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Accepted manuscript

The role of cognitive reserve and clinical symptoms in the association between genetic liability for educational attainment and functioning in first-episode psychosis: a mediation analysis

Published online by Cambridge University Press:  05 January 2024

Derek Clougher Open the ORCID record for Derek Clougher [Opens in a new window] ,
Àlex G Segura Open the ORCID record for Àlex G Segura [Opens in a new window] ,
Maria Florencia Forte Open the ORCID record for Maria Florencia Forte [Opens in a new window] ,
Gisela Mezquida Open the ORCID record for Gisela Mezquida [Opens in a new window] ,
Manuel J Cuesta Open the ORCID record for Manuel J Cuesta [Opens in a new window] ,
Eduard Vieta Open the ORCID record for Eduard Vieta [Opens in a new window] ,
Silvia Amoretti Open the ORCID record for Silvia Amoretti [Opens in a new window] ,
Antonio Lobo Open the ORCID record for Antonio Lobo [Opens in a new window] ,
Ana González-Pinto  and
Covadonga M. Díaz-Caneja Open the ORCID record for Covadonga M. Díaz-Caneja [Opens in a new window]
...Show all authors
Derek Clougher
Affiliation:
Bipolar and Depressive Disorders Unit, Hospital Clinic of Barcelona, Institute of Neurosciences, IDIBAPS, University of Barcelona, Barcelona, Catalonia, Spain. Biomedical Research Networking Center for Mental Health Network (CIBERSAM), Barcelona, Spain.
Àlex G Segura
Affiliation:
Biomedical Research Networking Center for Mental Health Network (CIBERSAM), Barcelona, Spain. Department of Clinical Foundations, Pharmacology Unit, University of Barcelona, Barcelona, Spain.
Maria Florencia Forte
Affiliation:
Bipolar and Depressive Disorders Unit, Hospital Clinic of Barcelona, Institute of Neurosciences, IDIBAPS, University of Barcelona, Barcelona, Catalonia, Spain. Biomedical Research Networking Center for Mental Health Network (CIBERSAM), Barcelona, Spain. Barcelona Clinic Schizophrenia Unit, Hospital Clinic of Barcelona, Neuroscience Institute, University of Barcelona, August Pi I Sunyer Biomedical Research Institute (IDIBAPS), Spain.
Gisela Mezquida
Affiliation:
Biomedical Research Networking Center for Mental Health Network (CIBERSAM), Barcelona, Spain. Department of Clinical Foundations, Pharmacology Unit, University of Barcelona, Barcelona, Spain. Barcelona Clinic Schizophrenia Unit, Hospital Clinic of Barcelona, Neuroscience Institute, University of Barcelona, August Pi I Sunyer Biomedical Research Institute (IDIBAPS), Spain.
Manuel J Cuesta
Affiliation:
Department of Psychiatry, Complejo Hospitalario de Navarra, Pamplona, Spain. IdiSNA, Navarra Institute for Health Research, Pamplona, Spain.
Eduard Vieta*
Affiliation:
Bipolar and Depressive Disorders Unit, Hospital Clinic of Barcelona, Institute of Neurosciences, IDIBAPS, University of Barcelona, Barcelona, Catalonia, Spain. Biomedical Research Networking Center for Mental Health Network (CIBERSAM), Barcelona, Spain.
Silvia Amoretti*
Affiliation:
Bipolar and Depressive Disorders Unit, Hospital Clinic of Barcelona, Institute of Neurosciences, IDIBAPS, University of Barcelona, Barcelona, Catalonia, Spain. Biomedical Research Networking Center for Mental Health Network (CIBERSAM), Barcelona, Spain. Barcelona Clinic Schizophrenia Unit, Hospital Clinic of Barcelona, Neuroscience Institute, University of Barcelona, August Pi I Sunyer Biomedical Research Institute (IDIBAPS), Spain. Group of Psychiatry, Mental Health and Addictions, Vall d’Hebron Research Institute (VHIR), Psychiatric Genetics Unit, Vall d’Hebron Research Institute (VHIR), Barcelona, Catalonia, Spain.
Antonio Lobo
Affiliation:
Biomedical Research Networking Center for Mental Health Network (CIBERSAM), Barcelona, Spain. Department of Medicine and Psychiatry. Zaragoza University. Instituto de Investigación Sanitaria Aragón (IIS Aragón), Zaragoza, Spain.
Ana González-Pinto
Affiliation:
Biomedical Research Networking Center for Mental Health Network (CIBERSAM), Barcelona, Spain. Araba University Hospital, Bioaraba Research Institute, Spain. University of the Basque Country (UPV-EHU), Spain.
Covadonga M. Díaz-Caneja
Affiliation:
Biomedical Research Networking Center for Mental Health Network (CIBERSAM), Barcelona, Spain. Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, School of Medicine, Universidad Complutense, IiSGM, Madrid, Spain.
Alexandra Roldán
Affiliation:
Biomedical Research Networking Center for Mental Health Network (CIBERSAM), Barcelona, Spain. Department of Psychiatry, Institut d’Investigació Biomèdica-Sant Pau (IIB-SANT PAU), Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona (UAB), Barcelona, Spain.
Giovanna Fico
Affiliation:
Bipolar and Depressive Disorders Unit, Hospital Clinic of Barcelona, Institute of Neurosciences, IDIBAPS, University of Barcelona, Barcelona, Catalonia, Spain. Biomedical Research Networking Center for Mental Health Network (CIBERSAM), Barcelona, Spain.
Elena de la Serna
Affiliation:
Biomedical Research Networking Center for Mental Health Network (CIBERSAM), Barcelona, Spain. Department of Child and Adolescent Psychiatry and Psychology, 2017SGR881, Institut Clinic de Neurociències, Hospital Clínic Universitari, IDIBAPS, Department of Medicine, University of Barcelona, Barcelona, Spain.
Daniel Bergé
Affiliation:
Biomedical Research Networking Center for Mental Health Network (CIBERSAM), Barcelona, Spain. Hospital del Mar Medical Research Institute; Universitat Pompeu Fabra, MELIS Department, Barcelona, Spain.
Patricia Gassó
Affiliation:
Biomedical Research Networking Center for Mental Health Network (CIBERSAM), Barcelona, Spain. Department of Clinical Foundations, Pharmacology Unit, University of Barcelona, Barcelona, Spain.
Natalia Rodriguez
Affiliation:
Biomedical Research Networking Center for Mental Health Network (CIBERSAM), Barcelona, Spain. Department of Clinical Foundations, Pharmacology Unit, University of Barcelona, Barcelona, Spain.
Norma Verdolini
Affiliation:
Local Health Unit Umbria 1, Department of Mental Health, Mental Health Center of Perugia, Italy.
Alfonso Tortorella
Affiliation:
Section of Psychiatry, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.
Giulia Menculini
Affiliation:
Section of Psychiatry, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.
Marta Ribasés
Affiliation:
Biomedical Research Networking Center for Mental Health Network (CIBERSAM), Barcelona, Spain. Group of Psychiatry, Mental Health and Addictions, Vall d’Hebron Research Institute (VHIR), Psychiatric Genetics Unit, Vall d’Hebron Research Institute (VHIR), Barcelona, Catalonia, Spain.
Miguel Bernardo
Affiliation:
Biomedical Research Networking Center for Mental Health Network (CIBERSAM), Barcelona, Spain. Barcelona Clinic Schizophrenia Unit, Hospital Clinic of Barcelona, Neuroscience Institute, University of Barcelona, August Pi I Sunyer Biomedical Research Institute (IDIBAPS), Spain.
Sergi Mas
Affiliation:
Biomedical Research Networking Center for Mental Health Network (CIBERSAM), Barcelona, Spain. Department of Clinical Foundations, Pharmacology Unit, University of Barcelona, Barcelona, Spain.
*
*Corresponding authors: Eduard Vieta E-mail address: evieta@clinic.cat Silvia Amoretti E-mail address: silvia.amoretti@vhir.org Department of Psychiatry and Psychology. Clinical Institute of Neuroscience. Hospital Clinic of Barcelona, Villarroel, 170. 08036 Barcelona, Spain. Tel.: +34 93 227 54 00; fax: +34 93 227 92 28
*Corresponding authors: Eduard Vieta E-mail address: evieta@clinic.cat Silvia Amoretti E-mail address: silvia.amoretti@vhir.org Department of Psychiatry and Psychology. Clinical Institute of Neuroscience. Hospital Clinic of Barcelona, Villarroel, 170. 08036 Barcelona, Spain. Tel.: +34 93 227 54 00; fax: +34 93 227 92 28

Abstract

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Keywords

first-episode psychosispolygenic risk scorefunctioningcognitive reservenegative symptoms
Type
Research Article
Information
European Psychiatry , Accepted manuscript , pp. 1 - 31
Creative Commons
Creative Common License - CCCreative Common License - BYCreative Common License - NCCreative Common License - ND
This is an Open Access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is unaltered and is properly cited. The written permission of Cambridge University Press must be obtained for commercial re-use or in order to create a derivative work.
Copyright
© The Author(s), 2024. Published by Cambridge University Press on behalf of the European Psychiatric Association

Footnotes

¥

Derek Clougher and Àlex G Segura should be considered joint first author

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