Hostname: page-component-cd9895bd7-gxg78 Total loading time: 0 Render date: 2024-12-25T07:16:08.708Z Has data issue: false hasContentIssue false
  • English
  • Français

The role of high-density lipoprotein cholesterol in risk for posttraumatic stress disorder: Taking a nutritional approach toward universal prevention

Published online by Cambridge University Press:  15 April 2020

K. Hamazaki ,
D. Nishi ,
N. Yonemoto ,
H. Noguchi ,
Y. Kim  and
Y. Matsuoka
K. Hamazaki
Affiliation:
Department of Clinical Epidemiology, Translational Medical Center, National Center of Neurology and Psychiatry, Tokyo, Japan Department of Public Health, Faculty of Medicine, University of Toyama, Toyama, Japan CREST, Japan Science and Technology Agency, Tokyo, Japan
D. Nishi
Affiliation:
National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan Department of Psychiatry, National Disaster Medical Center, Tokyo, Japan CREST, Japan Science and Technology Agency, Tokyo, Japan
N. Yonemoto
Affiliation:
Department of Clinical Epidemiology, Translational Medical Center, National Center of Neurology and Psychiatry, Tokyo, Japan National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan CREST, Japan Science and Technology Agency, Tokyo, Japan
H. Noguchi
Affiliation:
Department of Clinical Epidemiology, Translational Medical Center, National Center of Neurology and Psychiatry, Tokyo, Japan CREST, Japan Science and Technology Agency, Tokyo, Japan
Y. Kim
Affiliation:
National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan
Y. Matsuoka*
Affiliation:
Department of Clinical Epidemiology, Translational Medical Center, National Center of Neurology and Psychiatry, Tokyo, Japan National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan Department of Psychiatry, National Disaster Medical Center, Tokyo, Japan CREST, Japan Science and Technology Agency, Tokyo, Japan
*
*Corresponding author at: Department of Clinical Epidemiology, Translational Medical Center, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi-cho, Kodaira, Tokyo 187-8551, Japan. E-mail address: yutaka@ncnp.go.jp (Y. Matsuoka).
Get access

Abstract

Several cross-sectional studies, but no prospective studies, have reported an association between an abnormal lipid profile and posttraumatic stress disorder (PTSD). We hypothesized that an abnormal lipid profile might predict risk for developing PTSD. In this prospective study, we analyzed data from 237 antidepressant-naïve severely injured patients who participated in the Tachikawa Cohort of Motor Vehicle Accident Study. High-density lipoprotein cholesterol (HDL-C) levels at baseline were significantly lower in patients with PTSD than those without PTSD at 6 months after motor vehicle accident (MVA) and were inversely associated with risk for PTSD. In contrast, triglycerides (TG) at baseline were significantly higher in patients with PTSD than in those without PTSD at 6 months post-MVA and were positively associated with risk for PTSD. There was no clear association between low-density lipoprotein cholesterol or total cholesterol and risk for PTSD. In conclusion, low HDL-C and high TG may be risk factors for PTSD. Determining lipid profiles might help identify those at risk for PTSD after experiencing trauma.

Keywords

Posttraumatic stress disorderEpidemiology ;Lipid profile
Type
Original article
Information
European Psychiatry , Volume 29 , Issue 7 , September 2014 , pp. 408 - 413
Copyright
Copyright © 2014 Elsevier Masson SAS

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Babic, D., Jakovljevic, M., Martinac, M., Saric, M., Topic, R., Maslov, B.Metabolic syndrome and combat posttraumatic stress disorder intensity: preliminary findings. Psychiatr Danub 2007;19:68–75.Google ScholarPubMed
Blake, D.D., Weathers, F.W., Nagy, L.M., Kaloupek, D.G., Gusman, F.D., Charney, D.S.et al.The development of a Clinician-Administered PTSD Scale. J Trauma Stress 1995;8:75–90.CrossRefGoogle ScholarPubMed
Buydens-Branchey, L., Branchey, M., Hudson, J., Fergeson, P., Low, H.D.L.cholesterol, aggression and altered central serotonergic activity. Psychiatry Res 2000;93:93–102.CrossRefGoogle ScholarPubMed
Carpentier, Y.A., Scruel, O.Changes in the concentration and composition of plasma lipoproteins during the acute phase response. Curr Opin Clin Nutr Metab Care 2002;5:153–158.CrossRefGoogle ScholarPubMed
Chandola, T., Brunner, E., Marmot, M.Chronic stress at work and the metabolic syndrome: prospective study. BMJ 2006;332:521–525.CrossRefGoogle ScholarPubMed
Crook, M., Haq, M., Tutt, P.Serum lipids, acute phase proteins and serum cholinesterase in normal subjects. Scand J Clin Lab Invest 1994;54:601–603.CrossRefGoogle ScholarPubMed
Davidson, J.R., Hughes, D., Blazer, D.G., George, L.K.Posttraumatic stress disorder in the community: an epidemiological study. Psychol Med 1991;21:713–721.CrossRefGoogle Scholar
Enders, C.K.A primer on the use of modern missing data methods in psychosomatic medicine research. Psychosom Med 2006;68:427–436.CrossRefGoogle ScholarPubMed
Fu, S.S., McFall, M., Saxon, A.J., Beckham, J.C., Carmody, T.P., Baker, D.G.et al.Posttraumatic stress disorder and smoking: a systematic review. Nicotine Tob Res 2007;9:1071–1084.CrossRefGoogle ScholarPubMed
Okamura, T., Hayakawa, T., Kadowaki, T., Kita, Y., Okayama, A., Ueshima, H.The inverse relationship between serum high-density lipoprotein cholesterol level and all-cause mortality in a 9.6-year follow-up study in the Japanese general population. Atherosclerosis 2006;184:143–150.CrossRefGoogle Scholar
Heppner, P.S., Crawford, E.F., Haji, U.A., Afari, N., Hauger, R.L., Dashevsky, B.A.et al.The association of posttraumatic stress disorder and metabolic syndrome: a study of increased health risk in veterans. BMC Med 2009;7:1.CrossRefGoogle ScholarPubMed
Spitzer, C., Barnow, S., Volzke, H., Wallaschofski, H., John, U., Freyberger, H.J.et al.Association of posttraumatic stress disorder with low-grade elevation of C-reactive protein: evidence from the general population. J Psychiatr Res 2010;44:15–21.CrossRefGoogle ScholarPubMed
Jakovljevic, M., Saric, M., Nad, S., Topic, R., Vuksan-Cusa, B.Metabolic syndrome, somatic and psychiatric comorbidity in war veterans with posttraumatic stress disorder: preliminary findings. Psychiatr Danub 2006;18:169–176.Google ScholarPubMed
Jin, H., Lanouette, N.M., Mudaliar, S., Henry, R., Folsom, D.P., Khandrika, S.et al.Association of posttraumatic stress disorder with increased prevalence of metabolic syndrome. J Clin Psychopharmacol 2009;29:210–215.CrossRefGoogle ScholarPubMed
Kagan, B.L., Leskin, G., Haas, B., Wilkins, J., Foy, D.Elevated lipid levels in Vietnam veterans with chronic posttraumatic stress disorder. Biol Psychiatry 1999;45:374–377.CrossRefGoogle ScholarPubMed
Karlovic, D., Buljan, D., Martinac, M., Marcinko, D.Serum lipid concentrations in Croatian veterans with posttraumatic stress disorder, posttraumatic stress disorder comorbid with major depressive disorder, or major depressive disorder. J Korean Med Sci 2004;19:431–436.CrossRefGoogle ScholarPubMed
Maia, D.B., Marmar, C.R., Mendlowicz, M.V., Metzler, T., Nobrega, A., Peres, M.C.et al.Abnormal serum lipid profile in Brazilian police officers with posttraumatic stress disorder. J Affect Disord 2008;107:259–263.CrossRefGoogle Scholar
Marmot, M.G., Bosma, H., Hemingway, H., Brunner, E., Stansfeld, S.Contribution of job control and other risk factors to social variations in coronary heart disease incidence. Lancet 1997;350:235–239.CrossRefGoogle ScholarPubMed
Martin, S.S., Blaha, M.J., Elshazly, M.B., Brinton, E.A., Toth, P.P., McEvoy, J.W.et al.Friedewald-estimated versus directly measured low-density lipoprotein cholesterol and treatment implications. J Am Coll Cardiol 2013;62:732–739.CrossRefGoogle ScholarPubMed
Matsuoka, Y., Nishi, D., Nakajima, S., Yonemoto, N., Hashimoto, K., Noguchi, H.et al.The Tachikawa cohort of motor vehicle accident study investigating psychological distress: design, methods and cohort profiles. Soc Psychiatry Psychiatr Epidemiol 2009;44:333–340.CrossRefGoogle ScholarPubMed
Matsuoka, Y., Nishi, D., Hamazaki, K.Serum levels of polyunsaturated fatty acids and the risk of posttraumatic stress disorder. Psychother Psychosom 2013;82:408–410.CrossRefGoogle ScholarPubMed
McEwen, B.S.Allostasis and allostatic load: implications for neuropsychopharmacology. Neuropsychopharmacology 2000;22:108–124.CrossRefGoogle ScholarPubMed
Morris, M.C., Rao, U.Psychobiology of PTSD in the acute aftermath of trauma: integrating research on coping, HPA function and sympathetic nervous system activity. Asian J Psychiatr 2013;6:3–21.CrossRefGoogle ScholarPubMed
Muldoon, M.F., Manuck, S.B., Matthews, K.A.Lowering cholesterol concentrations and mortality: a quantitative review of primary prevention trials. BMJ 1990;301:309–314.CrossRefGoogle ScholarPubMed
Muldoon, M.F., Mackey, R.H., Williams, K.V., Korytkowski, M.T., Flory, J.D., Manuck, S.B.Low central nervous system serotonergic responsivity is associated with the metabolic syndrome and physical inactivity. J Clin Endocrinol Metab 2004;89:266–271.CrossRefGoogle ScholarPubMed
Navab, M., Anantharamaiah, G.M., Reddy, S.T., Hama, S., Hough, G., Grijalva, V.R.et al.Oral D-4F causes formation of pre-beta high-density lipoprotein and improves high-density lipoprotein-mediated cholesterol efflux and reverse cholesterol transport from macrophages in apolipoprotein E-null mice. Circulation 2004;109:3215–3220.CrossRefGoogle ScholarPubMed
Nishi, D., Matsuoka, Y., Nakajima, S., Noguchi, H., Kim, Y., Kanba, S.et al.Are patients after severe injury who drop out of a longitudinal study at high risk of mental disorder?. Compr Psychiatry. 2008;49:393–398.CrossRefGoogle ScholarPubMed
Nishi, D., Noguchi, H., Yonemoto, N., Nakajima, S., Kim, Y., Matsuoka, Y.Incidence and prediction of posttraumatic stress disorder at 6 months after motor vehicle accidents in Japan. Psychosomatics 2013;54:263–271.CrossRefGoogle ScholarPubMed
Olszewski, T.M., Varrasse, J.F.The neurobiology of PTSD: implications for nurses. J Psychosoc Nurs Ment Health Serv 2005;43:40–47.Google ScholarPubMed
Teramoto, T., Sasaki, J., Ishibashi, S., Birou, S., Daida, H., Dohi, S.et al.Executive summary of the Japan Atherosclerosis Society (JAS) guidelines for the diagnosis and prevention of atherosclerotic cardiovascular diseases in Japan – 2012 version. J Atheroscler Thromb 2013;20:517–523.CrossRefGoogle ScholarPubMed
Tochigi, M., Umekage, T., Otani, T., Kato, T., Iwanami, A., Asukai, N.et al.Serum cholesterol, uric acid and cholinesterase in victims of the Tokyo subway sarin poisoning: a relation with posttraumatic stress disorder. Neurosci Res 2002;44:267–272.CrossRefGoogle Scholar
Violanti, J.M., Fekedulegn, D., Hartley, T.A., Andrew, M.E., Charles, L.E., Mnatsakanova, A.et al.Police trauma and cardiovascular disease: association between PTSD symptoms and metabolic syndrome. Int J Emerg Ment Health 2006;8:227–237.Google ScholarPubMed
Walker, E.A., Katon, W., Russo, J., Ciechanowski, P., Newman, E., Wagner, A.W.Health care costs associated with posttraumatic stress disorder symptoms in women. Arch Gen Psychiatry 2003;60:369–374.CrossRefGoogle ScholarPubMed
Yehuda, R.Current status of cortisol findings in posttraumatic stress disorder. Psychiatr Clin North Am 2002;25:341–368 [vii].CrossRefGoogle Scholar
Yehuda, R., Southwick, S.M., Nussbaum, G., Wahby, V., Giller, E.L. Jr., Mason, J.W.Low urinary cortisol excretion in patients with posttraumatic stress disorder. J Nerv Ment Dis 1990;178:366–369.CrossRefGoogle ScholarPubMed
Submit a response

Comments

No Comments have been published for this article.