Hostname: page-component-cd9895bd7-hc48f Total loading time: 0 Render date: 2024-12-25T19:11:28.542Z Has data issue: false hasContentIssue false
  • English
  • Français

Neuronal correlates of appetite regulation in patients with schizophrenia: Is there a basis for future appetite dysfunction?

Published online by Cambridge University Press:  15 April 2020

O. Lungu ,
K. Anselmo ,
G. Letourneau ,
A. Mendrek ,
B. Stip ,
O. Lipp ,
P. Lalonde ,
L. Ait Bentaleb  and
E. Stip
O. Lungu
Affiliation:
Departement de psychiatrie, Université de Montréal, Montréal, Québec, Canada C.H.U.M and Centre de recherche de l'institut universitaire de gériatrie de Montréal, Montréal, Québec, Canada
K. Anselmo
Affiliation:
Departement de psychiatrie, Université de Montréal, Montréal, Québec, Canada Centre de recherche Fernand-Seguin, affilié à l'université de Montréal, 7401 Hochelaga, H1N 3V2, Montréal, Québec, Canada
G. Letourneau
Affiliation:
Departement de psychiatrie, Université de Montréal, Montréal, Québec, Canada Centre de recherche Fernand-Seguin, affilié à l'université de Montréal, 7401 Hochelaga, H1N 3V2, Montréal, Québec, Canada
A. Mendrek
Affiliation:
Departement de psychiatrie, Université de Montréal, Montréal, Québec, Canada Centre de recherche Fernand-Seguin, affilié à l'université de Montréal, 7401 Hochelaga, H1N 3V2, Montréal, Québec, Canada
B. Stip
Affiliation:
École polytechnique de Montréal, Montréal, Québec, Canada
O. Lipp
Affiliation:
Departement de psychiatrie, Université de Montréal, Montréal, Québec, Canada Centre de recherche Fernand-Seguin, affilié à l'université de Montréal, 7401 Hochelaga, H1N 3V2, Montréal, Québec, Canada
P. Lalonde
Affiliation:
Departement de psychiatrie, Université de Montréal, Montréal, Québec, Canada Centre de recherche Fernand-Seguin, affilié à l'université de Montréal, 7401 Hochelaga, H1N 3V2, Montréal, Québec, Canada
L. Ait Bentaleb
Affiliation:
Departement de psychiatrie, Université de Montréal, Montréal, Québec, Canada Centre de recherche Fernand-Seguin, affilié à l'université de Montréal, 7401 Hochelaga, H1N 3V2, Montréal, Québec, Canada
E. Stip*
Affiliation:
Departement de psychiatrie, Université de Montréal, Montréal, Québec, Canada Centre de recherche Fernand-Seguin, affilié à l'université de Montréal, 7401 Hochelaga, H1N 3V2, Montréal, Québec, Canada
*
⁎Corresponding author. E-mail address:emmanuel.stip@umontreal.ca (E. Stip).
Get access

Abstract:

Background

Given the undesired metabolic side effects of atypical antipsychotic medication it is important to understand the neuronal basis related to processing of appetite regulation in patients affected by schizophrenia.

Methods:

Here we used functional magnetic resonance imaging (fMRI) to assess brain activity in response to food cues and neutral stimuli in twenty patients with schizophrenia and eleven healthy individuals. In addition to clinical and dietary habits assessments, we collected, in patients, measurements of fasting glucose, ghrelin, leptin, insulin, prolactin and lipids blood concentration and we correlated the cerebral activity with clinical and metabolic measures.

Results:

Both groups engaged a common neuronal network while processing food cues, which included the left insula, primary sensorimotor areas, and inferior temporal and parietal cortices. Cerebral responses to appetitive stimuli in thalamus, parahippocampus and middle frontal gyri were specific only to schizophrenic patients, with parahippocampal activity related to hunger state and increasing linearly over time. Antipsychotic medication dosage correlated positively with a cognitive measure reflecting food cravings, whereas the severity of the disease correlated negatively with a cognitive measure indicating dietary restraint in eating habits. These cognitive variables correlated, in turn, with parahippocampal and thalamic neuronal activities, respectively.

Conclusions:

We identified a specific neural substrate underlying cognitive processing of appetitive stimuli in schizophrenia, which may contribute to appetite dysfunction via perturbations in processing of homeostatic signals in relation to external stimuli. Our results also suggest that both antipsychotic medication and the disease severity per se could amplify these effects, via different mechanisms and neuronal networks.

Keywords

Schizophrenia and psychosisfMRIBinge eating disorderAntipsychotics
Type
Original article
Information
European Psychiatry , Volume 28 , Issue 5 , June 2013 , pp. 293 - 301
Copyright
Copyright © European Psychiatric Association

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Addington, D, Addington, J, Schissel, BSchizophr Res. 1990;3(4):247–251.CrossRefGoogle Scholar
Anselmo, K, Stip, E, Mancini-Marie, A, Mendrek, A, Ait Bentaleb, L, Lipp, O, et al.Schizophr Res. 2008;98(February, Supplement):22.CrossRefGoogle Scholar
Bleuer, ETextbook of psychiatry (published originally in 1911). New York: Maximilian Co.; 1924.Google Scholar
Bruch, HEating disorders and schizophrenia. Usdin, G.L.Bruch, H.Psychoneurosis and Schizophrenia.. Philadelphia: J.B. Lippincott; 1966. p. 113–124.Google Scholar
Cheng, Y, Meltzoff, AN, Decety, JCereb Cortex. 2007;17(8):1979–1986.CrossRefGoogle Scholar
Cohen, D, Farley, TAPrev Chronic Dis. 2008;5(1):A23.Google Scholar
Coletta, M, Platek, S, Mohamed, FB, van Steenburgh, JJ, Green, D, Lowe, MRJ Abnormal Psychol. 2009;118(3):598–609.CrossRefGoogle Scholar
Cornier, MA, Von Kaenel, SS, Bessesen, DH, Tregellas, JRAm J Clin Nutr. 2007;86(4):965–971.CrossRefGoogle Scholar
Del Parigi, A, Gautier, JF, Chen, K, Salbe, AD, Ravussin, E, Reiman, E, et al.Ann N Y Acad Sci. 2002;967:389–397.CrossRefGoogle Scholar
Fagerstrom, KO, Schneider, NGJ Behav Med. 1989;12(2):159–182.CrossRefGoogle Scholar
Hennekens, CHJ Clin Psychiatr. 2007;68(Suppl 4):4–7.CrossRefGoogle Scholar
Kay, SR, Fiszbein, A, Opler, LASchizophr Bull. 1987;13(2):261–276.CrossRefGoogle Scholar
Kaye, WH, Bailer, UF, Frank, GK, Wagner, A, Henry, SEPhysiol Behav. 2005;86(1–2):15–17.CrossRefGoogle Scholar
Kaye, WH, Frank, GK, Bailer, UF, Henry, SE, Meltzer, CC, Price, JC, et al.Physiol Behav. 2005;85(1):73–81.CrossRefGoogle Scholar
Kretschmer, EPhysique and Character An Investigation of the Nature of Constitution and of the Theory of Temperament. New York: Harcourt, Brace & Co; 1925.Google Scholar
Lang, PJ, Öhman, A, Vaitl, D.The International Affective Picture System (photographic slides). Gainesville: Center for Research in Psychophysiology, University of Florida; 1988.Google Scholar
Lieberman, MD, Cunningham, WASoc Cogn Affect Neurosci. 2009;4(4):423–428.CrossRefGoogle Scholar
Liu, YR, Loh, EW, Lan, TH, Chen, SF, Yu, YH, Chang, YH, et al.Pharmacogenomics J. 2010;10(1):30–39.CrossRefGoogle Scholar
Meyer, JMJ Clinical Psychopharmacol. 2001;21(4):369–374.CrossRefGoogle Scholar
Newcomer, JWJ Clin Psychiatr. 2007;68(Suppl 1):20–27.Google Scholar
Penny, WD, Holmes, AJ.Random-Effects Analysis. In: Frackowiak, RSJ, Friston, KJ, Frith, C, Dolan, R, Friston, KJ, Price, CJ, et al., eds. Human Brain Function. 2nd. ed. London: Academic Press 2003.Google Scholar
Rummel-Kluge, C, Komossa, K, Schwarz, S, Hunger, H, Schmid, F, Lobos, CA, et al.Schizophrenia Res. 2010.Google Scholar
Santel, S, Baving, L, Krauel, K, Munte, TF, Rotte, MBrain Res. 2006;1114(1):138–148.CrossRefGoogle Scholar
Sengupta, SM, Klink, R, Stip, E, Baptista, T, Malla, A, Joober, RSchizophr Res. 2005;80(1):131–133.CrossRefGoogle Scholar
Sentissi, O, Viala, A, Bourdel, MC, Kaminski, F, Bellisle, F, Olie, JP, et al.Int Clin Psychopharmacol 2009;24(5):257–264.CrossRefGoogle Scholar
Stunkard, AJ, Messick, SJ Psychosom Res. 1985;29(1):71–83.CrossRefGoogle Scholar
Talairach, J, Tournoux, P.Thieme Medical Publishers, New York. 1988.Google Scholar
Tataranni, PA, Gautier, JF, Chen, K, Uecker, A, Bandy, D, Salbe, AD, et al.Proceedings of the National Academy of Sciences of the United States of America. 1999;96(8):4569–4574.CrossRefGoogle Scholar
Tiwari, AK, Zai, CC, Likhodi, O, Lisker, A, Singh, D, Souza, RP, et al.Neuropsychopharmacology. 2010;35(6):1315–1324.CrossRefGoogle Scholar
Uher, R, Murphy, T, Brammer, MJ, Dalgleish, T, Phillips, ML, Ng, VW, et al.Am J Psychiatr. 2004;161(7):1238–1246.CrossRefGoogle Scholar
Van den Eynde, F, Claudino, AM, Mogg, A, Horrell, L, Stahl, D, Ribeiro, W, et al.Biol Psychiatry. 2011;67(8):793–795.CrossRefGoogle Scholar
van Kuyck, K, Gerard, N, Van Laere, K, Casteels, C, Pieters, G, Gabriels, L, et al.J Psychiatr Res. 2009;43(14):1133–1145.CrossRefGoogle Scholar
Wagner, A, Aizenstein, H, Mazurkewicz, L, Fudge, J, Frank, GK, Putnam, K, et al.Neuropsychopharmacology. 2008;33(3):513–523.CrossRefGoogle Scholar
Submit a response

Comments

No Comments have been published for this article.