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Arbovirus lifecycle in mosquito: acquisition, propagation and transmission

Published online by Cambridge University Press:  13 March 2019

Pa Wu ,
Xi Yu ,
Penghua Wang  and
Gong Cheng Open the ORCID record for Gong Cheng [Opens in a new window]
Pa Wu
Affiliation:
Tsinghua-Peking Center for Life Sciences, School of Medicine, Tsinghua University, Beijing, 100084, China SZCDC-SUSTech Joint Key Laboratory for Tropical Diseases, Shenzhen Center for Disease Control and Prevention, Shenzhen, Guangdong, 518055, China
Xi Yu
Affiliation:
Tsinghua-Peking Center for Life Sciences, School of Medicine, Tsinghua University, Beijing, 100084, China SZCDC-SUSTech Joint Key Laboratory for Tropical Diseases, Shenzhen Center for Disease Control and Prevention, Shenzhen, Guangdong, 518055, China
Penghua Wang
Affiliation:
Department of Immunology, School of Medicine, the University of Connecticut Health Center, Farmington, CT, 06030, USA
Gong Cheng*
Affiliation:
Tsinghua-Peking Center for Life Sciences, School of Medicine, Tsinghua University, Beijing, 100084, China SZCDC-SUSTech Joint Key Laboratory for Tropical Diseases, Shenzhen Center for Disease Control and Prevention, Shenzhen, Guangdong, 518055, China
*
Author for correspondence: Gong Cheng, E-mail: gongcheng@mail.tsinghua.edu.cn
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Abstract

Mosquitoes are haematophagous vectors for hundreds of pathogenic viruses that are aetiological agents of human diseases. In nature, mosquito-borne viruses maintain a lifecycle between mosquitoes and vertebrate animals. Viruses are acquired by a naive mosquito from an infected host by blood meals and then propagate extensively in the mosquito's tissues. This mosquito then becomes a virus reservoir and is competent to transmit the viruses to a naive vertebrate host through the next blood meal. To survive in and efficiently cycle between two distinct host environments, mosquito-borne viruses have evolved delicate and smart strategies to comprehensively exploit host and vector factors. Here, we provide an update on recent studies of the mechanisms of virus survival in, acquisition and transmission by mosquitoes.

Keywords

Arbovirusesmosquitoestransmission
Type
Invited Review
Information
Expert Reviews in Molecular Medicine , Volume 21 , 2019 , e1
Copyright
Copyright © Cambridge University Press 2019 

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