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Timing is critical: Gene, environment and timing interactions in genetics of suicide in children and adolescents

Published online by Cambridge University Press:  16 April 2020

G. Zalsman
G. Zalsman*
Affiliation:
Child and Adolescent Psychiatry Division, Geha Mental Health Center, PO Box 102, 49100Petach Tiqwa, Israel Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel Molecular Imaging and Neuropathology Devision, Psychitry Department, Columbia University, New York, USA
*
*Tel.: +972 3 9258 205; fax: +972 3 924 1041. E-mail address: zalsman@post.tau.ac.il
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Abstract

Suicidal behavior runs in families and is prevalent in adolescence. Case-control and family-based studies in this age group failed to find a genetic association that survived replications. Gene environment approach gave new hope for possible associations especially with the short allele of the serotonin transporter promoter polymorphism (5-HTTLPR). However, a recent meta-analysis raised doubts about the consistency of these findings. Some new structural and functional imaging data may shade light on the age-related and gender-related development of the brain. This review suggests a new approach to gene by environment and timing interaction to understand the interplay that leads to suicidality in adolescents and young adults.

Keywords

SuicideAdolescentsTimingGene environment interactionImagingPolymorphism
Type
Review
Information
European Psychiatry , Volume 25 , Issue 5: The role of genetics in promoting suicide prevention and the mental health of the population - Nobel Conference: The role of genetics in promoting suicide prevention and the mental health of the population , June 2010 , pp. 284 - 286
Copyright
Copyright © Elsevier Masson SAS 2010

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Footnotes

Invited paper. Presented at the Nobel Forum, Stockholm, Sweden, June, 10th, 2009.

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