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Triple network in adolescents with borderline personality disorder, early traumatic experiences and dissociative symptoms: An eloreta study

Published online by Cambridge University Press:  13 August 2021

C. Di Maggio ,
C. Massullo ,
C. Imperatori ,
O. Palazzolo ,
B. Farina ,
M. Brinciotti ,
M. Ferrara ,
V. Guidetti  and
A. Terrinoni
C. Di Maggio*
Affiliation:
Department Of Human Neuroscience, Section Of Child And Adolescent Neuropsychiatry, Phd Program In Behavioral Neuroscience, Sapienza University of Rome, RM, Italy
C. Massullo
Affiliation:
Department Of Human Science, Cognitive And Clinical Psychology Lab, European University of Rome, Rome, Italy
C. Imperatori
Affiliation:
Department Of Human Science, Cognitive And Clinical Psychology Lab, European University of Rome, Rome, Italy
O. Palazzolo
Affiliation:
Department Of Human Science, Cognitive And Clinical Psychology Lab, European University of Rome, Rome, Italy
B. Farina
Affiliation:
Department Of Human Science, Cognitive And Clinical Psychology Lab, European University of Rome, Rome, Italy
M. Brinciotti
Affiliation:
Department Of Human Neuroscience, Section Of Child And Adolescent Neuropsychiatry, Sapienza University of Rome, Rome, Italy
M. Ferrara
Affiliation:
Department Of Human Neuroscience, Section Of Child And Adolescent Neuropsychiatry, Sapienza University of Rome, Rome, Italy
V. Guidetti
Affiliation:
Department Of Human Neuroscience, Section Of Child And Adolescent Neuropsychiatry, Phd Program In Behavioral Neuroscience, Sapienza University of Rome, RM, Italy
A. Terrinoni
Affiliation:
Department Of Human Neuroscience, Section Of Child And Adolescent Neuropsychiatry, Sapienza University of Rome, Rome, Italy
*
*Corresponding author.

Abstract

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Introduction

Triple Network Model (TNM), which considers the dynamic interaction between Default Mode (DMN), Salience (SN), and Central Executive (CEN) networks, explains clinical features in mental disorders from a neurophysiological perspective. Some studies highlight the increased connectivity in TNM in adults with Borderline Personality Disorder (BPD), but little is known about adolescents.

Objectives

The aim of our preliminary study was to investigate TN functional connectivity (FC) in BPD adolescents with a history of traumatic experiences, and its correlation with dissociative symptoms.

Methods

15 BPD adolescents (DSM-5 criteria) with early traumatic experiences were compared to 15 healthy controls, matched for sex and age. Dissociation Questionnaire (DIS-Q) was administered. Eyes-closed resting-state (RS) EEG recordings were performed (19 electrodes; 10- 20 system) and analyzed using Exact Low-Resolution Electromagnetic Tomography software (eLORETA). FC was computed for all frequency bands and 9 Regions of Interest for TNM.

Results

BPD adolescents showed a hyper-connection between CEN and DMN [dorso-lateral prefrontal cortex (dlPFC) and posterior cingulate cortex (PCC); PCC and left posterior parietal cortex (PPC)] and within the CEN (left and right PPC). The strength of PCC-dlPFC and left-right PPC connections was correlated with dissociative symptoms severity.

Conclusions

FC alterations can already be identified in BPD adolescents, supporting the need for early diagnosis. Normally DMN and CEN show opposite functioning. In our BPD adolescents, the absence of this “anti-correlation” reflects the typical confusion between internal and external mental states, which clarify their difficulties in metacognition or mentalization. Moreover, in dissociative symptoms, two CEN nodes are also involved, not only DMN as previously described.

Disclosure

No significant relationships.

Keywords

Borderline personality disordertriple networkadolescentseeg functional connectivity
Type
Abstract
Information
European Psychiatry , Volume 64 , Special Issue S1: Abstracts of the 29th European Congress of Psychiatry , April 2021 , pp. S140
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of the European Psychiatric Association
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