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Pruritic urticarial papules and plaques of gestation in perinatal depression

Published online by Cambridge University Press:  23 March 2020

F. Hassan ,
M. Azaaibi ,
S. Shahid ,
T.S. Saimwala ,
N. Kalar ,
M.T. Mughal ,
A. Wahab ,
G. Wahab ,
F. Haider  and
A. Azam
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F. Hassan*
Affiliation:
Department of Psychiatry, Karachi Medical and Dental College, Abbasi Shaheed Hospital, Karachi, Pakistan
M. Azaaibi
Affiliation:
Department of Dermatology Mafraq Hospital, Abu Dhabi, United Arab Emirates
S. Shahid
Affiliation:
Department of Psychiatry, Karachi Medical and Dental College, Abbasi Shaheed Hospital, Karachi, Pakistan
T.S. Saimwala
Affiliation:
Department of Dermatology, Karachi Medical and Dental College, Abbasi Shaheed Hospital, Karachi, Pakistan
N. Kalar
Affiliation:
Department of Obstetrics and Gynecology, Singleton Hospital, South Wales, Sketty Swansea, UK
M.T. Mughal
Affiliation:
Department of Psychiatry, Dow University of Health Sciences, Karachi, Pakistan
A. Wahab
Affiliation:
Department of Medicine, Karachi Medical and Dental College, Abbasi Shaheed Hospital, Karachi, Pakistan
G. Wahab
Affiliation:
Qureshi Clinic of Family Medicine, Karachi, Pakistan
F. Haider
Affiliation:
Department of Medicine, Karachi Medical and Dental College, Karachi, Pakistan
A. Azam
Affiliation:
Department of Gynaecology and Obstetrics, Abbasi Shaheed Hospital, Karachi, Pakistan
N. Shahid
Affiliation:
Department of Medicine, Abbasi Shaheed Hospital, Karachi, Pakistan
E. Mujeeb
Affiliation:
Department of Community Health Sciences, Karachi Medical and Dental College, Karachi, Pakistan
M.U. Kalar
Affiliation:
Qureshi Clinic of Family Medicine, Karachi, Pakistan
*
* Corresponding author.

Abstract

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Introduction

The cutaneous polymorphic eruption of pregnancy (PEP) is presented by skin lesions usually in the third trimester of gestation and about 13% of women also suffer from perinatal depression.

Objective

To determine the frequency of pruritic urticarial papules of gestation with and without perinatal depression.

Aim

To assess the maternal causes for polymorphic eruption of pregnancy (PEP) in patients with and without perinatal depression.

Methods

Cases and controls were matched on the grounds of maternal weight gain in gestation, hormonal changes, deficit in iron and zinc, dysregulation of hypothalamic pituitary axis, pre-maturity, pre-eclampsia, pre-term labour. Univariate and multivariate analysis, adjusting for important demographic factors and comorbodities was conducted to assess the relationship of PEP with and without perinatal depression in reduced and full models of ANOVA in regression analysis. (Reduced model Y = β0 + β1X1 + … and the full model Y = β0 + β1X1 + β2X2 + β3X3 + β4X4 + β5X5 + β6X6 + …)

Results

Polymorphic eruption of pregnancy with perinatal depression was statistically significant in maternal weight gain in gestation [odds ratio (OR) 1.20; 95% (CI): 1.15–1.30], hormonal changes [(OR) 2.78; 95% (CI): 2.52–2.82], deficit in iron and zinc [(OR) 2.18; 95% (CI): 2.04–2.38], dysregulation of hypothalamic pituitary axis [(OR) 1.37; 95% (CI): 1.18–1.49] and was not statistically significant in pre-maturity, pre-eclampsia and pre-term labour in cases and controls.

Conclusion

Pruritic urticarial papules and plaques of gestation are commonly associated in patients with perinatal derpession.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Type
EW99
Information
European Psychiatry , Volume 33 , Issue S1: Abstracts of the 24th European Congress of Psychiatry , March 2016 , pp. S136
Copyright
Copyright © European Psychiatric Association 2016
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