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Metabolic profiles in adults with autism spectrum disorder and intellectual disabilities

Published online by Cambridge University Press:  15 April 2020

L. Moses ,
N. Katz  and
A. Weizman
L. Moses*
Affiliation:
Health Services, Division for Intellectual and Developmental Disabilities, Ministry of Social Affairs and Social Services, Jerusalem, Israel Maccabi Health Services, South District, Israel
N. Katz
Affiliation:
Geha Mental Health Center, Petah Tikva and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
A. Weizman
Affiliation:
Geha Mental Health Center, Petah Tikva and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel Laboratory of Biological Psychiatry, Felsenstein Medical Research Center, Sackler Faculty of Medicine, Tel Aviv University, Petah Tikva, Israel
*
*Corresponding author. Moshav Nir-Hen 4, 79330, Israel. Tel.: +972 52 3774206; fax: +972 153 8 6848854. E-mail address: lilachmoses@yahoo.com (L. Moses).
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Abstract

Introduction

Low levels of blood cholesterol have been found in some children with autism spectrum disorders (ASD). Psychotropic medications, commonly used by people with ASD and people with intellectual disabilities (ID) are frequently associated with altered metabolic profiles.

Purpose

We aimed to compare metabolic features of adults with ASD or ID with those of a community-based population.

Subjects and methods

Data on blood fasting glucose (FBG), lipid profile, liver enzyme profile, TSH, BMI, medications and diagnoses of 80 adults with ASD, 77 adults with ID and 828 control adults were drawn from medical charts/database. Candidates that used glucose or lipid lowering medications were not included.

Results

Total-cholesterol levels of people with ASD and ID were significantly lower than those of the controls (168.3 ± 32.78, 168.2 ± 32.91, 185.4 ± 40.49 mg/dL, respectively, P < 0.001) but after adjusting for gender, age and BMI and using Bonferroni correction, the significance was lost. Compared to controls, ASD and ID had significantly lower FBG (by –14.45 ± 1.81, –14.58 ± 1.54 mg/dl, respectively; P < 0.001 for both) and liver enzymes, despite using psychotropic medications.

Discussion and conclusion

In contrast to other psychiatric patients receiving similar medications, people with ASD and ID have unaltered lipid profiles and lower glucose and liver enzyme levels compared to a community-based population.

Keywords

AutismIntellectual disabilitiesCholesterolGlucoseMetabolic profile
Type
Original article
Information
European Psychiatry , Volume 29 , Issue 7 , September 2014 , pp. 397 - 401
Copyright
Copyright © 2013 Elsevier Masson SAS

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Footnotes

1

Equal contribution.

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