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Physical capacity, respiratory quotient and energy expenditure during exercise in male patients with schizophrenia compared with healthy controls

Published online by Cambridge University Press:  15 April 2020

B.M. Nilsson ,
R.M. Olsson ,
A. Öman ,
F.-A. Wiesel ,
L. Ekselius  and
A.H. Forslund
B.M. Nilsson*
Affiliation:
Department of Neuroscience, Psychiatry, Uppsala University, Uppsala University Hospital, 75185Uppsala, Sweden
R.M. Olsson
Affiliation:
Department of Neuroscience, Psychiatry, Uppsala University, Uppsala University Hospital, 75185Uppsala, Sweden
A. Öman
Affiliation:
Department of Neuroscience, Psychiatry, Uppsala University, Uppsala University Hospital, 75185Uppsala, Sweden
F.-A. Wiesel
Affiliation:
Department of Neuroscience, Psychiatry, Uppsala University, Uppsala University Hospital, 75185Uppsala, Sweden
L. Ekselius
Affiliation:
Department of Neuroscience, Psychiatry, Uppsala University, Uppsala University Hospital, 75185Uppsala, Sweden
A.H. Forslund
Affiliation:
Department of Neuroscience, Psychiatry, Uppsala University, Uppsala University Hospital, 75185Uppsala, Sweden
*
*Corresponding author. Tel.: +46 70 6110669; fax: +46 18 154157. E-mail addresses: bjorn.nilsson@neuro.uu.se, bjorn.nilsson@akademiska.se (B.M. Nilsson).
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Abstract

Background

Despite massive research on weight gain and metabolic complications in schizophrenia there are few studies on energy expenditure and no current data on physical capacity.

Aim

To determine oxygen uptake capacity, respiratory quotient (RQ) and energy expenditure during a submaximal exercise test in patients with schizophrenia and healthy controls.

Method

Ten male patients and 10 controls were included. RQ and energy expenditure were investigated with indirect calorimetry during a cycle ergometer test. The submaximal work level was defined by heart rate and perceived exhaustion. Physical capacity was determined from predicted maximal oxygen uptake capacity (VO2-max).

Results

The patients exhibited significantly higher RQ on submaximal workloads and lower physical capacity. A significant lower calculated VO2-max remained after correction for body weight and fat free mass (FFM). Energy expenditure did not differ on fixed workloads.

Conclusion

RQ was rapidly increasing in the patients during exercise indicating a faster transition to carbohydrate oxidation and anaerobic metabolism that also implies a performance closer to maximal oxygen uptake even at submaximal loads. This may restrict the capacity for everyday activity and exercise and thus contribute to the risk for weight gain. Physical capacity was consequently significantly lower in the patients.

Keywords

SchizophreniaPhysical capacityRespiratory quotientOxygen uptake capacityEnergy expenditureBody weight
Type
Original articles
Information
European Psychiatry , Volume 27 , Issue 3 , April 2012 , pp. 206 - 212
Copyright
Copyright © Elsevier Masson SAS 2012

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Footnotes

1†

Frits-Axel Wiesel (1944–2007).

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