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Not the same old madness: Evaluating the clinical profile of the “schizophrenia spectrum” disorders

Published online by Cambridge University Press:  23 March 2020

A. Russo ,
N. Verdolini ,
G. Menculini ,
P. Moretti ,
R. Quartesan  and
A. Tortorella
A. Russo
Affiliation:
Division of Psychiatry, Clinical Psychology and Rehabilitation, Department of Medicine, Santa Maria Della Misericordia Hospital, University of Perugia, Perugia, Italy
N. Verdolini
Affiliation:
Division of Psychiatry, Clinical Psychology and Rehabilitation, Department of Medicine, Santa Maria Della Misericordia Hospital, University of Perugia, Perugia, Italy Bipolar Disorders Unit, Institute of Neuroscience, IDIBAPS CIBERSAM, Hospital Clínic, Barcelona, Spain
G. Menculini
Affiliation:
Division of Psychiatry, Clinical Psychology and Rehabilitation, Department of Medicine, Santa Maria Della Misericordia Hospital, University of Perugia, Perugia, Italy
P. Moretti
Affiliation:
Division of Psychiatry, Clinical Psychology and Rehabilitation, Department of Medicine, Santa Maria Della Misericordia Hospital, University of Perugia, Perugia, Italy
R. Quartesan
Affiliation:
Division of Psychiatry, Clinical Psychology and Rehabilitation, Department of Medicine, Santa Maria Della Misericordia Hospital, University of Perugia, Perugia, Italy
A. Tortorella
Affiliation:
Division of Psychiatry, Clinical Psychology and Rehabilitation, Department of Medicine, Santa Maria Della Misericordia Hospital, University of Perugia, Perugia, Italy

Abstract

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Introduction

The “schizophrenia spectrum” concept allowed better identifying the psychopathology underpinning disorders including schizophrenia, schizoaffective disorder (SZA) and cluster A personality disorders (PD).

Aims

To compare the clinical portrait of the schizophrenia spectrum disorders, focusing on the impact of the affective dimension.

Methods

Inpatients at the acute psychiatric ward of Perugia (Umbria-Italy) were evaluated with the structured clinical interview for DSM-IV Axis I and Axis II disorders and diagnosed with a “schizophrenia spectrum” disorder according to DSM-IV-TR. The clinical evaluation was conducted using the positive and negative syndrome scale (PANSS). Pearson correlations of the different subscales in the three groups and between the negative scales with the affective symptom “depression” were conducted.

Results

The sample consisted of 72 inpatients (schizophrenia 55.6%, SZA 20% and cluster A PD 19.4%). The negative and the general psychopathology scales directly correlated at different degrees in the three groups (schizophrenia: r = 0.750; P < 0.001; SZA: r = 0.625, P = 0.006; cluster A PD: r = 0.541, P = 0.046). The symptom “depression” directly correlated with 5 out of 7 negative symptoms: blunted affect (r = 0.616, P < 0.001), emotional withdrawal (r = 0.643, P < 0.001), poor rapport (r = 0.389, P = 0.001), passive/apathetic social withdrawal (r = 0.538, P < 0.001), lack of spontaneity & flow of conversation (r = 0.399, P = 0.001).

Conclusions

Our study confirmed the existence of the “schizophrenia spectrum” with combined different disorders lying on a continuum in which negative symptoms mainly correlated with the psychopathological functioning. Noteworthy, the symptoms of the negative scale strongly correlated with the “depression” symptom, underlying the impact of the affective symptoms on the severity of the “schizophrenia spectrum” disorders.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Type
e-Poster Viewing: Schizophrenia and other psychotic disorders
Information
European Psychiatry , Volume 41 , Issue S1: Abstract of the 25th European Congress of Psychiatry , April 2017 , pp. s833 - s834
Copyright
Copyright © European Psychiatric Association 2017
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