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Quantitative detection of methylated SOCS-1 in schizophrenia and bipolar disorder considering SOCS-1 -1478 CA/del polymorphism and clinical parameters

Published online by Cambridge University Press:  01 September 2022

H.M. Aytac ,
S. Pehlivan ,
M. Pehlivan  and
Y. Oyaci
H.M. Aytac*
Affiliation:
Basaksehir Cam and Sakura City Hospital, Department Of Psychiatry, Istanbul, Turkey
S. Pehlivan
Affiliation:
Istanbul Faculty of Medicine, Istanbul University, Department Of Medical Biology, Istanbul, Turkey
M. Pehlivan
Affiliation:
Gaziantep University, Department Of Hematology, Gaziantep, Turkey
Y. Oyaci
Affiliation:
Istanbul Faculty of Medicine, Istanbul University, Department Of Medical Biology, Istanbul, Turkey
*
*Corresponding author.

Abstract

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Introduction

Suppressor of cytokine signaling (SOCS) proteins are the critical negative regulators of immune responses that exert their effects by inhibiting the Jak/Stat signaling pathway.

Objectives

To investigate quantitative detection of methylated SOCS-1 in schizophrenia and bipolar disorder considering SOCS-1 -1478CA/del polymorphism and clinical parameters.

Methods

114 patients with SCZ, 86 patients with BD, and 80 healthy volunteers were included in the case-control study. The patients were consecutively admitted to the outpatient clinic for three months and were evaluated with some scales for clinical parameters. To measure the methylation level of the SOCS-1 gene, bisulfite-converted DNA samples were analyzed using the real-time quantitative methylation-specific PCR method. SOCS-1 -1478CA/del gene polymorphism was evaluated by using the PCR-RFLP.

Results

The SOCS-1 promoter methylation levels of SCZ (p = .001) and BD (p = .024) were found to be significantly different from the control group. SOCS-1 methylation was significantly different between SCZ groups due to the age of onset (p = .009). Again, SOCS-1 methylation was significantly different between BD groups due to YMRS scale scores (p = .027). While the SOCS-1 genotype distributions of SCZ patients were not found to be statistically different from the control group, a significant difference in genotype distribution between BD patients and healthy controls was found (p = .013).

Conclusions

The methylated SOCS-1 quantity in DNA samples of both SCZ and BD patients was significantly lower than in control samples. Whereas the SOCS-1 -1478CA/del polymorphism was not related to SCZ, it may be associated with the BD.

Disclosure

No significant relationships.

Keywords

bipolar disorderschizophréniaSOCS-1promoter methylation
Type
Abstract
Information
European Psychiatry , Volume 65 , Special Issue S1: Abstracts of the 30th European Congress of Psychiatry , June 2022 , pp. S120 - S121
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of the European Psychiatric Association
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