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Relationship between internalizing and externalizing symptoms trajectories and perinatal risk factors in an epidemiological sample: Preliminary results from the remind project

Published online by Cambridge University Press:  13 August 2021

S. Grazioli ,
E. Rosi ,
F. Villa ,
M. Mauri ,
P. Brambilla ,
C. Bonivento ,
M. Molteni  and
M. Nobile
S. Grazioli*
Affiliation:
Developmental Psychopathology, Scientific Institute Eugenio Medea, Associazione La Nostra Famiglia, Bosisio Parini, Italy
E. Rosi
Affiliation:
Developmental Psychopathology, Scientific Institute Eugenio Medea, Associazione La Nostra Famiglia, Bosisio Parini, Italy
F. Villa
Affiliation:
Developmental Psychopathology, Scientific Institute Eugenio Medea, Associazione La Nostra Famiglia, Bosisio Parini, Italy
M. Mauri
Affiliation:
Developmental Psychopathology, Scientific Institute Eugenio Medea, Associazione La Nostra Famiglia, Bosisio Parini, Italy
P. Brambilla
Affiliation:
Department Of Pathophysiology And Transplantation, University of Milan, Milan, Italy
C. Bonivento
Affiliation:
Associazione La Nostra Famiglia, Scientific Institute, IRCCS E. Medea, Pasian di Prato, Italy
M. Molteni
Affiliation:
Developmental Psychopathology, Scientific Institute Eugenio Medea, Associazione La Nostra Famiglia, Bosisio Parini, Italy
M. Nobile
Affiliation:
Developmental Psychopathology, Scientific Institute Eugenio Medea, Associazione La Nostra Famiglia, Bosisio Parini, Italy
*
*Corresponding author.

Abstract

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Introduction

Our 15-years follow-up ReMIND project aims to re-assess an epidemiological and a clinical sample of adults (Wave 3), who were assessed in preadolescence (Wave 1) and adolescence (Wave 2), to evaluate symptoms trajectories and their relationship with genetic/epigenetic data, environmental risk factors and neuroimaging measures.

Objectives

Here, we depict preliminary results regarding the epidemiological sample.

Methods

We assessed internalizing and externalizing symptoms in 40 italian subjects (25 F) from general population at three waves (W1 mean age: 12±0,82; W2 mean age: 17±0,88, W3 mean age: 28±1), through the Child Behavior Checklist (W1 and W2) or the Adult Self Report (W3), and perinatal risk factors through a socio-anamnestic questionnaire, by a new online platform (MedicalBit). We analyzed symptoms trajectories and their relation with perinatal risk factors through a repeated measures multivariate analysis of variance (rm-MANOVA).

Results

rm-MANOVA results show that high number of perinatal risks was significantly associated with higher internalizing symptomatology in preadolescence but not in adolescence and adult life. The mean difference was 8 T-points. The same trend is evident in adolescence but not in adult age (Graph 1). Perinatal risk factors did not have a significant effect on externalizing symptoms at any time point, despite a non-significant trend is evident (Graph 2).

Conclusions

Our preliminary results suggest a trend of increased internalizing symptoms from childhood to adulthood and a significant role of perinatal risk factors in pre-adolescence. Further investigations are necessary to better understand symptoms trajectories and the role of biological and environmental factors.

Disclosure

No significant relationships.

Keywords

perinatal risk factorsinternalizing psychopathologyexternalizing psychopathologypsychopathology trajectories
Type
Abstract
Information
European Psychiatry , Volume 64 , Special Issue S1: Abstracts of the 29th European Congress of Psychiatry , April 2021 , pp. S148 - S149
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of the European Psychiatric Association
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