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The thyrotropin-releasing hormone test: some statistical considerations

Published online by Cambridge University Press:  16 April 2020

CA de Mendonca Lima ,
S Vandel  and
P Bizouard
CA de Mendonca Lima
Affiliation:
Service Psycho-Social, 18, rue de l'Hôtel de Ville, 1920Martigny, Switzerland
S Vandel
Affiliation:
Centre Hospitalier Universitaire de Besançon, 25000Besançon, France
P Bizouard
Affiliation:
Centre Hospitalier Universitaire de Besançon, 25000Besançon, France
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Summary

Final conclusions and data comparisons from the thyrotropin-releasing hormone (TRH) test results are made difficult by differences in test implementation methods, ie, TRH different administration routes, dosages and blood sampling times. A number of statistical analyses are feasible, which may also influence test interpretation. The authors review some types of statistical analyses and suggest using the area under curve (AUC) method as a means of evaluation. The TRH test was performed before treatment and after a 5-day wash-out period, in 40 depressed patients hospitalized in the Psychiatric Unit of Besancon Teaching Hospital (Centre Hospitalier Universitaire de Besançon). Variation analyses performed by peak and threshold comparison (7.0 IµU/ml) and by the AUC method (386 IµU/ml) in positive and negative patients revealed some statistical differences.

Keywords

depressionTRH test
Type
Short communication
Information
European Psychiatry , Volume 7 , Issue 1 , 1992 , pp. 39 - 42
Copyright
Copyright © Elsevier, Paris 1992

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