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Predictors of real-life functioning in subjects with schizophrenia: A 4-year follow-up study

Published online by Cambridge University Press:  13 August 2021

S. Galderisi ,
A. Mucci ,
D. Gibertoni ,
A. Rossi ,
P. Rocca ,
A. Bertolino  and
M. Maj
S. Galderisi*
Affiliation:
Department Of Psychiatry, University of Campania “Luigi Vanvitelli”, NAPOLI, Italy
A. Mucci
Affiliation:
Department Of Psychiatry, Univeristy of Campania Luigi Vanvitelli, Naples, Italy
D. Gibertoni
Affiliation:
Department Of Biomedical And Neuromotor Sciences, University of Bologna, Bologna, Italy
A. Rossi
Affiliation:
Department Of Biotechnological And Applied Clinical Sciences, Section Of Psychiatry, University of L’Aquila, L’Aquila, Italy
P. Rocca
Affiliation:
Department Of Neuroscience, University of Turin, Torino, Italy
A. Bertolino
Affiliation:
Department Of Neurological And Psychiatric Sciences, University of Bari, Bari, Italy
M. Maj
Affiliation:
Department Of Psychiatry, University of Campania L. Vanvitelli, Naples, Naples, Italy
*
*Corresponding Author.

Abstract

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In a cross-sectional study, the Italian Network for Research on Psychoses (INReP) found that variables relevant to the disease, personal resources and social context explain 53.8% of real-life functioning variance in a large sample of community dwelling people with schizophrenia. In a longitudinal study, the INReP aimed to identify baseline predictors of main domains of real-life functioning, i.e. work skills, interpersonal relationships and everyday life skills, at 4-year follow-up. We assessed psychopathology, social and non-social cognition, functional capacity, personal resources, and context-related factors, as well as real-life functioning as the main outcome. We used structural equation modeling (SEM) and latent change score (LCS) model to identify predictors of real-life functioning domains at follow-up and changes from baseline in the same domains. Six-hundred-eighteen subjects took part in the study. Neurocognition predicted everyday life and work skills; avolition predicted interpersonal relationships; positive symptoms work skills, and social cognition work skills and interpersonal functioning. Higher neurocognitive abilities predicted the improvement of everyday life and work skills, as well as of social cognition and functional capacity; better baseline social cognition predicted the improvement of work skills and interpersonal functioning, and better baseline everyday life skills predicted the improvement of work skills. Several variables which predict important aspects of functional outcome of people with schizophrenia are not routinely assessed and are not systematically targeted by intervention programs in community mental health services. A larger dissemination of practices such as cognitive training and personalized psychosocial interventions should be promoted in mental health care.

Disclosure

No significant relationships.

Keywords

psychopathologyneurocognitionsocial cognitionFunctional Outcome
Type
Abstract
Information
European Psychiatry , Volume 64 , Special Issue S1: Abstracts of the 29th European Congress of Psychiatry , April 2021 , pp. S40
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of the European Psychiatric Association
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