Mechanisms in allergic airway inflammation – lessons from studies in the mouse

Bennett O.V. Shum; Michael S. Rolph; William A. Sewell

doi:10.1017/S1462399408000707

Mechanisms in allergic airway inflammation – lessons from studies in the mouse

Published online by Cambridge University Press: 27 May 2008

Bennett O.V. Shum ,

Michael S. Rolph and

William A. Sewell

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Bennett O.V. Shum: Affiliation:
Immunology and Inflammation Research Program, Garvan Institute for Medical Research, Darlinghurst, New South Wales, Australia. CRC for Asthma and Airways, Camperdown, New South Wales, Australia.
Michael S. Rolph: Affiliation:
Immunology and Inflammation Research Program, Garvan Institute for Medical Research, Darlinghurst, New South Wales, Australia. CRC for Asthma and Airways, Camperdown, New South Wales, Australia.
William A. Sewell*: Affiliation:
Immunology and Inflammation Research Program, Garvan Institute for Medical Research, Darlinghurst, New South Wales, Australia. St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Sydney, Australia.
*: *Corresponding author: William Sewell, Immunology and Inflammation Research Program, Garvan Institute for Medical Research, 384 Victoria St, Darlinghurst, New South Wales 2010, Australia. Tel: +61 2 9295 8434; Fax: +61 2 9295 8404; E-mail: w.sewell@garvan.org.au

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Abstract

Asthma is a chronic inflammatory disease of the airways, involving recurrent episodes of airway obstruction and wheezing. A common pathological feature in asthma is the presence of a characteristic allergic airway inflammatory response involving extensive leukocyte infiltration, mucus overproduction and airway hyper-reactivity. The pathogenesis of allergic airway inflammation is complex, involving multiple cell types such as T helper 2 cells, regulatory T cells, eosinophils, dendritic cells, mast cells, and parenchymal cells of the lung. The cellular response in allergic airway inflammation is controlled by a broad range of bioactive mediators, including IgE, cytokines and chemokines. The asthmatic allergic inflammatory response has been a particular focus of efforts to develop novel therapeutic agents. Animal models are widely used to investigate inflammatory mechanisms. Although these models are not perfect replicas of clinical asthma, such studies have led to the development of numerous novel therapeutic agents, of which some have already been successful in clinical trials.

Type: Review Article
Information: Expert Reviews in Molecular Medicine , Volume 10 , October 2008 , e15

DOI: https://doi.org/10.1017/S1462399408000707 [Opens in a new window]
Copyright: Copyright © Cambridge University Press 2008

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Mechanisms in allergic airway inflammation – lessons from studies in the mouse

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Mechanisms in allergic airway inflammation – lessons from studies in the mouse

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