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Tardive dyskinesias and antipsychotics: a review

Published online by Cambridge University Press:  16 April 2020

Pierre-Michel Llorca ,
Isabelle Chereau ,
Frank-Jean Bayle  and
Christophe Lancon
Pierre-Michel Llorca*
Affiliation:
C.M.P.B, C.H.U. Clermont-Ferrand, rue Montalembert, BP 69, 63003 Clermont-Ferrand cedex 1, France
Isabelle Chereau
Affiliation:
C.M.P.B, C.H.U. Clermont-Ferrand, rue Montalembert, BP 69, 63003 Clermont-Ferrand cedex 1, France
Frank-Jean Bayle
Affiliation:
Université Paris V, René Descartes et CH Sainte Anne, Service Hospitalo-Universitaire, 1, rue Cabanis, 75674 Paris cedex, France
Christophe Lancon
Affiliation:
Hôpital Sainte Marguerite, 270, boulevard Sainte Marguerite, 13009 Marseille, France
*
*Corresponding author. Tel.: +33-4-73-75-21-24; fax: +33-4-73-75-21-26. E-mail address: pmlfllorca@aol.com (P.M. Llorca).
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Summary

Currently, tardive dyskinesia (TD) remains an important clinical problem. The average prevalence is estimated at 30%. The appearance of antipsychotics has opened new paths. The extrapyramidal profile of these molecules is more favorable than that of conventional neuroleptics. In order to assess their prophylactic as well as curative potential, we reviewed the literature concerning four of these atypical antipsychotics: clozapine, risperidone olanzapine and amisulpride. Clozapine seems to induce fewer cases of TD than the conventional neuroleptics, and has a specific therapeutic effect. However, the risk of agranulocytosis reduces the possibility of utilisation. Risperidone appears to be an effective therapy, but several authors report cases of TD during treatment. Furthermore, larger studies and longer follow-ups are necessary to confirm the efficiency of olanzapine and amisulpride. Further studies and observations are still necessary before drawing any conclusion for these new atypical antipsychotic actions. They are doubtlessly promising, but we cannot ignore the notion of risk–benefit; regular monitoring and listening to the subjective experience of the patients must remain uppermost in the choice of therapy.

Keywords

Atypical antipsychoticsTardive dyskinesiasClozapineRisperidoneOlanzapineAmisulpride
Type
Review
Information
European Psychiatry , Volume 17 , Issue 3 , May 2002 , pp. 129 - 138
Copyright
Copyright © Éditions scientifiques et médicales Elsevier SAS. 2002

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