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Telomere attrition and inflammatory load in major depressive disorder

Published online by Cambridge University Press:  13 August 2021

A. Squassina
A. Squassina*
Affiliation:
Department Of Biomedical Sciences, University of Cagliari, Cagliari, Italy

Abstract

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Patients with major depressive disorder (MDD) present features that suggest the involvement of accelerated aging, such as increased circulating inflammatory markers and shorter telomere length (TL). Here we measured T-lymphocytes TL with quantitative fluorescent in situ hybridization (Q-FISH) and plasma levels of inflammatory markers in a cohort of 37 patients with MDD and 36 non-psychiatric controls (C). TL was shorter in MDD compared to C (F=8.52, p=0.005). Patients with treatment resistant (TR) MDD showed higher levels of TNFα compared to non-TR (adjusted p= 0.034) and C (adjusted p=0.025), suggesting that treatment resistance might be associated with increased inflammation compared to non-TR.

Disclosure

No significant relationships.

Keywords

aginginflammationtelomere lengthmood disorders
Type
Abstract
Information
European Psychiatry , Volume 64 , Special Issue S1: Abstracts of the 29th European Congress of Psychiatry , April 2021 , pp. S11 - S12
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of the European Psychiatric Association
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