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Herpetic eye disease: immunopathogenesis and therapeutic measures

Published online by Cambridge University Press:  30 March 2004

Shilpa Deshpande ,
Kaustuv Banerjee ,
Partha Sarathi Biswas  and
Barry T. Rouse
Shilpa Deshpande
Affiliation:
Department of Microbiology, M 409, Walters Life Sciences Bldg, 1414 Cumberland Avenue, College of Arts and Sciences, University of Tennessee, Knoxville, TN 37996, USA.
Kaustuv Banerjee
Affiliation:
Comparative and Experimental Medicine, M 409, Walters Life Sciences Bldg, 1414 Cumberland Avenue, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA.
Partha Sarathi Biswas
Affiliation:
Comparative and Experimental Medicine, M 409, Walters Life Sciences Bldg, 1414 Cumberland Avenue, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA.
Barry T. Rouse
Affiliation:
Department of Microbiology, M 409, Walters Life Sciences Bldg, 1414 Cumberland Avenue, College of Arts and Sciences, University of Tennessee, Knoxville, TN 37996, USA.
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Abstract

Infection of the cornea with herpes simplex virus (HSV) can result in a chronic disease called herpetic stromal keratitis (HSK). The disease represents one of the leading causes of infectious blindness in the Western world. Immune-mediated cellular damage is suspected in the pathogenesis of human HSK. The murine model has been pivotal in further establishing HSK as an immunopathological disease. This article reviews understanding of HSK, both in humans and in the mouse model, with an emphasis on possible future therapeutic strategies to counteract this blinding immunoinflammatory disease

Keywords

Herpetic stromal keratitisimmunopathologychemokinescytokinesT lymphocytespolymorphonuclear leucocytesangiogenesiseyeinflammation
Type
Review Article
Information
Expert Reviews in Molecular Medicine , Volume 6 , Issue 8 , 30 March 2004 , pp. 1 - 14
Copyright
© Cambridge University Press 2004

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