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The Role of Neuroplasticity in the Treatment of Cognitive Impairments by Means Multifactor Neuro-Electrostimulation of the Segmental level of the Autonomic Nervous System

Published online by Cambridge University Press:  23 March 2020

T. Petrenko ,
V. Kublanov  and
K. Retyunskiy
T. Petrenko
Affiliation:
Ural Federal University, Research Medical and Biological Engineering Center of the High Technologies, Ekaterinburg, Russia
V. Kublanov
Affiliation:
Ural Federal University, Research Medical and Biological Engineering Center of the High Technologies, Ekaterinburg, Russia
K. Retyunskiy
Affiliation:
Ural State Medical University, Department of Psychiatry, Ekaterinburg, Russia

Abstract

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Introduction.

Cognitive deficit is a consequence of organic lesions of the central nervous system. Activation of neuroplasticity is a way of effective treatment. There is a suppose that the autonomic nervous system (ANS) involves in the regulation of neuroplasticity.

Objectives.

We developed a technology for non-invasive electrical stimulate segmental and suprasegmental parts of ANS [1].

Methods.

Developed technology is implemented in the “SYMPATHOCOR–01” device. The device produces spatially distributed field of current pulses between two multiple electrodes located on the neck. The targets of impact are cervical ganglia of the sympathetic trunk and vagus nerve.

Results.

The restoration of blood supply in artificial ischemia calf muscles and recovery of behavior patterns during acute phase of the adjustment disorder were received as a result of application technology in experiments on rats [2]. An increase global neurometabolic activity on SPECT was shown in clinical studies [2]. Application device for two weeks in children with ADHD led to reduction of inattention and hyperactivity symptoms [2].

Conclusion.

We suggest that the demonstrated clinical effects are the results of activate of neuroplasticity by impact on ANS structures. It is necessary to conduct fundamental studies by means of neurovisualization methods (fMRI, PET) for the confirmation action of these mechanisms.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Type
e-Poster Viewing: Psychosurgery and stimulation methods (ECT, TMS, VNS, DBS)
Information
European Psychiatry , Volume 41 , Issue S1: Abstract of the 25th European Congress of Psychiatry , April 2017 , pp. s770
Copyright
Copyright © European Psychiatric Association 2017

References

Kublanov, V.S.A hardware-software system for diagnosis and correction of autonomic dysfunctions. Biomed Eng 424:2008 206–21210.1007/s10527-008-9047-7CrossRefGoogle Scholar
Kublanov, V.S., et al.Multi-electrode neurostimulation system for treatment of cognitive impairments. Engineering in Medicine and Biology Society, 37th Annual International Conference of the IEEE 2015 2091–2094Google ScholarPubMed
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