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Radiation-associated cerebroophtalmic effects

Published online by Cambridge University Press:  01 September 2022

K. Loganovsky ,
P. Fedirko ,
D. Marazziti ,
T. Loganovskaja ,
K. Kuts ,
I. Perchuk ,
T. Babenko ,
K. Antypchuk  and
G. Kreinis
K. Loganovsky*
Affiliation:
State Institution “National Research Centre for Radiation Medicine of National Academy of Medical Sciences of Ukraine”, Radiation Psychoneurology, Institute Of Clinical Radiology, Kyiv, Ukraine
P. Fedirko
Affiliation:
State Institution “National Research Centre for Radiation Medicine of National Academy of Medical Sciences of Ukraine”, Institute Of Radiation Hygiene And Epidemiology, Kyiv, Ukraine
D. Marazziti
Affiliation:
University of Pisa, Clinical And Experimental Medicine, Section Of Psychiatry, Pisa, Italy
T. Loganovskaja
Affiliation:
State Institution “National Research Centre for Radiation Medicine of National Academy of Medical Sciences of Ukraine”, Radiation Psychoneurology, Institute Of Clinical Radiology, Kyiv, Ukraine
K. Kuts
Affiliation:
State Institution “National Research Centre for Radiation Medicine of National Academy of Medical Sciences of Ukraine”, Radiation Psychoneurology, Institute Of Clinical Radiology, Kyiv, Ukraine
I. Perchuk
Affiliation:
State Institution “National Research Centre for Radiation Medicine of National Academy of Medical Sciences of Ukraine”, Radiation Psychoneurology, Institute Of Clinical Radiology, Kyiv, Ukraine
T. Babenko
Affiliation:
State Institution “National Research Centre for Radiation Medicine of National Academy of Medical Sciences of Ukraine”, Institute Of Radiation Hygiene And Epidemiology, Kyiv, Ukraine
K. Antypchuk
Affiliation:
State Institution “National Research Centre for Radiation Medicine of National Academy of Medical Sciences of Ukraine”, Radiation Psychoneurology, Institute Of Clinical Radiology, Kyiv, Ukraine
G. Kreinis
Affiliation:
State Institution “National Research Centre for Radiation Medicine of National Academy of Medical Sciences of Ukraine”, Radiation Psychoneurology, Institute Of Clinical Radiology, Kyiv, Ukraine
*
*Corresponding author.

Abstract

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Introduction

We proposed to consider the brain and eye as a target of ionizing radiation exposure. Prevention of potential radiation-associated cerebroophtalmic effects are crucial for successful long-term space missions; interventional radiology; medical, occupational and accidental irradiation

Objectives

Determination of radiation-associated cerebroophtalmic effects in the long term after irradiation in adulthood and in utero.

Methods

Neuropsychiatric, ophtalmological, neurophysiological and neuropsychological assessment of irradiated in adulthood (57 Chernobyl accident clean-up workers, liquidators), 52 persons exposed in utero as a result of the Chernobyl accident, comparison group (51 combatants of the Antiterrorist operation in Donbass), and 53 healthy people.

Results

Radiation-associated cerebroophthalmic pathology is characterized by high neuropsychiatric and ophthalmic comorbidity, which increases in proportion to the radiation dose, and is mainly represented by chronic vascular and degenerative diseases of the brain and retina, mild cognitive impairment (after irradiation in adulthood), as well as disorders of the autonomic nervous system; non-psychotic organic mental disorders; neurotic, stress-related and somatoform disorders; vascular and dystrophic processes in the retina (after in utero exposure). Characteristic of both radiological scenarios remains intellectual disharmony due to a decrease in the verbal IQ. The delay and attenuation of cerebral visual afferentation processing were observed in prenatally exposed.

Conclusions

Radiation-associated cerebroophtalmic effects in the long term after irradiation in adulthood and in utero could be mainly classified as a “small vessel disease of the brain and eye” of vascular-degenerative nature and possible latent demyelination after irradiation in utero.

Disclosure

No significant relationships.

Keywords

Chernobyl accidentcomorbidityIonizing radiationcerebroophtalmic effects
Type
Abstract
Information
European Psychiatry , Volume 65 , Special Issue S1: Abstracts of the 30th European Congress of Psychiatry , June 2022 , pp. S289
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of the European Psychiatric Association
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