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Neurochemical and behavioral sensitization to d-amphetamine in healthy subjects measured with [11C]-(+)-PHNO-PET

Published online by Cambridge University Press:  23 March 2020

A. Popovic ,
M. Bauer ,
L. Bartova ,
U. Sauerzopf ,
N. Praschak-Rieder ,
C. Rami-Mark ,
L. Nics ,
C. Philippe ,
M. Mitterhauser  and
W. Wadsak
...Show all authors
A. Popovic*
Affiliation:
Medical University of Vienna, Department of Psychiatry and Psychotherapy, Vienna, Austria
M. Bauer
Affiliation:
Medical University of Vienna, Department of Clinical Pharmacology, Vienna, Austria
L. Bartova
Affiliation:
Medical University of Vienna, Department of Psychiatry and Psychotherapy, Vienna, Austria
U. Sauerzopf
Affiliation:
Medical University of Vienna, Department of Psychiatry and Psychotherapy, Vienna, Austria
N. Praschak-Rieder
Affiliation:
Medical University of Vienna, Department of Psychiatry and Psychotherapy, Vienna, Austria
C. Rami-Mark
Affiliation:
Medical University of Vienna, Department of Nuclear Medicine, Vienna, Austria
L. Nics
Affiliation:
Medical University of Vienna, Department of Nuclear Medicine, Vienna, Austria
C. Philippe
Affiliation:
Medical University of Vienna, Department of Nuclear Medicine, Vienna, Austria
M. Mitterhauser
Affiliation:
Medical University of Vienna, Department of Nuclear Medicine, Vienna, Austria
W. Wadsak
Affiliation:
Medical University of Vienna, Department of Nuclear Medicine, Vienna, Austria
S. Kasper
Affiliation:
Medical University of Vienna, Department of Psychiatry and Psychotherapy, Vienna, Austria
M. Willeit
Affiliation:
Medical University of Vienna, Department of Psychiatry and Psychotherapy, Vienna, Austria
*
* Corresponding author.

Abstract

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Introduction

It has been shown that patients with schizophrenia are super-sensitive towards dopamine-releasing agents such as amphetamine. Here, we studied the effects of amphetamine sensitization on amphetamine-induced dopamine release in healthy subjects.

Objectives

To measure d-amphetamine-induced dopamine release as measured with the D2,3 agonist radioligand [11C]-(+)-PHNO-PET via change in non-displacable binding potential (BPND) and behavioral measures of d-amphetamine effects with drug effects questionnaire (DEQ) and subjective states questionnaire (SSQ).

Aims

To study d-amphetamine-induced sensitization in healthy subjects on a behavioral and neurochemical level with [11C]-(+)-PHNO-PET in order to gain more knowledge on sensitization-induced changes in the dopaminergic system.

Methods

Twelve stimulant-naïve healthy male subjects underwent three 90-min [11C]-(+)-PHNO-PET-scans and four oral administrations of d-amphetamine. After a naïve baseline scan, subjects underwent a PET scan with previous ingestion of 0.4 mg/kg bodyweight of d-amphetamine 90–120 minutes before scanning. Subsequently, subjects were sensitized to d-amphetamine with the same dose on two separate days. Thereafter, they underwent another PET scan with previous d-amphetamine ingestion. DEQ and SSQ were administered before, 60 min, 90–120 min, and 210 min after amphetamine ingestion.

Results

We found significant sensitization effects on a behavioral level and on a neurochemical level after four administrations of amphetamine. Items of the SSQ, which showed significant sensitization effects were “outgoing”, “energetic”, “lively”, “alert” and “focused”.

Conclusions

We were able to induce significant behavioral and neurochemical sensitization in healthy humans, which were measured with [11C]-(+)-PHNO-PET for the first time. This sensitization model will be useful for studying the neurobiology of schizophrenia.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Type
FC86
Information
European Psychiatry , Volume 33 , Issue S1: Abstracts of the 24th European Congress of Psychiatry , March 2016 , pp. S105 - S106
Copyright
Copyright © European Psychiatric Association 2016
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