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Neurocognitive Functioning of Adolescents with Clinical High Risk for Psychosis, other Psychiatric Symptoms, and Psychosis

Published online by Cambridge University Press:  01 September 2022

M. Orlandi ,
M. Iorio ,
C. Rogantini ,
A. Vecchio ,
C. Coci ,
E. Casini ,
R. Borgatti  and
M. Mensi
M. Orlandi
Affiliation:
Fondazione Mondino - Istituto Neurologico Nazionale IRCCS, Child Neuropsychiatry, Pavia, Italy
M. Iorio
Affiliation:
University of Pavia, Department Of Brain And Behavioural Sciences, Pavia, Italy
C. Rogantini
Affiliation:
University of Pavia, Department Of Brain And Behavioural Sciences, Pavia, Italy
A. Vecchio
Affiliation:
Fondazione Mondino - Istituto Neurologico Nazionale IRCCS, Child Neuropsychiatry, Pavia, Italy
C. Coci*
Affiliation:
University of Pavia, Department Of Brain And Behavioural Sciences, Pavia, Italy
E. Casini
Affiliation:
Fondazione Mondino - Istituto Neurologico Nazionale IRCCS, Child Neuropsychiatry, Pavia, Italy
R. Borgatti
Affiliation:
Fondazione Mondino - Istituto Neurologico Nazionale IRCCS, Child Neuropsychiatry, Pavia, Italy University of Pavia, Department Of Brain And Behavioural Sciences, Pavia, Italy
M. Mensi
Affiliation:
Fondazione Mondino - Istituto Neurologico Nazionale IRCCS, Child Neuropsychiatry, Pavia, Italy University of Pavia, Department Of Brain And Behavioural Sciences, Pavia, Italy
*
*Corresponding author.

Abstract

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Introduction

Clinical High Risk of Psychosis (CHR-P) condition and the clinical validity of at-risk criteria are still little studied in child and adolescent population.

Objectives

This study aimed to discover neurocognitive profiles of adolescents with CHR-P, compared with adolescents with psychosis and youth with other psychiatric symptoms that do not meet CHR-P criteria.

Methods

We divided 116 adolescents (12-18 years old) in three groups according to the semi-structured interview Comprehensive Assessment of At-Risk Mental States (CAARMS): psychosis, attenuated psychosis syndrome (APS), non-APS. Moreover, we administered Wechsler scales to assess the IQ, Wisconsin Card Sorting Test to assess abstract reasoning and flexibility, Rey-Osterrieth complex figure to assess planning and attention, and Trail Making Test to assess psychomotor speed, visual attention and task switching. We administered BVN 12-18 subtests to assess lexical denomination, verbal and nonverbal working memory, selective auditory, visual attention, phonemic and categorial fluency, reasoning and problem solving.

Results

Nineteen adolescents met criteria for psychosis, 47 for APS, and 50 did not meet criteria neither for psychosis nor for APS. APS group performed better than psychosis group and similar to non-APS group in processing speed, planning, visual attention, and categorial fluency. APS did not show a significant difference from the other groups in working memory and backward digit span, showing an intermediate profile; non-APS and psychosis groups still differed significantly in these functions.

Conclusions

Identifying typical neurocognitive profiles leads to more accurate diagnoses and early intervention that can lead to better patient outcomes.

Disclosure

The authors declare that they do not have a significant financial interest, consultancy or other relationship with products, manufacturer(s) of products or providers of services related to this abstrac.

Keywords

schizophrénianeurocognitive profilesPSYCHOTIC DISORDERSAdolescents
Type
Abstract
Information
European Psychiatry , Volume 65 , Special Issue S1: Abstracts of the 30th European Congress of Psychiatry , June 2022 , pp. S322
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of the European Psychiatric Association
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