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Prediction of psychosis in clinical high-risk patients by the Schizotypal Personality Questionnaire. Results of the EPOS project

Published online by Cambridge University Press:  15 April 2020

R.K.R. Salokangas ,
P. Dingemans ,
M. Heinimaa ,
T. Svirskis ,
S. Luutonen ,
J. Hietala ,
S. Ruhrmann ,
G. Juckel ,
H. Graf von Reventlow  and
D. Linszen
...Show all authors
R.K.R. Salokangas*
Affiliation:
Department of Psychiatry, University of Turku, Turku, Finland Psychiatric Clinic, Turku University Central Hospital, Turku, Finlandst Turku Psychiatric Clinic, Turku Mental Health Centre, Turku, Finland
P. Dingemans
Affiliation:
Academic Medical Centre, University of Amsterdam, Amsterdam, Netherlands Mediant, Enschede, Netherlands
M. Heinimaa
Affiliation:
Department of Psychiatry, University of Turku, Turku, Finland
T. Svirskis
Affiliation:
Department of Psychiatry, University of Helsinki, Helsinki, Finland Peijas Hospital, Helsinki University Central Hospital, Helsinki, Finland
S. Luutonen
Affiliation:
Department of Psychiatry, University of Turku, Turku, Finland Psychiatric Clinic, Turku University Central Hospital, Turku, Finlandst
J. Hietala
Affiliation:
Department of Psychiatry, University of Turku, Turku, Finland Psychiatric Clinic, Turku University Central Hospital, Turku, Finlandst Turku Psychiatric Clinic, Turku Mental Health Centre, Turku, Finland
S. Ruhrmann
Affiliation:
Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany
G. Juckel
Affiliation:
Department of Psychiatry, Ruhr-University Bochum, LWL University Hospital, Bochum, Germany
H. Graf von Reventlow
Affiliation:
Department of Psychiatry, Ruhr-University Bochum, LWL University Hospital, Bochum, Germany
D. Linszen
Affiliation:
Academic Medical Centre, University of Amsterdam, Amsterdam, Netherlands Department of Psychiatry and Psychology, University of Maastricht, Maastricht, Netherlands
M. Birchwood
Affiliation:
School of Psychology, University of Birmingham, Birmingham, United Kingdom
P. Patterson
Affiliation:
Youthspace–Birmingham and Solihull Mental Health Foundation Trust, Birmingham, United Kingdom
F. Schultze-Lutter
Affiliation:
University Hospital of Child and Adolescent Psychiatry, University of Bern, Bern, Switzerland
J. Klosterkötter
Affiliation:
Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany
*
*Corresponding author. FIN-20520 Turku, Finland. Tel.: +358 2 3131 740; fax: +358 2 3132 730. E-mail address:Raimo.K.R.Salokangas@tyks.fi (R.K.R. Salokangas).
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Abstract

Objective

Schizotypal features indicate proneness to psychosis in the general population. It is also possible that they increase transition to psychosis (TTP) among clinical high-risk patients (CHR). Our aim was to investigate whether schizotypal features predict TTP in CHR patients.

Methods

In the EPOS (European Prediction of Psychosis Study) project, 245 young help-seeking CHR patients were prospectively followed for 18 months and their TTP was identified. At baseline, subjects were assessed with the Schizotypal Personality Questionnaire (SPQ). Associations between SPQ items and its subscales with the TTP were analysed in Cox regression analysis.

Results

The SPQ subscales and items describing ideas of reference and lack of close interpersonal relationships were found to correlate significantly with TTP. The co-occurrence of these features doubled the risk of TTP.

Conclusions

Presence of ideas of reference and lack of close interpersonal relations increase the risk of full-blown psychosis among CHR patients. This co-occurrence makes the risk of psychosis very high.

Keywords

Schizotypal featuresClinical high-risk patientsTransition to psychosis
Type
Original article
Information
European Psychiatry , Volume 28 , Issue 8 , October 2013 , pp. 469 - 475
Copyright
Copyright © 2013 Elsevier Masson SAS

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