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Physical training for patients with depression and anxiety - a randomized controlled study

Published online by Cambridge University Press:  13 August 2021

Q. Zhai ,
Y. Freund-Levi ,
A. Horn ,
A.-C. Fridenberger ,
E. Lager ,
S. Montgomery  and
J. Persson
Q. Zhai*
Affiliation:
School Of Medical Sciences, Örebro University, Örebro, Sweden Psychiatry, Örebro University Hospital, Örebro, Sweden
Y. Freund-Levi
Affiliation:
Psychiatry, Örebro University Hospital, Örebro, Sweden Department Of Neurology, Care Sciences And Society, Karolinska Institutet, Stockholm, Sweden
A. Horn
Affiliation:
Psychiatry, Örebro University Hospital, Örebro, Sweden
A.-C. Fridenberger
Affiliation:
Psychiatry, Örebro University Hospital, Örebro, Sweden
E. Lager
Affiliation:
Psychiatry, Örebro University Hospital, Örebro, Sweden
S. Montgomery
Affiliation:
School Of Medical Sciences, Örebro University, Örebro, Sweden
J. Persson
Affiliation:
School Of Law, Psychology And Social Work, Örebro University, Örebro, Sweden
*
*Corresponding author.

Abstract

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Introduction

Pharmaceutical treatment and psychotherapy constitute the most common treatment methods for depression and anxiety. Physical training has been shown to have comparable effect to cognitive behavioral therapy in treatment of mild to moderate depression and anxiety. Physically active individuals also show lower risks to develop depression and relapse in depression.

Objectives

The objectives are to evaluate how physical activity can affect depressive and anxiety symptoms, by examining biomarkers in the blood and from the gut and also by measuring cognitive functions. Hopefully, this can lead to new treatment strategies for patients with depression and anxiety.

Methods

102 patients are randomized to two groups and undergo 12 weeks intervention as add-on to standard outpatient psychiatric treatment. The first group will participate in physical training three times per week and the other group will receive relaxation therapy on a weekly basis. Daily activity intensity will be measured before and at the last week of intervention with an accelerometer. Blood and faeces sample collection, symptom grading by clinician together with self-rating scales and cognitive screening will be performed at baseline, week 12 and one year of follow-up. The cognitive screenings are performed digitally in cooperation with Mindmore.

Results

The RCT is currently recruiting patients at the Department of Psychiatry of Örebro University Hospital.

Conclusions

The project aims to be holistic in its approach, combining the defining clinical psychiatric symptoms in patients who have both depression and anxiety with the finding and evaluation of new biomarkers from blood and gut to improve cognitive functions.

Disclosure

No significant relationships.

Keywords

DepressionAnxietyExercisecognitive functions
Type
Abstract
Information
European Psychiatry , Volume 64 , Special Issue S1: Abstracts of the 29th European Congress of Psychiatry , April 2021 , pp. S690
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of the European Psychiatric Association
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