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Psychosis-proneness correlates with expression levels of dopaminergic genes

Published online by Cambridge University Press:  15 April 2020

P. Grant ,
F. Gabriel ,
Y. Kuepper ,
C. Wielpuetz  and
J. Hennig
P. Grant*
Affiliation:
Center for Psychobiology and Behavioral Medicine, Justus-Liebig-University Giessen, Otto-Behaghel-Str. 10F, 35394Giessen, Germany
F. Gabriel
Affiliation:
Center for Psychobiology and Behavioral Medicine, Justus-Liebig-University Giessen, Otto-Behaghel-Str. 10F, 35394Giessen, Germany
Y. Kuepper
Affiliation:
Center for Psychobiology and Behavioral Medicine, Justus-Liebig-University Giessen, Otto-Behaghel-Str. 10F, 35394Giessen, Germany
C. Wielpuetz
Affiliation:
Center for Psychobiology and Behavioral Medicine, Justus-Liebig-University Giessen, Otto-Behaghel-Str. 10F, 35394Giessen, Germany
J. Hennig
Affiliation:
Center for Psychobiology and Behavioral Medicine, Justus-Liebig-University Giessen, Otto-Behaghel-Str. 10F, 35394Giessen, Germany
*
*Corresponding author. Tel.: +496419926155; fax: +496419926159. E-mail address:phillip.grant@psychol.uni-giessen.de (P. Grant).
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Abstract

Psychosis-proneness or schizotypy is a personality organisation mirroring individual risk for schizophrenia-development. Believed to be a fully dimensional construct sharing considerable geno- and phenotypal variance with clinical schizophrenia, it has become an increasingly promising tool for basic psychosis-research. Although many studies show genetic commonalities between schizotypy and schizophrenia, changes in regulation of gene expression have never been examined in schizotypy before. We therefore extracted RNA from the blood, a valid surrogate for brain tissue, of a large sample of 67 healthy male volunteers and correlated the activities of all genes relevant for dopaminergic neurotransmission with the positive schizotypy-scale of the O-LIFE. We found significant negative correlations regarding the expression of the genes COMT, MAOB, DRD4, DRD5 and FOS, indicating that increased schizotypy coincides with higher levels of dopaminergic dysregulation on the mRNA-level. Considering the advantages of this method, we suggest that it be applied more often in fundamental psychosis-research.

Keywords

Schizophrenia and psychosisMolecular biologyPsychosis pronenessSchizotypyGene expressionEndophenotype
Type
Short Communications
Information
European Psychiatry , Volume 29 , Issue 5 , June 2014 , pp. 304 - 306
Copyright
Copyright © Elsevier Masson SAS 2014

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Footnotes

☆

These data were, in part, presented at the 2013-meeting of the International Society for the Study of Individual Differences.

References

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