kurko).
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Abstract

Background

Numerous treatment guidelines recommend that long-term use of benzodiazepines (BZD) should be avoided primarily due to development of tolerance and a risk for BZD dependence. Despite this, long-term BZD use remains a controversial subject in clinical patient care with “for and against” debates. However, there is no explicit understanding of what is meant by long-term BZD use in real world. The aim of this study was to assess different definitions, usage patterns, prevalence and other characteristics of long-term BZD use based on published register-based studies. Synthesis of these characteristics is essential to derive a meaningful definition of long-term BZD.

Methods

Systematic review of register-based studies on long-term BZD use published in 1994–2014.

Results

Fourty-one studies met our predetermined inclusion criteria. The length of BZD use defined as “long-term” varied in these studies ranging from one month to several years. The most common definition was six months or longer during a year. The prevalence of long-term BZD use in the general population was estimated to be about 3%. The relative proportion of long-term BZD users (all definitions) in adult BZD users ranged from 6% to 76% (mean 24%; 95% CL 13–36%). The estimates were higher in studies only on the elderly (47%; 95% CL 31–64%). Long-term use involved typically steady treatment with low BZD doses. However, in elderly patients long-term BZD use and exceeding recommended doses was relatively common. Several characteristics associated with long-term use were found.

Conclusions

Long-term BZD use is common and a clinical reality. Uniform definitions for “long-term”, which is in line with population-based evidence, is needed to have more comparable results between studies. Our systematic review suggests that duration of BZD treatment over six months, the most common definition for long-term BZD use in the included studies. As also recommended previously, it is a useful starting point for further analyses on disadvantages but also potential advantages associated with long-term BZD use.

Keywords

BenzodiazepinesLong-termUseSystematic reviewAnxiolyticsHypnotics

Information

Type
Review
Information
European Psychiatry , Volume 30 , Issue 8 , November 2015 , pp. 1037 - 1047
Copyright
Copyright © European Psychiatric Association 2020

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References

Donoghue, J.Lader, M.. Usage of benzodiazepines: a review. Int J Psychiatry Clin Pract 2010;14(2):78–87.CrossRefGoogle ScholarPubMed
Lader, M.. Benzodiazepines revisited-will we ever learn?. Addiction 2011;106(12):2086–2109.CrossRefGoogle ScholarPubMed
López-Muñoz, F.Álamo, C.García-García, P.. The discovery of chlordiazepoxide and the clinical introduction of benzodiazepines: half a century of anxiolytic drugs. J Anxiety Disord 2011;25(4):554–562.CrossRefGoogle ScholarPubMed
UK Committee of Safe Medicines. Benzodiazepine dependence and withdrawal symptoms. UK Gov Bullet Prescribing Doctors 1988;21:1–2.Google Scholar
Lader, M.. Benzodiazepine harm: how can it be reduced?. Br J Clin Pharmacol 2014;77(2):295–301.CrossRefGoogle ScholarPubMed
Lader, M.. Effectiveness of benzodiazepines: do they work or not?. Expert Rev Neurother 2008;8(8):1189–1191.CrossRefGoogle ScholarPubMed
Tyrer, P.. Dependence on benzodiazepines. Br J Psychiatry 1980;137(6):576–577.CrossRefGoogle ScholarPubMed
Barker, M.J.Greenwood, K.M.Jackson, M.Crowe, S.F.. Persistence of cognitive effects after withdrawal from long-term benzodiazepine use: a meta-analysis. Arch Clin Neuropsychol 2004;19(3):437–454.CrossRefGoogle ScholarPubMed
Billioti de Gage, S.Moride, Y.Ducruet, T.Kurth, T.Verdoux, H.Tournier, M., et al.Benzodiazepine use and risk of Alzheimer's disease: case-control study. BMJ 2014;349:g5205. http://dx.doi.org/10.1136/bmj.g5205.CrossRefGoogle ScholarPubMed
Huang, W.Muo, C.Chang, S.Chang, Y.Tsai, C.Kao, C.. Benzodiazepine use and risk of stroke: a retrospective population-based cohort study. Psychiatry Clin Neurosci 2014;68(4):255–262.CrossRefGoogle ScholarPubMed
Harnod, T.Lin C-, Sung F-, Kao, C-.. An association between benzodiazepine use and occurrence of benign brain tumors. J Neurol Sci 2014;336(1–2):8–12.CrossRefGoogle ScholarPubMed
Zandstra, S.M.Furer, J.W.van de Lisdonk, E.H.van’t Hof, M.Bor, J.H.J.van Weel, C., et al.Different study criteria affect the prevalence of benzodiazepine use. Soc Psychiatry Psychiatr Epidemiol 2002;37(3):139–144.CrossRefGoogle ScholarPubMed
Schneeweiss, S.Avorn, J.. A review of uses of health care utilization databases for epidemiologic research on therapeutics. J Clin Epidemiol 2005;58(4):323–337.CrossRefGoogle ScholarPubMed
Motheral, B.Brooks, J.Clark, M.A.Crown, W.H.Davey, P.Hutchins, D., et al.A checklist for retrospective database studies – report of the ISPOR task force on retrospective databases. Value Health 2003;6(2):90–97.CrossRefGoogle ScholarPubMed
Solomon, D.J.Henry, R.C.Hogan, J.G.Van Amburg, G.H.Taylor, J.. Evaluation and implementation of public health registries. Public Health Rep 1991;106(2):142–150.Google ScholarPubMed
Benson, K.Hartz, A.J.. A comparison of observational studies and randomized, controlled trials. N Engl J Med 2000;342(25):1878–1886.CrossRefGoogle ScholarPubMed
Sund, R.Methodological perspectives for register-based health system performance assessment: developing a hip fracture monitoring system in Finland; 2008.Google Scholar
Hallas, J.. Drug utilization statistics for individual-level pharmacy dispensing data. Pharmacoepidemiol Drug Saf 2005;14(7):455–463.CrossRefGoogle ScholarPubMed
Soumerai, S.B.Simoni-Wastila, L.Singer, C.Mah, C.Gao, X.Salzman, C., et al.Lack of relationship between long-term use of benzodiazepines and escalation to high dosages. Psychiatr Serv 2003;54(7):1006–1011.CrossRefGoogle ScholarPubMed
Haukka, J.Suvisaari, J.Tuulio-Henriksson, A.Lönnqvist, J.. High concordance between self-reported medication and official prescription database information. Eur J Clin Pharmacol 2007;63(11):1069–1074.CrossRefGoogle ScholarPubMed
WHO Collaborating Centre for Drug Statistics Methodology, Norwegian Institute of Public Health. ATC/DDD Index 2014; 2014, http://www.whocc.no/atc_ddd_index/,accessed December 18, 2014.Google Scholar
Dold, M.Li, C.Tardy, M.Khorsand, V.Gillies, D.Leucht, S.Benzodiazepines for schizophrenia. Cochrane Database Syst Rev 2012;11 [Online].Google Scholar
Smith, A.J.Tett, S.E.. Improving the use of benzodiazepines – is it possible? A non-systematic review of interventions tried in the last 20 years. BMC Health Serv Res 2010;10:321.CrossRefGoogle ScholarPubMed
Mugunthan, K.McGuire, T.Glasziou, P.. Minimal interventions to decrease long-term use of benzodiazepines in primary care: A systematic review and meta-analysis. Br J Gen Pract 2011;61(590):e573–e578.CrossRefGoogle ScholarPubMed
Fisher, J.Sanyal, C.Frail, D.Sketris, I.. The intended and unintended consequences of benzodiazepine monitoring programmes: a review of the literature. J Clin Pharm Ther 2012;37(1):7–21.CrossRefGoogle ScholarPubMed
Lavallée, M.Robillard, P.Mirsalari, R.. Performing systematic literature reviews with novices: an iterative approach. IEEE Trans Educ 2014;57(3):175–181.CrossRefGoogle Scholar
Cunningham, C.M.Hanley, G.E.Morgan, S.. Patterns in the use of benzodiazepines in British Columbia: examining the impact of increasing research and guideline cautions against long-term use. Health Policy 2010;97(2–3):122–129.CrossRefGoogle ScholarPubMed
Bartlett, G.Abrahamowicz, M.Tamblyn, R.Grad, R.Capek, R.du Berger, R.. Longitudinal patterns of new Benzodiazepine use in the elderly. Pharmacoepidemiol Drug Saf 2004;13(10):669–682.CrossRefGoogle ScholarPubMed
Rojas-Fernandez, C.H.Carver, D.Tonks, R.. Population trends in the prevalence of benzodiazepine use in the older population of Nova Scotia: a cause for concern?. Can J Clin Pharmacol 1999;6(3):149–156.Google ScholarPubMed
Thomson, M.Smith, W.A.. Prescribing benzodiazepines for noninstitutionalized elderly. Can Fam Physician 1995;41:792–798.Google ScholarPubMed
Halme, A.S.Beland, S.Preville, M.Tannenbaum, C.. Uncovering the source of new benzodiazepine prescriptions in community-dwelling older adults?. Int J Geriatr Psychiatry 2013;28(3):248–255.CrossRefGoogle Scholar
Preville, M.Bosse, C.Vasiliadis, H.M.Voyer, P.Laurier, C.Berbiche, D., et al.Correlates of potentially inappropriate prescriptions of benzodiazepines among older adults: results from the ESA study. Can J Aging 2012;31(3):313–322.CrossRefGoogle ScholarPubMed
Bell, C.M.Fischer, H.D.Gill, S.S.Zagorski, B.Sykora, K.Wodchis, W.P., et al.Initiation of benzodiazepines in the elderly after hospitalization. J Gen Int Med 2007;22(7):1024–1029.CrossRefGoogle ScholarPubMed
Neutel, C.I.Maxwell, C.J.. The benzodiazepine treadmill – does one prescription lead to more?. Pharmacoepidemiol Drug Saf 1996;5(1):39–42.3.0.CO;2-N>CrossRefGoogle Scholar
Egan, M.Moride, Y.Wolfson, C.Monette, J.. Long term continuous use of benzodiazepines by older adults in Quebec: prevalence, incidence and risk factors. J Am Geriatr Soc 2000;48(7):811–816.CrossRefGoogle Scholar
Fortin, D.Préville, M.Ducharme, C.Hébert, R.Trottier, L.Grégoire, J., et al.Factors associated with long-term benzodiazepine use among elderly women and men in Quebec. J Women Aging 2007;19(3–4):37–52.CrossRefGoogle ScholarPubMed
Van Eijk, J.T.M.Bosma, H.Jonkers, C.C.M.Lamers, F.Muijrers, P.E.M.Prescribing antidepressants and benzodiazepines in the Netherlands: is chronic physical illness involved?. Depress Res Treat 2010.CrossRefGoogle ScholarPubMed
Stuffken, R.Van Hulten, R.P.Heerdink, E.R.Movig, K.L.L.Egberts, A.C.G.. The impact of hospitalisation on the initiation and long-term use of benzodiazepines. Eur J Clin Pharmacol 2005;61(4):291–295.CrossRefGoogle ScholarPubMed
Van Hulten, R.Leufkens, H.G.Bakker, A.. Usage patterns of benzodiazepines in a Dutch community: a 10-year follow-up. Pharm World Sci 1998;20(2):78–82.CrossRefGoogle Scholar
Willems, I.A.T.Gorgels, Wim, J.M.J.Voshaar, R.C.O.Mulder, J.Lucassen, , et al.Tolerance to benzodiazepines among long-term users in primary care. Fam Pract 2013;30(4):404–410.CrossRefGoogle ScholarPubMed
Luijendijk, H.J.Tiemeier, H.Hofman, A.Heeringa, J.Stricker, B.H.C.. Determinants of chronic benzodiazepine use in the elderly: a longitudinal study. Br J Clin Pharmacol 2008;65(4):593–599.CrossRefGoogle ScholarPubMed
Van Hulten, R.Teeuw, K.B.Bakker, A.Leufkens, H.G.. Initial 3-month usage characteristics predict long-term use of benzodiazepines: an 8-year follow-up. Eur J Clin Pharmacol 2003;58(10):689–694.CrossRefGoogle ScholarPubMed
Zandstra, S.M.van Rijswijk, E.Rijnders, C.A.T.van de Lisdonk, E.H.Bor, J.H.J.van Weel, C., et al.Long-term benzodiazepine users in family practice: differences from short-term users in mental health, coping behaviour and psychological characteristics. Fam Pract 2004;21(3):266–269.CrossRefGoogle ScholarPubMed
Bramness, J.G.Sexton, J.A.. The basic pharmacoepidemiology of benzodiazepine use in Norway 2004-9. Norsk Epidemiologi 2011;21(1):35–41.CrossRefGoogle Scholar
Kjosavik, S.R.Ruths, S.Hunskaar, S.. Use of addictive anxiolytics and hypnotics in a national cohort of incident users in Norway. Eur J Clin Pharmacol 2012;68(3):311–319.CrossRefGoogle Scholar
Tvete, I.F.Bjørner, T.Aursnes, I.A.Skomedal, T.. A 3-year survey quantifying the risk of dose escalation of benzodiazepines and congeners to identify risk factors to aid doctors to more rationale prescribing. BMJ Open 2013;3:10.CrossRefGoogle ScholarPubMed
Neutel, C.I.Skurtveit, S.Berg, C.. What is the point of guidelines?. Benzodiazepine and z-hypnotic use by an elderly population. Sleep Med 2012;13(7):893–897.CrossRefGoogle ScholarPubMed
Nordfjærn, T.. A population-based cohort study of anxiety, depression, sleep and alcohol outcomes among benzodiazepine and z-hypnotic users. Addictive Behaviors 2012;37(10):1151–1157.CrossRefGoogle ScholarPubMed
Hsiao, F.Hsieh, P.Gau, C.. Ten-year trend in prescriptions of z-hypnotics among the elderly: a nationwide, cross-sectional study in Taiwan. J Clin Gerontol Geriatr 2013;4(2):37–41.CrossRefGoogle Scholar
Fang, S.Chen, C.Chang, I.Chia-Hsuan Wu, E.Chang, C.Lin, K.. Predictors of the incidence and discontinuation of long-term use of benzodiazepines: a population-based study. Drug Alcohol Depend 2009;104(1–2):140–146.CrossRefGoogle ScholarPubMed
Yeh, H.Chen, C.Fang, S.Chang, I.Wu, E.C.Lin, K.. Five-year trajectories of long-term benzodiazepine use by adolescents: patient, provider, and medication factors. Psychiatr Serv 2011;62(8):900–907.CrossRefGoogle ScholarPubMed
Cheng, J.Huang, W.Lin, K.Shih, Y.. Characteristics associated with benzodiazepine usage in elderly outpatients in Taiwan. Int J Geriatr Psychiatry 2008;23(6):618–624.CrossRefGoogle ScholarPubMed
Bocquier, A.Bezzou, K.Nauleau, S.Verger, P.. Dispensing of anxiolytics and hypnotics in southeastern France: demographic factors and determinants of geographic variations. Fundam Clin Pharmacol 2008;22(3):323–333.CrossRefGoogle ScholarPubMed
Victorri-Vigneau, C.Feuillet, F.Wainstein, L.Grall-Bronnec, M.Pivette, J.Chaslerie, A., et al.Pharmacoepidemiological characterisation of zolpidem and zopiclone usage. Eur J Clin Pharmacol 2013;69(11):1965–1972.CrossRefGoogle ScholarPubMed
Rat, C.Werner, E.L.Pivette, J.Senand, R.Nguyen, J.. Hypnotic prescription without face to face contact: a report from French family medicine. Eur J Gen Pract 2013;19(3):158–161.CrossRefGoogle ScholarPubMed
Simon, G.E.Vonkorff, M.Barlow, W.Pabiniak, C.Wagner, E.. Predictors of chronic benzodiazepine use in a health maintenance organization sample. J Clin Epidemiol 1996;49(9):1067–1073.CrossRefGoogle Scholar
Gray, S.L.Eggen, A.E.Blough, D.Buchner, D.LaCroix, A.Z.. Benzodiazepine use in older adults enrolled in a health maintenance organization. Am J GeriatrPsychiatry 2003;11(5):568–576.Google Scholar
Holm, E.Fosbol, E.Pedersen, H.Jensen, T.B.Nielsen, M.Weeke, P., et al.Benzodiazepine use in Denmark 1997–2008. Eur Geriatr Med 2012;3(5):299–303.CrossRefGoogle Scholar
Andersen, A.B.T.Frydenberg, M.. Long-term use of zopiclone, zolpidem and zaleplon among Danish elderly and the association with sociodemographic factors and use of other drugs. Pharmacoepidemiol Drug Saf 2011;20(4):378–385.CrossRefGoogle ScholarPubMed
Hoffmann, F.Pfannkuche, M.Glaeske, G.. High usage of zolpidem and zopiclone. Cross-sectional study using claims data. Nervenarzt 2008;79(1):67–72.CrossRefGoogle ScholarPubMed
Verthein, U.Martens, M.S.Raschke, P.Holzbach, R.. [Long-term prescription of benzodiazepines and non-benzodiazepines]. Gesundheitswesen 2013;75(7):430–437.Google Scholar
Kairuz, T.E.Truter, I.. A descriptive study of anxiolytic and hypnotic prescribing according to age and sex. Int J Pharm Pract 2007;15(4):301–306.CrossRefGoogle Scholar
Windle, A.Elliot, E.Duszynski, K.Moore, V.. Benzodiazepine prescribing in elderly Australian general practice patients. Aust N Z J Public Health 2007;31(4):379–381.CrossRefGoogle ScholarPubMed
Oh, S.Oh, K.S.Lee, K.Woo, J.Lee, B.Hwang, J.S., et al.In-depth investigation for prescribing trends of benzodiazepines in South Korea. Int J Clin Pharmacol Ther 2014;52(6):460–470.CrossRefGoogle ScholarPubMed
Nomura, K.Nakao, M.Sato, M.Yano, E.. The long-term prescription of benzodiazepines, psychotropic agents, to the elderly at a university hospital in Japan. Tohoku J Exp Med 2007;212(3):239–246.CrossRefGoogle Scholar
Isacson, D.. Long-term benzodiazepine use: Factors of importance and the development of individual use patterns over time – a 13-year follow-up in a Swedish community. Soc Sci Med 1997;44(12):1871–1880.CrossRefGoogle Scholar
Petitjean, S.Ladewig, D.Meier, C.R.Amrein, R.Wiesbeck, G.A.. Benzodiazepine prescribing to the Swiss adult population: results from a national survey of community pharmacies. Int Clin Psychopharmacol 2007;22(5):292–298.CrossRefGoogle ScholarPubMed
van Hulten, R.Isacson, D.Bakker, A.Leufkens, H.G.. Comparing patterns of long-term benzodiazepine use between a Dutch and a Swedish community. Pharmacoepidemiol Drug Saf 2003;12(1):49–53.CrossRefGoogle Scholar
Islam, M.M.Conigrave, K.M.Day, C.A.Nguyen, Y.Haber, P.S.. Twenty-year trends in benzodiazepine dispensing in the Australian population. Intern Med J 2014;44(1):57–64.CrossRefGoogle ScholarPubMed
Olfson, M.King, M.Schoenbaum, M.. Benzodiazepine use in the United States. JAMA Psychiatry 2015;72(2):136–142.CrossRefGoogle ScholarPubMed
World Health Organization. Rational use of benzodiazepines. Programme on substance abuse 1996, 96.11. 1996;p. 1–49.Google Scholar
Olmeda, N.G.Martínez, I.B.De la Poza, E.Consuelo, D.V.Tarazona, M.C.Modelling the consumption of anxiolytics and its addictive behaviour. Math Comput Model 2011;54(7–8):1626–1633.CrossRefGoogle Scholar
Placchi, M.Key considerations for long-term studies with anxiolytics. Eur Psychiatry 1996;11(3):144–148.CrossRefGoogle ScholarPubMed
Baldwin, D.S.Aitchison, K.Bateson, A.Curran, H.V.Davies, S.Leonard, B., et al.Benzodiazepines: risks and benefits. A reconsideration. J Psychopharmacol 2013;27(11):967–971.CrossRefGoogle ScholarPubMed
Logan, K.E.Lawrie, S.M.Long term use of hypnotics and anxiolytics. May not result in increased tolerance [27]. Br Med J 1994;309(6956):742.CrossRefGoogle Scholar
Kruse, W.H.Problems and pitfalls in the use of benzodiazepines in the elderly. Drug Saf 1990;5(5):328–344.CrossRefGoogle ScholarPubMed
Gérardin, M.Victorri-Vigneau, C.Guerlais, M.Guillou-Landreat, M.Grall-Bronnec, M.Jolliet, P.Benzodiazepines consumption: does dependence vary with age?. Subst Use Misuse 2014;49(11):1417–1425.CrossRefGoogle ScholarPubMed
Bradley, M.C.Motterlini, N.Padmanabhan, S.Cahir, C.Williams, T.Fahey, T., et al.Potentially inappropriate prescribing among older people in the United Kingdom. BMC Geriatr 2014;14(1).CrossRefGoogle ScholarPubMed
Leikola, S.Dimitrow, M.Lyles, A.Pitkälä, K.Airaksinen, M.Potentially inappropriate medication use among finnish non- institutionalized people aged = 65 years: a register-based, cross-sectional, national study. Drugs Aging 2011;28(3):227–236.CrossRefGoogle ScholarPubMed
Porritt, K.Gomersall, J.Lockwood, C.JBI's systematic reviews: study selection and critical appraisal. Am J Nurs 2014;114(6):47–52.CrossRefGoogle ScholarPubMed
von Elm, E.Altman, D.G.Egger, M.Pocock, S.J.Gøtzsche, P.C.Vandenbroucke, J.P.The strengthening and the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies. J Clin Epidemiol 2008;61(4):344–349.CrossRefGoogle ScholarPubMed
Tiihonen, J.Suokas, J.T.Suvisaari, J.M.Haukka, J.Korhonen, P.Polypharmacy with antipsychotics, antidepressants, or benzodiazepines and mortality in schizophrenia. Arch Gen Psychiatry 2012;69(5):476–483.CrossRefGoogle ScholarPubMed
Starcevic, V.Benzodiazepines for anxiety disorders: maximising the benefits and minimising the risks. Adv Psychiatr Treat 2012;18(4):250–258.CrossRefGoogle Scholar
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