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Recent advances in gene therapy with skin cells

Published online by Cambridge University Press:  23 July 2002

MARCELA DEL RIO ,
FERNANDO LARCHER  and
JOSÉ LUIS JORCANO
MARCELA DEL RIO
Affiliation:
Project of Cell and Molecular Biology and Gene Therapy, CIEMAT, Avenida Complutense 22, 28040 Madrid, Spain and Fundacion Marcelino Botín for Gene Therapy. E-mail: jl.jorcano@ciemat.es
FERNANDO LARCHER
Affiliation:
Project of Cell and Molecular Biology and Gene Therapy, CIEMAT, Avenida Complutense 22, 28040 Madrid, Spain and Fundacion Marcelino Botín for Gene Therapy. E-mail: jl.jorcano@ciemat.es
JOSÉ LUIS JORCANO
Affiliation:
Project of Cell and Molecular Biology and Gene Therapy, CIEMAT, Avenida Complutense 22, 28040 Madrid, Spain and Fundacion Marcelino Botín for Gene Therapy. E-mail: jl.jorcano@ciemat.es
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Abstract

Somatic gene therapy remains a promising therapeutic approach for both inherited and acquired disorders. Among the tissues amenable to gene therapy, the skin, and particularly the epidermal cells, present several features advantageous for genetic manipulation and monitoring of therapeutic effects. Candidate diseases for cutaneous gene therapy not only involve skin defects but also systemic abnormalities. The robust basic and pre-clinical data gathered during the last few years have allowed the imminent launching of keratinocyte-based gene therapy with applications to patients.

Type
Research Article
Information
European Review , Volume 10 , Issue 3 , July 2002 , pp. 369 - 388
Copyright
© Academia Europaea 2002

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