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Molecular medicine of gastric adenocarcinomas

Published online by Cambridge University Press:  30 August 2005

Gisela Keller ,
Heinz Höfler  and
Karl-Friedrich Becker
Gisela Keller
Affiliation:
Institute of Pathology, Technical University of Munich, Trogerstr. 18, 81675 München, Germany.
Heinz Höfler
Affiliation:
Institute of Pathology, Technical University of Munich, Trogerstr. 18, 81675 München, Germany.
Karl-Friedrich Becker
Affiliation:
Institute of Pathology, Technical University of Munich, Trogerstr. 18, 81675 München, Germany.
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Abstract

Upper gastrointestinal (GI) tract malignancies, including carcinomas of the esophagus, the GI junction and the stomach, are among the most common cancers worldwide. Overall survival is poor because many patients present with locally advanced and often incurable disease. This review focuses on the pathogenesis of adenocarcinomas of the stomach. It summarises recent findings on genetic predisposition to gastric cancer, in particular in relation to germline mutations in the E-cadherin gene. It also describes the molecular basis of sporadic gastric cancer, including alterations in oncogenes, tumour suppressor genes and growth factors, and discusses how these findings might be used in the clinic for improved diagnosis and therapy.

Keywords

E-cadherinp53gastric cancerfamilial gastric cancertumour suppressor genesoncogenescell adhesiontherapygenetic predisposition
Type
Review Article
Information
Expert Reviews in Molecular Medicine , Volume 7 , Issue 17 , 30 August 2005 , pp. 1 - 13
Copyright
© Cambridge University Press 2005

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