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Orexins in the clinical course of bipolar disorder

Published online by Cambridge University Press:  13 August 2021

C. Moya-Lacasa ,
M. Valtueña-García ,
E. Martín Gil ,
L. González-Blanco  and
M.P. García-Portilla
C. Moya-Lacasa*
Affiliation:
Psychiatry, SESPA Mental Health Services of Principado de Asturias, OVIEDO, Spain Department Of Psychiatry, University of Oviedo, Oviedo, Spain
M. Valtueña-García
Affiliation:
Department Of Psychiatry, University of Oviedo, Oviedo, Spain
E. Martín Gil
Affiliation:
Psychiatry, SESPA Mental Health Services of Principado de Asturias, OVIEDO, Spain
L. González-Blanco
Affiliation:
Psychiatry, SESPA Mental Health Services of Principado de Asturias, OVIEDO, Spain Department Of Psychiatry, University of Oviedo, Oviedo, Spain Neuroscience And Sense Organs, ISPA HEALTH RESEARCH INSTITUTE OF THE PRINCIPALITY OF ASTURIAS, Oviedo, Spain Psychiatry, CIBERSAM, Madrid, Spain
M.P. García-Portilla
Affiliation:
Psychiatry, SESPA Mental Health Services of Principado de Asturias, OVIEDO, Spain Department Of Psychiatry, University of Oviedo, Oviedo, Spain Neuroscience And Sense Organs, ISPA HEALTH RESEARCH INSTITUTE OF THE PRINCIPALITY OF ASTURIAS, Oviedo, Spain Psychiatry, CIBERSAM, Madrid, Spain
*
*Corresponding author.

Abstract

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Introduction

Orexins are involved in the regulation of circadian rhythms which play an important role in mood regulation(1,2), and are hypothesised to be associated with major depressive disorder(3). However, scarce studies analyse their relationship with bipolar disorder (BD).

Objectives

To evaluate the relationship of orexin-A and the clinical course of BD

Methods

95 BD patients were tested for serum orexin-A. The clinical course was analysed through number of depressive, manic/mixed episodes. HDRS and YMRS were used to assess severity of current episode. Statistics: Spearman correlations, U Mann-Whitney, linear regression analysis.

Results

Mean age was 50.03 (SD=12.87) and 64.2% were women. 63.2% had BD-type I. Mean number of manic, depressive and mixed episodes was 2.32 (SD=3.07), 7.28 (SD=12.37), and 3.01 (SD=9.06), respectively. Mean age of onset was 26.09 (SD=10.50). Mean concentration of orexin-A was 21.78 pg/ml (SD=15.41), with no differences in sex, body mass index, age at onset or presence of insomnia(ICD-10). A correlation with age was observed; r=0.24 (p=0.019). No association was identified between orexin-A and severity of current episode. In relation to clinical course, no correlation was found with manic or mixed episodes. However, a negative correlation was identified between orexin-A levels and number of depressive episodes; r=-0.36 (p=0.001). When linear regression (orexin-A as dependent variable) was used to control for age, only this covariate (B=0.304) entered in the model (R2=0.067, F=6.045, p=0.015).

Conclusions

No relationship between orexin-A and number of manic/mixed episodes were detected. The association of orexin-A with number of depressive episodes dissappeared when age was controlled.

Disclosure

No significant relationships.

Keywords

bipolar disorderDepressionorexins
Type
Abstract
Information
European Psychiatry , Volume 64 , Special Issue S1: Abstracts of the 29th European Congress of Psychiatry , April 2021 , pp. S623
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of the European Psychiatric Association
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