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Implications of reproductive technologies for birth and developmental outcomes: imprinting defects and beyond

Published online by Cambridge University Press:  05 June 2006

Ariane Paoloni-Giacobino
Ariane Paoloni-Giacobino
Affiliation:
Department of Molecular Genetics and Biochemistry, University of Pittsburgh Medical School, 200 Lothrop Street, Pittsburgh, PA 15213, USA.
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Abstract

Assisted reproductive techniques (ARTs) have been widely used over the past two decades to help infertile couples conceive. Recent studies on the ART-conceived population have raised concern about the possible risks of these techniques, in particular with regard to increased incidence of growth and developmental disorders. Some of these effects might be linked to genomic imprinting defects, although current evidence does not allow definite conclusions to be drawn. This review summarises studies that have examined effects of gamete and embryo manipulations on imprinted genes, and discusses the evidence for and against effects of ARTs on offspring health, and in particular imprinting-related conditions.

Keywords

Assisted reproductionimprintingepigeneticdevelopmentinfertilityfetal growth
Type
Review Article
Information
Expert Reviews in Molecular Medicine , Volume 8 , Issue 12 , 5 June 2006 , pp. 1 - 14
Copyright
© Cambridge University Press 2006

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