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The thalamus and its subregions – a gateway to obsessive-compulsive disorder

Published online by Cambridge University Press:  01 September 2022

C. Weeland ,
C. Vriend ,
Y. Van Der Werf ,
C. Huyser ,
M. Hillegers ,
H. Tiemeier ,
T. White ,
N. De Joode ,
P. Thompson  and
D. Stein
...Show all authors
C. Weeland*
Affiliation:
Amsterdam UMC, Department Of Anatomy And Neurosciences; Department Of Psychiatry, Amsterdam, Netherlands
C. Vriend
Affiliation:
Amsterdam UMC, Department Of Anatomy And Neurosciences; Department Of Psychiatry, Amsterdam, Netherlands
Y. Van Der Werf
Affiliation:
Amsterdam UMC, Department Of Anatomy And Neurosciences; Department Of Psychiatry, Amsterdam, Netherlands
C. Huyser
Affiliation:
Academic Center for Child and Adolescent Psychiatry, De Bascule, Amsterdam, Netherlands
M. Hillegers
Affiliation:
Erasmus Medical Center, Department Of Child And Adolescent Psychiatry, Rotterdam, Netherlands
H. Tiemeier
Affiliation:
Harvard TH Chan School of Public Health, -, Boston, United States of America
T. White
Affiliation:
Erasmus MC, Child And Adolescent Psychiatry And Psychology, Rotterdam, Netherlands
N. De Joode
Affiliation:
Amsterdam UMC, Department Of Anatomy And Neurosciences; Department Of Psychiatry, Amsterdam, Netherlands
P. Thompson
Affiliation:
eImaging Genetics Center, Stevens Institute for Neuroimaging & Informatics, Keck School of Medicine, University of Southern California, -, Los Angeles, United States of America
D. Stein
Affiliation:
University of Cape Town, Dept Of Psychiatry & Neuroscience Institute, Cape Town, South Africa
O. Van Den Heuvel
Affiliation:
Amsterdam UMC, Department Of Anatomy And Neurosciences; Department Of Psychiatry, Amsterdam, Netherlands
S. Kasprzak
Affiliation:
Amsterdam UMC, Department Of Anatomy And Neurosciences; Department Of Psychiatry, Amsterdam, Netherlands
*
*Corresponding author.

Abstract

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Introduction

Higher thalamic volume has been found in children with obsessive-compulsive disorder (OCD) and children with clinical-level symptoms within the general population (Boedhoe et al. 2017, Weeland et al. 2021a). Functionally distinct thalamic nuclei are an integral part of OCD-relevant brain circuitry.

Objectives

We aimed to study the thalamic nuclei volume in relation to subclinical and clinical OCD across different age ranges. Understanding the role of thalamic nuclei and their associated circuits in pediatric OCD could lead towards treatment strategies specifically targeting these circuits.

Methods

We studied the relationship between thalamic nuclei and obsessive-compulsive symptoms (OCS) in a large sample of school-aged children from the Generation R Study (N = 2500) (Weeland et al. 2021b). Using the data from the ENIGMA-OCD working group we conducted mega-analyses to study thalamic subregional volume in OCD across the lifespan in 2,649 OCD patients and 2,774 healthy controls across 29 sites (Weeland et al. 2021c). Thalamic nuclei were grouped into five subregions: anterior, ventral, intralaminar/medial, lateral and pulvinar (Figure 1).

Results

Both children with subclinical and clinical OCD compared with controls show increased volume across multiple thalamic subregions. Adult OCD patients have decreased volume across all subregions (Figure 2), which was mostly driven by medicated and adult-onset patients.

Conclusions

Our results suggests that OCD-related thalamic volume differences are global and not driven by particular subregions and that the direction of effects are driven by both age and medication status.

Disclosure

No significant relationships.

Keywords

OCDthalamusNeuroimagingsegmentation
Type
Abstract
Information
European Psychiatry , Volume 65 , Special Issue S1: Abstracts of the 30th European Congress of Psychiatry , June 2022 , pp. S77 - S78
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of the European Psychiatric Association
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