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Neurophysiological correlates of negative symptom domains in patients with schizophrenia

Published online by Cambridge University Press:  23 March 2020

A. Vignapiano ,
V. Montefusco ,
G.M. Plescia ,
G. Di Lorenzo ,
C. Niolu ,
M. Altamura ,
D. Marasco ,
G.M. Giordano ,
A. Mucci  and
S. Galderisi
A. Vignapiano*
Affiliation:
University of Naples SUN, Psychiatry, Naples, Italy
V. Montefusco
Affiliation:
University of Naples SUN, Psychiatry, Naples, Italy
G.M. Plescia
Affiliation:
University of Naples SUN, Psychiatry, Naples, Italy
G. Di Lorenzo
Affiliation:
University of Rome “Tor Vergata”, Department of Systems Medicine, Rome, Italy
C. Niolu
Affiliation:
University of Rome “Tor Vergata”, Department of Systems Medicine, Rome, Italy
M. Altamura
Affiliation:
University of Foggia, Department of Clinical and Experimental Medicine- Psychiatry Unit, Foggia, Italy
D. Marasco
Affiliation:
University of Foggia, Department of Clinical and Experimental Medicine- Psychiatry Unit, Foggia, Italy
G.M. Giordano
Affiliation:
University of Naples SUN, Psychiatry, Naples, Italy
A. Mucci
Affiliation:
University of Naples SUN, Psychiatry, Naples, Italy
S. Galderisi
Affiliation:
University of Naples SUN, Psychiatry, Naples, Italy
*
*Corresponding author.

Abstract

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Introduction

Negative symptoms have long been recognized as a central feature of schizophrenia, which limit recovery, having a strong negative impact on real-life functioning. External validators of the negative symptoms domains might help refining hypotheses on their pathophysiological basis.

Aims

The objective of this study was to evaluate, in the context of the multicenter study of the Italian Network for Research on Psychoses, the relationships between auditory event-related potentials (ERPs) components and negative symptom domains in patients with schizophrenia (SCZ).

Methods

We examined ERPs recorded during an auditory odd-ball task in 115 chronic stabilized SCZ (78% on second-generation antipsychotics) and 62 matched healthy controls (HC). Negative symptoms were assessed using the Brief Negative Symptom Scale.

Results

Our main findings included significant N100 and P3b amplitude reductions in SCZ compared to HC. P3b amplitude did not correlate with any negative symptom domain, while N100 amplitude correlated with both anhedonia and avolition domains.

Conclusions

Avolition and anhedonia, often clustering in the same factor, are related to abnormalities of early components of the ERPs correlated with perceptual and automatic attention processes. None of the negative symptom domains is associated with abnormalities of the later stages indexed by P3 amplitude.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Type
EW569
Information
European Psychiatry , Volume 33 , Issue S1: Abstracts of the 24th European Congress of Psychiatry , March 2016 , pp. s265
Copyright
Copyright © European Psychiatric Association 2014
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