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No association between polymorphisms in three genes of cytochrome p450 family and paranoid schizophrenia in northern Chinese Han population

Published online by Cambridge University Press:  16 April 2020

Yanbin Jia ,
Xin Yu ,
Boyu Zhang ,
Yanbo Yuan ,
Qi Xu ,
Yucun Shen  and
Yan Shen
Yanbin Jia
Affiliation:
National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), 5, Dong Dan San Tiao, Beijing100005, China
Xin Yu
Affiliation:
Peking University Institute of Mental Health, Beijing100083, China
Boyu Zhang
Affiliation:
National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), 5, Dong Dan San Tiao, Beijing100005, China
Yanbo Yuan
Affiliation:
Peking University Institute of Mental Health, Beijing100083, China
Qi Xu
Affiliation:
National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), 5, Dong Dan San Tiao, Beijing100005, China
Yucun Shen
Affiliation:
Peking University Institute of Mental Health, Beijing100083, China
Yan Shen*
Affiliation:
National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), 5, Dong Dan San Tiao, Beijing100005, China
*
*Corresponding author. Email address: sheny@ms.imicams.ac.cn (Y. Shen).
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Abstract

We genotyped six SNPs in the genes of p450 family among paranoid schizophrenics and normal controls. All subjects are unrelated Han Chinese. Three showed polymorphic, and no significant differences in allele or genotype frequencies were detected between patients and controls. Thus we obtained no evidence for the involvement of the polymorphisms in paranoid schizophrenia in the population investigated.

Keywords

SchizophreniaAssociation studySNPCytochrome p450
Type
Short communication
Information
European Psychiatry , Volume 19 , Issue 6 , September 2004 , pp. 374 - 376
Copyright
Copyright © 2004 European Psychiatric Association

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