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Novel roles and therapeutic targets of Epstein–Barr virus-encoded latent membrane protein 1-induced oncogenesis in nasopharyngeal carcinoma

Published online by Cambridge University Press:  18 August 2015

Yongguang Tao ,
Ying Shi ,
Jiantao Jia ,
Yiqun Jiang ,
Lifang Yang  and
Ya Cao
Yongguang Tao*
Affiliation:
Cancer Research Institute, Central South University, Changsha, Hunan 410078, China Center for Molecular Imaging, Central South University, Changsha, Changsha, Hunan 410078, China Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Changsha, Hunan 410078, China Key Laboratory of Carcinogenesis, Ministry of Health, Changsha, Hunan 410078, China Collaborative Innovation Center of Molecular Engineering for Theranostics, Changsha, Changsha, Hunan 410078, China
Ying Shi
Affiliation:
Cancer Research Institute, Central South University, Changsha, Hunan 410078, China Center for Molecular Imaging, Central South University, Changsha, Changsha, Hunan 410078, China Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Changsha, Hunan 410078, China Key Laboratory of Carcinogenesis, Ministry of Health, Changsha, Hunan 410078, China
Jiantao Jia
Affiliation:
Cancer Research Institute, Central South University, Changsha, Hunan 410078, China Center for Molecular Imaging, Central South University, Changsha, Changsha, Hunan 410078, China Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Changsha, Hunan 410078, China Key Laboratory of Carcinogenesis, Ministry of Health, Changsha, Hunan 410078, China
Yiqun Jiang
Affiliation:
Cancer Research Institute, Central South University, Changsha, Hunan 410078, China Center for Molecular Imaging, Central South University, Changsha, Changsha, Hunan 410078, China Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Changsha, Hunan 410078, China Key Laboratory of Carcinogenesis, Ministry of Health, Changsha, Hunan 410078, China
Lifang Yang
Affiliation:
Cancer Research Institute, Central South University, Changsha, Hunan 410078, China Center for Molecular Imaging, Central South University, Changsha, Changsha, Hunan 410078, China Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Changsha, Hunan 410078, China Key Laboratory of Carcinogenesis, Ministry of Health, Changsha, Hunan 410078, China Collaborative Innovation Center of Molecular Engineering for Theranostics, Changsha, Changsha, Hunan 410078, China
Ya Cao*
Affiliation:
Cancer Research Institute, Central South University, Changsha, Hunan 410078, China Center for Molecular Imaging, Central South University, Changsha, Changsha, Hunan 410078, China Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Changsha, Hunan 410078, China Key Laboratory of Carcinogenesis, Ministry of Health, Changsha, Hunan 410078, China Collaborative Innovation Center of Molecular Engineering for Theranostics, Changsha, Changsha, Hunan 410078, China
*
*Corresponding authors: Y. Tao, Cancer Research Institute, Central South University, Changsha, Hunan, 410078China. Tel. +(86) 731-84805448; Fax. +(86) 731-84470589 Email: taoyong@csu.edu.cnY. Cao, Cancer Research Institute, Central South University, Changsha, Hunan 410078, China Email: ycao98@vip.sina.com
*Corresponding authors: Y. Tao, Cancer Research Institute, Central South University, Changsha, Hunan, 410078China. Tel. +(86) 731-84805448; Fax. +(86) 731-84470589 Email: taoyong@csu.edu.cnY. Cao, Cancer Research Institute, Central South University, Changsha, Hunan 410078, China Email: ycao98@vip.sina.com
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Abstract

Epstein–Barr virus (EBV) was first discovered 50 years ago as an oncogenic gamma-1 herpesvirus and infects more than 90% of the worldwide adult population. Nasopharyngeal carcinoma (NPC) poses a serious health problem in southern China and is one of the most common cancers among the Chinese. There is now strong evidence supporting a role for EBV in the pathogenesis of NPC. Latent membrane protein 1 (LMP1), a primary oncoprotein encoded by EBV, alters several functional and oncogenic properties, including transformation, cell death and survival in epithelial cells in NPC. LMP1 may increase protein modification, such as phosphorylation, and initiate aberrant signalling via derailed activation of host adaptor molecules and transcription factors. Here, we summarise the novel features of different domains of LMP1 and several new LMP1-mediated signalling pathways in NPC. When then focus on the potential roles of LMP1 in cancer stem cells, metabolism reprogramming, epigenetic modifications and therapy strategies in NPC.

Type
Review Article
Information
Expert Reviews in Molecular Medicine , Volume 17 , 2015 , e15
Copyright
Copyright © Cambridge University Press 2015 

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