Hostname: page-component-78c5997874-8bhkd Total loading time: 0 Render date: 2024-11-10T12:34:04.807Z Has data issue: false hasContentIssue false
  • English
  • Français

Platelet serotonin-binding and dexamethasone suppression test in melancholia and dysthymia

Published online by Cambridge University Press:  16 April 2020

C Gastó ,
J Vallejo ,
JM Menchón ,
R Catalán ,
A Otero ,
M Jesus Martínez de Osaba  and
F Ribera
C Gastó
Affiliation:
Department of Psychiatry and Medical Psychobiology, University of Barcelona, Barcelona Subdivision of Psychiatry and Psychology, Hospital Clinic i Provincial, Barcelona
J Vallejo
Affiliation:
Hospital de Bellvitge, Barcelona and Department of Psychiatry and Medical Psychobiology, University of Barcelona, Barcelona
JM Menchón
Affiliation:
Department of Psychiatry and Medical Psychobiology, University of Barcelona, Barcelona
R Catalán
Affiliation:
Subdivision of Psychiatry and Psychology, Hospital Clinic i Provincial, Barcelona
A Otero
Affiliation:
Department of Psychiatry and Medical Psychobiology, University of Barcelona, Barcelona Subdivision of Psychiatry and Psychology, Hospital Clinic i Provincial, Barcelona
M Jesus Martínez de Osaba
Affiliation:
Hormonal Laboratory, Hospital Clinic, Barcelona, Spain
F Ribera
Affiliation:
Hormonal Laboratory, Hospital Clinic, Barcelona, Spain
Get access

Summary

Platelet serotonin-binding (Bmax), using tritiated-seroionin as the ligand, was determined in 75 patients suffering from major depression with melancholia and in 26 patients diagnosed from dysthymic disorder. Twenty-five normal subjects were used as a control group. The melancholic group had significantly lower Bmax values (mean: 6.7 ± 6.1 pmol/108 platelets) than either dysthymic (9.3 ± 3.9 pmol/108 platelets) or control (9.2 ± 4.8 pmol/108 platelets) groups, while there were no significant differences between the two latter groups. There was also a significant difference on postdexamethasone Cortisol between melancholic (6.3 ± 7.1 μg/dL) and dysthymic (1.4 ± 1.4 μg/dL) groups, with a higher rate of nonsuppressors in melancholic groups. Although both tests were abnormal in the melancholic group, no relationship was found between platelet serotonin-binding and the dexaniethasone suppression test.

Keywords

platelet serotonin-bindingdexamethasone suppressionmelancholiadysthymia
Type
Original article
Information
European Psychiatry , Volume 9 , Issue 6 , 1994 , pp. 281 - 287
Copyright
Copyright © European Psychiatric Association 1994

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Andreasen, NCEndicott, JSpitzer, RLWinokur, GThe family history method using diagnostic criteria Arch Gen Psychiatry 1977;34: 1229–35CrossRefGoogle ScholarPubMed
Berrios, GEBulbena, AThe Hamilton Depression Scale and the numerical description of symptoms of depressionIn: Bech, PCoppen, A eds. The Hamilton Scales Springer Verlag Berlin Heidelberg: 1990; 80–92CrossRefGoogle Scholar
Biegon, AWeizman, AKarp, LRam, ATiano, SWolff, MSerotonin 5-HT2 receptor binding on blood platelets -a peripheral marker for depression? Life Sci 1987;41:2485-92CrossRefGoogle Scholar
Carroll, BJFeinberg, MGreden, Jet al. A specific laboratory test for the diagnosis of melancholia: standardization, validation, and clinical utility Arch Gen Psychiatry 1981;38: 15–22CrossRefGoogle Scholar
Cheung, AHall, TRHarvey, SSerotoninergic regulation of corticosterone secretion in domestic fowl J Endocrinol 1986;113: 159-65CrossRefGoogle Scholar
Chicz-Demet, AReist, CDemet, EMRelationship between seasonal patterns of platelet serotonin uptake and 3H-imipramine binding in depressed patients and normal controls Prog Neuro-Psychopharmacol & Biol Psychiatry 1991;15: 25–39CrossRefGoogle ScholarPubMed
Cowen, PJCharig, EMEraser, SElliot, JMPlatelet 5-HT receptor binding during depressive illness and tricyclic antidepressant treatment J Affective Disord 1987;13: 45–50CrossRefGoogle ScholarPubMed
Dam, HDexamethasone suppression test Acta Psychiatr Scand 1988;78 (suppl 345):38–44CrossRefGoogle Scholar
Dumhrille-Ross, AWa Tang, SAbsence of high affinity (3imipramine binding in platelets and cerebral cortex of fawn hooded rats Eur J Pharmacol 1981;72: 137-8CrossRefGoogle Scholar
Ellis, PMMcIntosh, CMBeeston, RSalmond, CECooke, RRMellsop, GPlatelet tritiated imipramine binding in psychiatric patients: relationship to symptoms and severity of depression Acta Psychiatr Scand 1990;82: 275-82CrossRefGoogle ScholarPubMed
Fuller, RWSerotonergic stimulation of pituitary-adrenocortical function in rats Neuroendocrlnology 1981;32:118-27CrossRefGoogle ScholarPubMed
Gastó, CVallejo, JMartinez de Osaba, MJOriola, JRivera, FFixation de la 3H-5HT par les plaquettes humaines: application à la depression Ann Med Psychol 1988;146: 89–91Google Scholar
Hamilton, MA rating scale for depression J Neurol Ncurosurg Psychiatry 1960;23: 56–62CrossRefGoogle Scholar
Jhanwar-Uniyal, MRenner, KBallo, MLuine, VNLeibowitz, SFSerotonin and 5-hydroxyindoleacetic acid levels in discrete hypothalamic areas of the rat brain: relation to circulating corticosterone Neurosci Lett 1987;79: 145-50CrossRefGoogle ScholarPubMed
Langer, SZSchoemaker, HPlatelet imipramine binding in depressionIn: Sen, AAKLee, T eds. Receptors and Ligands in Psychiatry Cambridge: Cambridge University Press, 1988:327-46Google Scholar
Lewis, DAMcChesney, CTritialed imipramine binding distinguishes among subtypes of depression Arch Gen Psychiatry 1985;42: 485-8CrossRefGoogle ScholarPubMed
Lingjaerde, OBlood platelets as a model system for studying the biochemistry of depressionIn: Usdin, EAsberg, MBertilsson, LSjoqvist, P eds. Frontiers in Biochemical and Pharmacological Research in Depression New York: Raven Press, 1984:99–111Google Scholar
Lowenthal, MHaven, CInteraction and adaptation: intimacy as a critical variable An Soc Rev 1986;33: 20–30CrossRefGoogle Scholar
Medalie, JGoldbourt, VAngina pectoris among 10,000 men. II. Psychosocial and other risk factors as evidenced by a multivariate analysis of a five-year incidence study Am J Med 1976;60: 910-21CrossRefGoogle ScholarPubMed
Mellerup, ETPlenge, PImipramine binding in depression and other psychiatric conditions Acta Psychiatr Scand 1988:78 (suppl 345):61-8CrossRefGoogle Scholar
Mellerup, ETPlenge, PWhy some depressed patients may have low platelet 3H-imipramine binding Acta Psychiatr Scand 1990;82: 330-4CrossRefGoogle ScholarPubMed
Meltzer, HYArora, RCBaber, RTricou, BJSerotonin uptake in blood platelets of psychiatric patients Arch Gen Psychiatry 1981;38: 1322-6CrossRefGoogle ScholarPubMed
Menchon, JMVallejo, JGastó, CCatalan, RBulbena, ADexamethasone suppression test and platelet serotonin binding in melancholia and neurotic depression: are they related? Biol Psychiatry 1991;29 (11s):342Google Scholar
Nankai, MYoshimoto, SNarila, KTakahashi, RPlatelet 3H-imipramine binding in depressed patients and its circadian variations in healthy controls J Affective Disord 1986; 11:207-12CrossRefGoogle ScholarPubMed
Oriola, JMartinez de Osaba, MJGastó, CVallejo, JRibera, FMéthode d'étude des récepteurs de la sérotonine des plaquettes humaines et application à des patientes dépressives Ann Biol Clin 1985;43:618Google Scholar
Pandey, GNPandey, SCJanicak, PGMarks, RCDavis, JMPlatelet serotonin-2 receptor binding sites in depression and suicide Biol Psychiatry 1990;28: 215-22CrossRefGoogle ScholarPubMed
Paul, SMRehavi, MSkolnick, PBallenger, JCGoodwin, FKDepressed patients have decreased binding of tritiated imipramine to platelet serotonin transporter Arch Gen Psychiatry 1981;38: 1315-7CrossRefGoogle ScholarPubMed
Pletscher, ALaubscher, AGraf, MSaner, ABlood platelets as models for central 5-hydroxytryptaminergic neurons Ann Biol Clin 1979;37: 35-9Google ScholarPubMed
Sarason, IAssessing the impact life changes: development of the Life Experiences Survey J Consult Clin Psychol 1978;46: 926-46CrossRefGoogle ScholarPubMed
Schick, PMcKlan, LSerotonin binding in human platelets Biochem Pharmacol 1979;28: 2667-70CrossRefGoogle ScholarPubMed
Stahl, SMThe human platelet. A diagnostic and research tool for the study of biogenic amines in psychiatric and neurologic disorders Arch Gen Psychiatry 1977;34: 509-16CrossRefGoogle Scholar
Stokes, PEMaas, JWDavis, JMKoslow, SIHCasper, RCStoll, PMBiogenic amine and metabolite levels in depressed patients with high versus normal hypothalamic-pituitary-adrenocortical activity Am J Psychiatry 1987; 144:868-72Google ScholarPubMed
Tobeña, ASanchez, XMasana, JMartinez de Osaba, MJPlatelet serotonin binding and plasma Cortisol in panic disorder before attd after alprazolam plus behavioral guidance treatment Eur Psychiatry 1991;6: 31-7Google Scholar
Tuomisto, JTukiainen, EDecreased uptake of 5-hydroxitriptamine in blood platelets from depressed patients Nature 1976;262: 596-8CrossRefGoogle ScholarPubMed
Vallejo, JGastó, CCatalan, RSalamero, MDouble-blind study of imipramine versus phenelzine in melancholias and dysthymic disorders Br J Psychiat 1987;151: 639-42CrossRefGoogle ScholarPubMed
Van Praag, MMKahn, RSAsnis, GMWetzler, SBrown, SLBleich, AKorn, MLDenosologization of biological psychiatry or the specificity of 5HT disturbances in psychiatric disorders J Affective Disord 1987;13: 1–8CrossRefGoogle ScholarPubMed
Submit a response

Comments

No Comments have been published for this article.