Hostname: page-component-cd9895bd7-dzt6s Total loading time: 0 Render date: 2024-12-25T19:05:21.373Z Has data issue: false hasContentIssue false
  • English
  • Français

Prefrontal cognitive deficits in patients with schizophrenia treated with atypical or conventional antipsychotics

Published online by Cambridge University Press:  16 April 2020

U. Müller ,
K. Werheid ,
E. Hammerstein ,
S. Jungmann  and
T. Becker
U. Müller*
Affiliation:
Department of Psychiatry, University of Leipzig, Leipzig, Germany Departments of Psychiatry and Experimental Psychology, University of Cambridge, Downing Site, Cambridge CB2 3EB, UK
K. Werheid
Affiliation:
Department of Cognitive Neurology, University of Leipzig, Leipzig, Germany Department of Psychology, Humboldt University Berlin, Berlin, Germany
E. Hammerstein
Affiliation:
Department of Psychiatry, University of Leipzig, Leipzig, Germany
S. Jungmann
Affiliation:
Department of Psychiatry, University of Leipzig, Leipzig, Germany
T. Becker
Affiliation:
Department of Psychiatry, University of Leipzig, Leipzig, Germany Department of Psychiatry II, University of Ulm, Günzburg, Germany
*
*Corresponding author. E-mail address: um207@cam.ac.uk
Get access

Abstract

Forty-three patients with schizophrenia were investigated with a short neurocognitive screening battery focussing on working memory and executive functions. As compared to healthy controls, patients showed impairments in the modified card sorting test, in verbal fluency and all span tasks with exception of digit span forward. Patients who were treated with atypicals showed better performance in the digit ordering test (manipulation task) when compared to a group of patients who received conventional antipsychotics; this difference was not due to disease severity, age or education. Manipulation tasks might be useful for neurocognitive follow-up and intervention studies.

Keywords

Antipsychotic agentsExecutive functionsDigit ordering testSchizophreniaWorking memory
Type
Short communication
Information
European Psychiatry , Volume 20 , Issue 1 , January 2005 , pp. 70 - 73
Copyright
Copyright © Elsevier SAS 2005

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Addington, J, Addington, DNeurocognitive and social functioning in schizophrenia: a 2.5 year follow-up study. Schizophr Res 2000;44:47–56.CrossRefGoogle ScholarPubMed
Cooper, JA, Sagar, HJ, Doherty, SM, Jordan, N, Tidswell, P, Sullivan, EVDifferent effects of dopaminergic and anticholinergic therapies on cognitive and motor function in Parkinson’s disease: a follow-up study of untreated patients. Brai 1992;115:1701–1725.CrossRefGoogle ScholarPubMed
Hamann, J, Pfeiffer, H, Leucht, S, Kissling, WAre patients with schizophrenia under-treated with second-generation antipsychotics? A pilot study of the prescription practices of German psychiatrists. Pharmacopsychiatr 2003;36:309–312.Google ScholarPubMed
Harvey, PD, Green, MF, Keefe, RS, Velligan, DICognitive functioning in schizophrenia: a consensus statement on its role in the definition and evaluation of effective treatments for the illness. J Clin Psychiatr 2004;65:361–372.CrossRefGoogle ScholarPubMed
Honey, RA, Turner, DC, Honey, GD, Sharar, SR, Kumaran, D, Pomarol-Clotet, Eet al.Subdissociative dose ketamine produces a deficit in manipulation but not maintenance of the contents of working memory. Neuropsychopharmacolog 2003;28:2037–2044.CrossRefGoogle Scholar
Kapur, SHow antipsychotics become anti-‘psychotic’—from dopamine to salience to psychosis. Trends Pharmacol Sci 2004;25:402–406.CrossRefGoogle ScholarPubMed
Kim, J, Glahn, DC, Nuechterlein, KH, Cannon, TDMaintenance and manipulation of information in schizophrenia: further evidence for impairment in the central executive component of working memory. Schizophr Res 2004;68:173–187.CrossRefGoogle ScholarPubMed
Mishara, AL, Goldberg, TEA meta-analysis and critical review of the effects of conventional neuroleptic treatment on cognition in schizophrenia: opening a closed book. Biol Psychiatr 2004;55:1013–1022.CrossRefGoogle ScholarPubMed
Möller, HJManagement of the negative symptoms of schizophrenia: new treatment options. CNS Drug 2003;17:793–823.CrossRefGoogle ScholarPubMed
Moritz, S, Andresen, B, Jacobsen, D, Mersmann, K, Wilke, U, Lambert, Met al.Neuropsychological correlates of schizophrenic syndromes in patients treated with atypical neuroleptics. Eur Psychiatr 2001;16:354–361.CrossRefGoogle ScholarPubMed
Müller, U, Wächter, T, Barthel, H, Reuter, M, Von Cramon, DYStriatal [123I]β-CIT SPECT and prefrontal memory functions in Parkinson’s disease. J Neural Transm 2000;107:303–319.Google ScholarPubMed
Robbins, TWChemical neuromodulation of frontal-executive functions in humans and other animals. Exp Brain Res 2000;133:130–138.CrossRefGoogle ScholarPubMed
Weickert, TW, Goldberg, TE, Marenco, S, Bigelow, LB, Egan, MF, Weinberger, DRComparison of cognitive performances during a placebo period and an atypical antipsychotic treatment period in schizophrenia: critical examination of confounds. Neuropsychopharmacolog 2003;28:1491–1500.CrossRefGoogle Scholar
Weiss, EM, Bilder, RM, Fleischhacker, WWThe effects of second-generation antipsychotics on cognitive functioning and psychosocial outcome in schizophrenia. Psychopharmacolog 2002;162:11–17.CrossRefGoogle Scholar
Werheid, K, Hoppe, C, Thöne, A, Müller, U, Müngersdorf, M, Von Cramon, DYThe adaptive digit ordering test: clinical application, reliability and validity of a verbal working memory test. Arch Clin Neuropsycho 2002;17:547–565.CrossRefGoogle ScholarPubMed
World Health Organisation (WHO) The ICD-10 classification of mental and behavioural disorders: diagnostic criteria for researc Geneva: WHO; 1992.Google Scholar
Submit a response

Comments

No Comments have been published for this article.