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Trimodal approach (PET/MR/EEG) of response inhibition as a possible biomarker for schizophrenia

Published online by Cambridge University Press:  23 March 2020

C. Wyss ,
K. Heekeren ,
A. Del Guerra ,
N.J. Shah ,
I. Neuner  and
K. Wolfram
C. Wyss*
Affiliation:
University Hospital of Psychiatry Zurich, Department for Psychiatry, Psychotherapy and Psychosomatics, Zurich, Switzerland
K. Heekeren
Affiliation:
University Hospital of Psychiatry Zurich, Department for Psychiatry, Psychotherapy and Psychosomatics, Zurich, Switzerland
A. Del Guerra
Affiliation:
University of Pisa, Department of Physics “E. Fermi”, Pisa, Italy
N.J. Shah
Affiliation:
Research Centre Jülich, Institute of Neuroscience and Medicine- INM-4, Jülich, Germany
I. Neuner
Affiliation:
Research Centre Jülich, Institute of Neuroscience and Medicine- INM-4, Jülich, Germany RWTH Aachen University, Department of Psychiatry, Psychotherapy and Psychosomatics, Aachen, Germany
K. Wolfram
Affiliation:
University Hospital of Psychiatry Zurich, Department for Psychiatry, Psychotherapy and Psychosomatics, Zurich, Switzerland
*
*Corresponding author.

Abstract

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Introduction

The aim of the FP7-European funded project TRIMAGE is to create a trimodal, cost-effective imaging tool consisting of PET/MR/EEG to enable effective early diagnosis of schizophrenia.

Objective

In the scope of this project we are interested in the multimodal assessment of response inhibition. The loudness dependence of auditory evoked potential (LDAEP) is a suitable biomarker of inhibitory action in signal processing. Variations in response inhibition can have great impact on different aspects of life. Individuals with reduced capability of inhibitory control have a tendency to impulsive behavior. Studies showed that they have stronger LDAEP values. Patients with schizophrenia may exhibit alterations in the responsiveness to sensory stimuli. Thus, a reduced LDAEP was found in these patients. However, these deviances differed in clinical features of the disorder. Therefore, we would like to further elucidate the relationship between multimodal neuroimaging methods and dimensions of symptoms, observable behavior, personality traits and general psychopathological dysfunction.

Methods

A sample of 20 healthy controls and 20 patients with manifest schizophrenia will be examined with the LDAEP paradigm in a trimodal approach with customary imaging tools. PET measurements with the radiotracer [11C]-flumazenil will be used to assess the binding potentials of GABA-A receptors. MRS will provide data about GABA concentrations. Simultaneously recorded EEG-fMRI data will permit new insight in the relationship between LDAEP and impulsivity.

Discussion

The project will use alternative approaches to psychiatric classification. Response inhibition in sensory processing will be investigated from different angles (biochemical, neurophysiological, and neuroanatomical) and combined with psychological characteristic values.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Type
FC46
Information
European Psychiatry , Volume 33 , Issue S1: Abstracts of the 24th European Congress of Psychiatry , March 2016 , pp. S88 - S89
Copyright
Copyright © European Psychiatric Association 2016
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